Skip to main content

Advertisement

SpringerLink
Log in

Gastric metastasis from esophageal squamous cell carcinoma producing granulocyte colony-stimulating factor: report of a case and literature review

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

We report an extremely rare case of gastric metastasis from a granulocyte colony-stimulating factor (G-CSF)-producing carcinoma of the esophagus. A 63-year-old Japanese man presented with an aggressive esophageal and gastric tumor and concomitant severe leukocytosis (21,700/mm3) with pyrexia. The serum level of G-CSF was markedly elevated to 253 pg/ml (normal < 9.8 pg/ml). Histological examination of the surgical specimen showed a moderately differentiated squamous cell carcinoma (SCC) of the esophagus and stomach, with tumor cells immunohistochemically positive for G-CSF. The leukocyte count and G-CSF concentration decreased after surgery. The patient was diagnosed with G-CSF-producing esophageal SCC with gastric metastasis. This is the first case of G-CSF-producing esophageal SCC with gastric metastasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Watanabe HA, Matsushita H, Matsui H et al (1999) Esophageal carcinoma with high serum parathyroid hormone-related protein (PTHrP) level. J Gastroenterol 34:510–515

    Article  CAS  PubMed  Google Scholar 

  2. Matsumoto G, Ise H, Kimura Y et al (2000) Granulocyte-colony stimulating factor producing esophageal carcinoma :serum level as a marker for monitoring the effects of treatment. Int J Clin Oncol 5:328–333

    Article  Google Scholar 

  3. Ichiishi E, Yoshikawa T, Kogawa T et al (2000) Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus. Gut 46:432–434

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Kato M, Osawa H, Usui N et al (2002) An autopsy case of esophageal squamous cell carcinoma associated with granulocyte-colony stimulating factor production. Jikei Med J 49:191–195

    Google Scholar 

  5. Komatsu D, Sakurai M, Nakafuji H et al (2003) Granulocyte colony stimulating factor-producing collision tumor of the gastric cardia. J Gastroenterol 38:1013–1018

    Article  PubMed  Google Scholar 

  6. Nakata K, Ohtsuka T, Sato S et al (2006) Esophageal carcinoma with humoral hypercalcemia and leukocytosis successfully treated by a two-stage operation: report of a case. Esophagus 3:13–17

    Article  Google Scholar 

  7. Mimatsu K, Takatsugu O, Kano H et al (2008) Aggressive progression of granulocyte colony-stimulating factor producing squamous cell carcinoma of the esophagus: case report and literature review. Esophagus 5:205–209

    Article  Google Scholar 

  8. Tanabe T, Kanda T, Ishihara N et al (2009) An esophageal squamous cell carcinoma patient with high serum granulocyte-colony stimulating factor level: report of a case. Esophagus 6:253–258

    Article  Google Scholar 

  9. Mayanagi S, Niihara M, Goto H et al (2013) Granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma following chemoradiotherapy and bone marrow transplantation for acute lymphoblastic leukemia. Esophagus 10:258–263

    Article  PubMed Central  PubMed  Google Scholar 

  10. Asano S, Urabe A, Okabe T et al (1977) Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood 49:845–852

    CAS  PubMed  Google Scholar 

  11. Ebihara Y, Hosokawa M, Kondo S et al (2004) Thirteen cases with intramural metastasis to the stomach in 1259 patients with oesophageal squamous cell carcinoma. Eur J Cardiothorac Surg 26:1223–1225

    Article  PubMed  Google Scholar 

  12. Takubo K, Sasajima K, Yamashita K et al (1990) Prognostic significance of intramural metastasis in patients with esophageal carcinoma. Cancer 65:1816–1819

    Article  CAS  PubMed  Google Scholar 

  13. Uehara M, Manaka D, Matsutani Y et al (2008) Gastric wall metastasis from esophageal carcinoma: report of a case. Jpn J Gastroenterol Surg 41:41–45

    Article  Google Scholar 

  14. Watoson WL (1993) Carcinoma at the esophagus. Surg Gynecol Obstet 56:884–897

    Google Scholar 

  15. Berdel WE, Danhauser-Riedl S, Steinhauser G et al (1989) Various human hematopoietic growth factors (interleukin-3, GMCSF, G-CSF) stimulate clonal growth of nonhematopoietic tumor cells. Blood 73:80–83

    CAS  PubMed  Google Scholar 

  16. Tachibana M, Miyakawa A, Tazaki H et al (1995) Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor. Cancer Res 55:3438–3443

    CAS  PubMed  Google Scholar 

  17. Natsugoe S, Matsushita Y, Chuman Y et al (1999) So-called carcinosarcoma of the esophagus: a clinicopathologic, immunohistochemical and DNA flow-cytometric analysis of 6 cases. Oncology 57:29–35

    Article  CAS  PubMed  Google Scholar 

  18. Natori T, Sata M, Washida M et al (2002) G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells. Biochem Biophys Res Commun 297:1058–1061

    Article  CAS  PubMed  Google Scholar 

  19. Shojaei F, Wu X, Qu X et al (2009) G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci USA 106:6742–6747

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Schlahsa L, Jaimes Y, Blasczyk R et al (2011) Granulocyte-colonary-stimulatory factor: a strong inhibitor of natural killer function. Transfusion 51:293–305

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

All authors certify that they have no conflicts of interest with any financial organization. No funding support was received for this study.

Author information

Authors and Affiliations

  1. Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Graduate School of Medicine, Tokyo, 113-8603, Japan

    Nobutoshi Hagiwara, Takeshi Matsutani, Tsutomu Nomura, Eriko Shinozuka & Eiji Uchida

  2. Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173-0015, Japan

    Junko Aida & Kaiyo Takubo

Authors
  1. Nobutoshi Hagiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeshi Matsutani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tsutomu Nomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eriko Shinozuka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Junko Aida
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kaiyo Takubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Eiji Uchida
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nobutoshi Hagiwara.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hagiwara, N., Matsutani, T., Nomura, T. et al. Gastric metastasis from esophageal squamous cell carcinoma producing granulocyte colony-stimulating factor: report of a case and literature review. Int Canc Conf J 4, 229–235 (2015). https://doi.org/10.1007/s13691-015-0207-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-015-0207-9

Keywords

Search

Navigation