Skip to main content

Advertisement

Log in

Malignant lymphoma of the breast in a male patient: ultrasound imaging features

  • Case Report
  • Published:
Breast Cancer Aims and scope Submit manuscript

Abstract

Non-Hodgkin lymphoma (NHL) of the breast is a rare disease. Herein, we report a rare case of secondary involvement of the breast by NHL in a male patient and the ultrasound imaging findings. A 70-year-old man noticed an induration of the subareolar region of the right breast. He had been diagnosed as having mantle cell lymphoma 5 years before and treated with several series of chemoradiotherapy. On supine examination, palpation revealed bilateral breast enlargement, but detection of a lump was difficult. Ultrasonography showed a hypoechoic non-mass image-forming lesion in the subareolar region of the right breast. The final pathological diagnosis was recurrence of mantle cell lymphoma in the right breast. The diagnosis of malignant lymphoma of the breast by imaging modalities is difficult because there are no specific features. Breast lymphoma should be included with gynecomastia and breast cancer in the differential diagnosis of male patients with breast enlargement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Darnell A, Gallard X, Sentis M, Castaner E, Fernandez E, Villajos M. Primary lymphoma of the breast: MR imaging features. A case report. Magn Reson Imaging. 1999;17:479–82.

    Article  CAS  PubMed  Google Scholar 

  2. Murata T, Kuroda H, Nakahama T, Goshima H, Shiraishi T, Yatani R. Primary non-Hodgkin malignant lymphoma of the male breast. Jpn J Clin Oncol. 1996;26:243–7.

    Article  CAS  PubMed  Google Scholar 

  3. Lamovec J, Jancar J. Primary malignant lymphoma of the breast: lymphoma of mucosa-associated lymphoid tissue. Cancer. 1987;60:3033–41.

    Article  CAS  PubMed  Google Scholar 

  4. Mattia AR, Ferry JA, Harris NL. Breast lymphoma: a B-cell spectrum including the low grade B-cell lymphoma of mucosa associated lymphoid tissue. Am J Surg Pathol. 1993;17:574–87.

    Article  CAS  PubMed  Google Scholar 

  5. Liberman L, Giess CS, Dershaw DD, Louie DC, Deutch BM. Non-Hodgkin lymphoma of the breast: imaging characteristics and correlation with histopathologic findings. Radiology. 1994;192:157–60.

    Article  CAS  PubMed  Google Scholar 

  6. Mpallas G, Simatos G, Tasidou A, Patra E, Galateros G, Lakiotis G, et al. Primary breast lymphoma in a male patient. Breast. 2004;13:436–8.

    Article  CAS  PubMed  Google Scholar 

  7. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumors of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC; 2008.

    Google Scholar 

  8. Mori K, Inoue Y, Nishi T, Fukuuchi A, Ibukuro K, Tsukiyama T. Primary malignant lymphoma of the breast: mammographic and ultrasonographic findings. Breast Cancer. 1998;5:93–7.

    Article  PubMed  Google Scholar 

  9. Pope TL Jr, Brenbridge AN, Sloop FB Jr, Morris JR 3rd, Carpenter J. Primary histiocytic lymphoma of the breast: mammographic, sonographic, and pathologic correlation. J Clin Ultrasound. 1985;13:667–70.

    PubMed  Google Scholar 

  10. Sashiyama H, Abe Y, Miyazawa Y, Nagashima T, Hasegawa M, Okuyama K, et al. Primary non-Hodgkin’s lymphoma of the male breast: a case report. Breast Cancer. 1999;6:55–8.

    Article  PubMed  Google Scholar 

  11. Arber DA, Simpson JF, Weiss LM, Rappaport H. Non-Hodgkin’s lymphoma involving the breast. Am J Surg Pathol. 1994;18:288–95.

    Article  CAS  PubMed  Google Scholar 

  12. Mattia AR, Ferry JA, Harris NL. Breast lymphoma. A B-cell spectrum including the low grade B-cell lymphoma of mucosa associated lymphoid tissue. Am J Surg Pathol. 1993;17:574–87.

    Article  CAS  PubMed  Google Scholar 

  13. Jeon HJ, Akagi T, Hoshida Y, Hayashi K, Yoshino T, Tanaka T, et al. Primary non-Hodgkin malignant lymphoma of the breast. An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. Cancer. 1992;70:2451–9.

    Article  CAS  PubMed  Google Scholar 

  14. Hinoshita E, Tashiro H, Takahashi II, Onohara T, Nishizaki T, Matsusaka T, et al. Primary non-Hodgkin’s lymphoma of the breast: a report of two cases. Breast Cancer. 1998;5:309–12.

    Article  PubMed  Google Scholar 

  15. Uesato M, Miyazawa Y, Gunji Y, Ochiai T. Primary non-Hodgkin’s lymphoma of the breast: report of a case with special reference to 380 cases in the Japanese literature. Breast Cancer. 2005;12:154–8.

    Article  PubMed  Google Scholar 

  16. Wong WW, Schild SE, Halyard MY, Schomberg PJ. Primary non-Hodgkin lymphoma of the breast: the Mayo Clinic experience. J Surg Oncol. 2002;80:19–25; discussion 26.

    Google Scholar 

  17. Duman BB, Sahin B, Guvenc B, Ergin M. Lymphoma of the breast in a male patient. Med Oncol. 2010;28(Suppl 1):S490–3.

    Google Scholar 

  18. Janes SE, Lengyel JA, Singh S, Aluwihare N, Isgar B. Needle core biopsy for the assessment of unilateral breast masses in men. Breast. 2006;15:273–5.

    Article  PubMed  Google Scholar 

  19. Miura Y, Nishizawa M, Kaneko H, Watanabe M, Tsudo M. A male with primary breast lymphoma. Am J Hematol. 2009;84:191–2.

    Article  PubMed  Google Scholar 

  20. Abbondanzo SL, Seidman JD, Lefkowitz M, Tavassoli FA, Krinshnan J. Primary diffuse large B-cell lymphoma of the breast. A clinicopathologic study of 31 cases. Pathol Res Pract. 1996;192:37–43.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tatsuhiko Ikeda.

About this article

Cite this article

Ikeda, T., Bando, H., Iguchi, A. et al. Malignant lymphoma of the breast in a male patient: ultrasound imaging features. Breast Cancer 22, 201–205 (2015). https://doi.org/10.1007/s12282-012-0349-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12282-012-0349-y

Keywords

Navigation