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Effectiveness of pazopanib for postoperative recurrence of granulocyte colony-stimulating factor-producing primary hepatic angiosarcoma

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Abstract

A 38-year-old Japanese woman was referred to our hospital with complaints of fever, general fatigue, and upper abdominal discomfort. Computed tomography revealed a massive tumor in the right lobe of the liver, and laboratory data demonstrated increased white blood cell (WBC) count and serum granulocyte colony-stimulating factor (G-CSF) level. An extended right hepatectomy was performed, and pathological examination revealed spindle-shape tumor cells that formed vessel-like structures that were compatible with hepatic angiosarcoma. As a rapid recurrence occurred after surgery, S-1 was administered as a first-line chemotherapy, and weekly paclitaxel was administered as the second-line chemotherapy. However, patient eventually became resistant to these therapies. Therefore, pazopanib, a multitargeted tyrosine kinase inhibitor, was administered, after which both the WBC count and G-CSF level rapidly decreased. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) revealed decreased FDG uptake. This is the first report on the administration of pazopanib as a third-line chemotherapeutic agent for treating G-CSF-producing primary hepatic angiosarcoma. The efficacy of this therapy was demonstrated with FDG-PET.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Clinical Gastroenterology and Hepatology on Co-operative Network, Asahikawa Medical University, 2-1 Midorigaoka Higashi, Asahikawa, 078-8510, Japan

    Koji Sawada & Takaaki Ohtake

  2. Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan

    Manabu Soma, Shunsuke Nakajima, Takumu Hasebe, Shigeaki Maeda, Masami Abe, Takaaki Ohtake, Mikihiro Fujiya & Yutaka Kohgo

  3. Department of Gastroenterology, Asahikawa-Kosei General Hospital, Asahikawa, Japan

    Yoshinori Saito

  4. Department of Gastroenterology, Asahikawa Red Cross Hospital, Asahikawa, Japan

    Chitomi Hasebe

  5. Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Japan

    Masahiro Yamamoto

  6. Oncology Center, Asahikawa Medical University Hospital, Asahikawa, Japan

    Yoshihiro Torimoto

Authors
  1. Koji Sawada
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  2. Manabu Soma
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  3. Shunsuke Nakajima
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  4. Takumu Hasebe
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  5. Shigeaki Maeda
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  6. Masami Abe
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  7. Takaaki Ohtake
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  8. Yoshinori Saito
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  9. Chitomi Hasebe
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  10. Masahiro Yamamoto
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  11. Mikihiro Fujiya
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  12. Yoshihiro Torimoto
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  13. Yutaka Kohgo
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Corresponding author

Correspondence to Koji Sawada.

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Sawada, K., Soma, M., Nakajima, S. et al. Effectiveness of pazopanib for postoperative recurrence of granulocyte colony-stimulating factor-producing primary hepatic angiosarcoma. Int Canc Conf J 4, 41–47 (2015). https://doi.org/10.1007/s13691-014-0167-5

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  • DOI: https://doi.org/10.1007/s13691-014-0167-5

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