Skip to main content

Advertisement

SpringerLink
Log in

Recurrence Patterns and Management Options in Aggressive Fibromatosis

  • Original Article
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

Aggressive fibromatosis is a rare neoplasm arising from musculoaponeurotic structures. Our aim is to share our experience with this rare tumor in our institute and to discuss the more perplexing recurrence patterns and the management options. This is a retrospective study of the disease, treated in our institute for the past fourteen years. A total of 36 patients were analyzed. The demographic pattern of the disease, various treatment modalities offered and their outcome along with patterns of recurrence were studied. Our study showed a demographic pattern mostly similar to the rest of the world. But the pattern of recurrence and the multicentric and the non-random pattern of presentation observed in our study showed some difference from the other studies. We suggest surgery as the primary modality with radiation reserved for select patients with margin positivity, inoperable tumors, and multiple tumors. Since the disease has a long natural history a wait and watch policy can be observed for giving adjuvant RT. There is need for prospective multi-institutional RCTs to shed light on the unknown facts about this disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Alman BA, Pajerski ME, Diaz-Cano S, Corboy K, Wolfe HJ (1997) Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder. Diagn Mol Pathol 6:98–101

    Article  PubMed  CAS  Google Scholar 

  2. Wara WM, Phillips TL, Hill DR et al (1977) Desmoid tumors—treatment and prognosis. Radiology 124:225–226

    PubMed  CAS  Google Scholar 

  3. Li M, Cordon-Cardo C, Gerald WL, Rosai J (1996) Desmoid fibromatosis is a clonal process. Hum Pathol 27:939–943

    Article  PubMed  CAS  Google Scholar 

  4. Merchant NP, Lewis JJ, Leung DH, Woodruff JM, Brennan MF (2012) Extremity and trunk desmoid tumors: a multifactorial analysis of outcome. Cancer

  5. Wold LE, Weiland LH (1983) Tumefactive fibro-inflammatory lesions of the head and neck. Am J Surg Pathol 7:477–482

    Article  PubMed  CAS  Google Scholar 

  6. Posner MC, Shiu MH, Newsome JL, Hajdu SI, Gaynor JJ, Brennan MF (1989) The desmoid tumor: not a benign disease. Arch Surg 124:191–196

    Article  PubMed  CAS  Google Scholar 

  7. Goy BW, Lee SP, Fu YS, Selch MT, Eilber F (1998) Treatment results of unresected or partially resected desmoid tumors. Am J Clin Oncol 21(6):584–590

    Article  PubMed  CAS  Google Scholar 

  8. Spear MA, Jennings LC, Mankin HJ, Spiro IJ, Springfield DS, Gebhardt MC, Rosenberg AE, Efird JT, Suit HD (1998) management of aggressive fibromatoses. Int J Radiat Oncol Biol Phys 40(3):637–645

    Article  PubMed  CAS  Google Scholar 

  9. Suit HD, Spiro IJ, Spear M (1997) Benign and low-grade tumors of the soft tissues: role for radiation therapy. Cancer Treat Res 91:95–105

    Article  PubMed  CAS  Google Scholar 

  10. Abeloff M, ArmiTAGE. J, Niederhuber. J Abeloff’s Clinical Oncology, 4th edition, May-2008

  11. Fong Y, Rosen PP, Brennan MF (1993) Multifocal desmoids. Surgery 114:902–906

    PubMed  CAS  Google Scholar 

  12. Easter DW, Halasz NA (1989) Recent trends in the management of desmoids tumors. Summary of 19 cases and review of the literature. Ann Surg 210:765–769

    Article  PubMed  CAS  Google Scholar 

  13. Leibel SA, Wara WM, Hill DR et al (1983) Desmoid tumors: local control and patterns of relapse following radiation therapy. Int J Radiat Oncol Biol Phys 9:1167–1171

    Article  PubMed  CAS  Google Scholar 

  14. Sherman NE, Romsdahl M, Evans H, Zagars G, Oswald MJ (1990) Desmoid tumors: a 20-year radiotherapy experience. Int J Radiat Oncol Biol Phys 19:37–40

    Article  PubMed  CAS  Google Scholar 

  15. Kinzbrunner B, Ritter S, Domingo J, Rosenthal CJ (1983) Remission of rapidly growing desmoid tumors after tamoxifen therapy. Cancer 52:2201–2204

    Article  PubMed  CAS  Google Scholar 

  16. Waddell WR, Gerner RE, Reich MP (1983) Nonsteroid anti-inflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach. J Surg Oncol 22:197–211

    Article  PubMed  CAS  Google Scholar 

  17. Wilcken N, Tattersall MH (1991) Endocrine therapy for desmoid tumors. Cancer 68:1384–1388

    Article  PubMed  CAS  Google Scholar 

  18. Gronchi A, Casali PG, Mariani L (2003) Quality of surgery and outcome in extra-abdominal aggressive Fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol 21(7):1390–1397

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical oncology, Govt. Royapettah hospital, Kilpauk medical college, Chennai, Tamil Nadu, 600014, India

    Rajaraman Ramamurthy, Balasubramanian Arumugam & Balasubramaniam Ramanandham

  2. “RAMA SWATHI”, 11/25, 7th main road, Raja Annamalaipuram, Chennai, 600028, Tamil Nadu, India

    Rajaraman Ramamurthy

Authors
  1. Rajaraman Ramamurthy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Balasubramanian Arumugam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Balasubramaniam Ramanandham
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rajaraman Ramamurthy.

Additional information

Synopsis: We suggest surgery as the primary modality with radiation reserved for select patients

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ramamurthy, R., Arumugam, B. & Ramanandham, B. Recurrence Patterns and Management Options in Aggressive Fibromatosis. Indian J Surg Oncol 3, 222–227 (2012). https://doi.org/10.1007/s13193-012-0146-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-012-0146-2

Keywords

Search

Navigation