Abstract
Intracranial hypotension (IH) is noted to be a cause of postural headache. Progress in diagnostic imaging modalities, such as magnetic resonance imaging (MRI) had contributed to the diagnosis for IH (Thomke et al., Nervenarzt 70:909–915, 1999), revealing the presences of IH in various situations. A 48-year-old female with left breast cancer underwent the breast conserving surgery in April 2003, and mastectomy for ipsilateral breast cancer in December 2007. Multiple lung metastases were found in both lungs over the next year. After receiving an EC regimen for five cycles, the patient’s lung metastases were improved. Subsequently, she received docetaxel according to a weekly regimen. Following the administration of docetaxel for 10 months, the patient suffered from dyspnea, headache, vertigo, and diplopia, and was diagnosed with IH based on the MRI findings. Her symptoms improved with bed rest, hydration and the administration of dexamethasone. In this case, the patient developed IH under conditions of severe fluid retention as a side effect of docetaxel. We herein report this rare case of IH related to cancer therapy.
This is a preview of subscription content, log in via an institution to check access.
References
Thomke F, Bredel-Geissler A, Mika-Gruttner A et al (1999) Spontaneous intracranial hypotension syndrome. Clinical, neuroradiological and cerebrospinal fluid findings. Nervenarzt 70:909–915
Case records of the Massachusetts General Hospital (1998) Weekly clinicopathological exercises. Case 2-1998. A 50-year-old woman with increasing headache and a left abducent-nerve palsy. N Engl J Med 338:180–188
Moayeri NN, Henson JW, Schaefer PW, Zervas NT (1998) Spinal dural enhancement on magnetic resonance imaging associated with spontaneous intracranial hypotension. Report of three cases and review of the literature. J Neurosurg 88:912–918
Baker J, Ajani J, Scotte F et al (2008) Docetaxel-related side effects and their management. Eur J Oncol Nurs 12:253–268
Schrijvers D, Wanders J, Dirix L et al (1993) Coping with toxicities of docetaxel (Taxotere). Ann Oncol 4:610–611
Pronk LC, Stoter G, Verweij J (1995) Docetaxel (Taxotere): Single agent activity, development of combination treatment and reducing side-effects. Cancer Treat Rev 21:463–478
Vincenzi B, Santini D, Frezza AM et al (2007) Docetaxel induced pericardial effusion. J Exp Clin Cancer Res 26:417–420
Mailliez A, Baldini C, Van JT et al (2010) Nasal septum perforation: a side effect of bevacizumab chemotherapy in breast cancer patients. Br J Cancer 103:772–775
Cosar-Alas R, Alas A, Ozen A et al (2010) Capecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: case report and review of the literature. J Cancer Res Ther 6:557–559
Fishman RA, Dillon WP (1993) Dural enhancement and cerebral displacement secondary to intracranial hypotension. Neurology 43:609–611
Yousry I, Forderreuther S, Moriggl B et al (2001) Cervical MR imaging in postural headache: MR signs and pathophysiological implications. AJNR Am J Neuroradiol 22:1239–1250
Inamasu J, Nakamura Y, Orii M et al (2004) Treatment of spontaneous intracranial hypotension secondary to C-2 meningeal cyst by surgical packing-case report. Neurol Med Chir (Tokyo) 44:326–330
Conflict of Interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Nakagomi, H., Furuya, K., Nakayama, Y. et al. A case of intracranial hypotension caused by docetaxel treatment for metastatic breast cancer. Int Canc Conf J 4, 184–187 (2015). https://doi.org/10.1007/s13691-014-0196-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13691-014-0196-0