Abstract
The present study describes a series of primary soft tissue lymphomas, including immunohistochemical characterization by tissue microarray and cytogenetic profiling. Formalin-fixed, paraffin-embedded tissue samples were collected from patients who underwent soft tissue biopsy. Cases were selected according to the definition of primary soft tissue lymphoma as a lymphoid malignancy arising in soft tissues without evidence of other nodal or extranodal localization for a period of at least 6 months. Our series comprised seven patients with a mean age of 72 years. There were three diffuse large B-cell lymphomas (DLBCLs); one B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma; one DLBCL derived from follicular lymphoma; one ALK-negative anaplastic large cell lymphoma; and one follicular lymphoma. Immunohistochemical and molecular profiles were consistent with the histological diagnoses. The present study contributes to our knowledge about uncommon presentation of lymphoid neoplasms and confirms previously published clinical-pathological data. We present, for the first time, the complete immunohistochemical profile and molecular cytogenetic studies of these lymphoid neoplasms. A rare case of a primary soft tissue ALK-negative anaplastic large cell lymphoma is described in detail.
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Derenzini E, Casadei B, Pellegrini C, Argnani L, Pileri S, Zinzani PL (2013) Non-hodgkin lymphomas presenting as soft tissue masses: a single center experience and meta-analysis of the published series. Clin Lymphoma Myeloma Leuk 13:258–265
Kransdorf MJ (1995) Is it necessary to routinely use gadolinium in the MR imaging evaluation of soft-tissue tumors of the extremities? AJR Am J Roentgenol 165:1545
Yang J, Zhang F, Fang H, et al. (2010) Clinicopathologic features of primary lymphoma in soft tissue. Leuk Lymphoma 51:2039–2046
Travis WD, Banks PM, Reiman HM (1987) Primary extranodal soft tissue lymphoma of the extremities. Am J Surg Pathol 11:359–366
Salamao DR, Nascimento AG, Lloyd RV, et al. (1996) Lymphoma in soft tissue: a clinicopathologic study of 19 cases. Hum Pathol 27:253–257
O’Neill JK, Devaraj V, Silver DA, et al. (2007) Extranodal lymphomas presenting as soft tissue sarcomas to a sarcoma service over a two-year period. J Plast Reconstr Aesthet Surg 60:646–654
Damron TA, Le MH, Rooney MT, et al. (1999) Lymphoma presenting as a soft tissue mass. A soft tissue sarcoma simulator. Clin Orthop Relat Res 360:221–230
Hudacko R, Rapkiewicz A, Berman RS, et al. (2011) ALK-negative anaplastic large cell lymphoma mimicking a soft tissue sarcoma. J Cytol 28:230–233
Knowles B, Serpell JW (2003) Extra-nodal lymphoma presenting as a mimic of soft-tissue sarcoma. ANZ J Surg 73:26–30
Suresh S, Saifuddin A, O’Donnell P (2008) Lymphoma presenting as a musculoskeletal soft tissue mass: MRI findings in 24 cases. Eur Radiol 18:2628–2634
Chun CW, Jee WH, Park HJ, et al. (2010) MRI features of skeletal muscle lymphoma. AJR Am J Roentgenol 195:1355–1360
Hans CP, Weisenburger DD, Greiner TC, et al. (2004) Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 103:275–282
Lanham GR, Weiss SW, Enzinger FM (1989) Malignant lymphoma. A study of 75 cases presenting in soft tissue. Am J Surg Pathol 13:1–10
Chun CW, Jee WH, Park HJ, Kim YJ, Park JM, Lee SH, Park SH (2010) MRI features of skeletal muscle lymphoma. AJR Am J Roentgenol 195:1355–1360
Carroll G, Breidahl W, Robbins P (2013) Musculoskeletal lymphoma: MRI of bone or soft tissue presentations. J Med Imaging Radiat Oncol 57:663–673
Pant V, Jambhekar NA, Madur B, Shet TM, Agarwal M, Puri A, Gujral S, Banavali M, Arora B (2007) Anaplastic large cell lymphoma (ALCL) presenting as primary bone and soft tissue sarcoma--a study of 12 cases. Indian J Pathol Microbiol 50:303–307
Driss M, Abbes I, Mrad K, Sassi S, Oubich F, Barsaoui S, Romdhane KB (2009) Primary CD30/ALK-1 positive anaplastic large cell lymphoma of the skeletal muscle in a child. Pathologica 101:97–100
Ishii E, Honda K, Nakagawa A, et al. (2000) Primary CD30/ki-1 positive anaplastic large cell lymphoma of skeletal muscle with der; 17t(1;17)(q11;p11). Cancer Genet Cytogenet 122:116–120
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Del Gobbo, A., Fiori, S., Ercoli, G. et al. Primary Soft Tissue Lymphomas: Description of Seven Cases and Review of the Literature. Pathol. Oncol. Res. 23, 281–286 (2017). https://doi.org/10.1007/s12253-016-0096-z
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DOI: https://doi.org/10.1007/s12253-016-0096-z