Skip to main content

Advertisement

SpringerLink
Log in

Sarcoidosis or sarcoid-like reaction developed during the follow-up of malignant tumors: difficulties in differentiation from recurrent or metastatic diseases

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

Sarcoidosis or sarcoid-like reaction can occur or manifest several years after completion of treatment during the long-term follow-up of malignant tumors, often creating difficulty in differentiating these lesions from recurrent or metastatic malignant tumors on imaging studies. In recent years, CT and positron-emission tomography (PET) have been widely used in follow-up of malignant tumors; and findings in these studies are similar for sarcoidosis/sarcoid-like reaction and recurrent/metastatic diseases, special caution is needed in diagnosing either of these disorders. In patients who show results incompatible with recurrent or metastatic disease clinically and in imaging studies, even if increased FDG uptake on PET images is noted, biopsy should be performed, thereby allowing unnecessary treatments to be avoided.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

References

  1. Diagnostic Standard and Guideline for Sarcoidosis—2006 (2007) JJSOG 27:95–102

    Google Scholar 

  2. Cohen PR, Kurzrock R (2007) Sarcoidosis and malignancy. Clin Dematol 25:326–333

    Article  Google Scholar 

  3. Brincker H (1986) Sarcoid reactions in malignant tumors. Cancer Treat Rev 3:147–156

    Article  Google Scholar 

  4. Hunsaker AR, Munden RF, Pugatch RD et al (1996) Sarcoidlike reaction in patients with malignancy. Radiology 200:255–261

    Article  PubMed  CAS  Google Scholar 

  5. Hunt BM, Vallieres E, Buduhan G et al (2009) Sarcoidosis as a benign cause of lymphadenopathy in cancer patients. Am J Surg 197:629–632

    Article  PubMed  Google Scholar 

  6. Chowdhury FU, Sheerin F, Bradley KM et al (2009) Sacoid-like reaction to malignancy on wholebody integrated 18F-FDG PET/CT:prevalence and disease pattern. Clin Radiol 64:675–681

    Article  PubMed  CAS  Google Scholar 

  7. Maeda A, Ohta M, Hirabayashi H et al (2005) False positive accumulation in 18F fluorodeoxyglucose positron emission tomography scan due to sarcoid reaction following induction chemotherapy for lung cancer. Jpn J Thorac Cardiovasc Surg 53:196–198

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Radiology, Kinki University-Faculty of Medicine, Nara Hospital, 1248-1 Otodo-Cho, Ikoma, Nara, Japan

    Kazuhisa Fujiwara, Hirokazu Hasegawa, Tatsuyuki Nishikawa & Kaoru Okajima

  2. Medical Chart, 4-3-11 Saigoutohri, Moriguchi, Osaka, Japan

    Kazuhisa Fujiwara

Authors
  1. Kazuhisa Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hirokazu Hasegawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tatsuyuki Nishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kaoru Okajima
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kazuhisa Fujiwara.

About this article

Cite this article

Fujiwara, K., Hasegawa, H., Nishikawa, T. et al. Sarcoidosis or sarcoid-like reaction developed during the follow-up of malignant tumors: difficulties in differentiation from recurrent or metastatic diseases. Int Canc Conf J 3, 220–226 (2014). https://doi.org/10.1007/s13691-014-0151-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-014-0151-0

Keywords

Search

Navigation