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Genetic epidemiology of coronary artery disease: an Asian Indian perspective

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Abstract

Coronary artery disease (CAD) has emerged as a major cause of morbidity and mortality worldwide. Recent findings on the role of genetic factors in the aetiopathology of CAD have implicated novel genes and variants in addition to those involved in lipid and lipoprotein metabolism. However, our present knowledge is limited due to lack of clarity on their exact identity and the quantum of impact on disease susceptibility, and incident risk. It is a matter of great interest to understand the role of genetic factors in ethnic populations that have a strong underlying predisposition to CAD such as the South Asian populations, particularly among Asian Indians living in India and abroad. Although, a number of isolated studies do implicate certain gene polymorphisms towards enhanced disease susceptibility, the available data remains scanty and inconclusive as they have not been validated in large, prospective cohorts. The present review aims to consolidate the available literature on the genetics of CAD in Asian Indians and seeks to provide insights on the concerns that need to be addressed in future studies to generate information having clinical value.

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References

  • Abate N., Chandalia M., Satija P., Adams-Huet B., Grundy S. M., Sandeep S. et al. 2005 ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes 54, 1207–1213.

  • Agrawal S., Singh V. P., Tewari S., Sinha N., Ramesh V., Agarwal S. et al. 2004 Angiotensin-converting enzyme gene polymorphism in coronary artery disease in north India. Indian Heart J. 56, 44–46.

  • Agrawal S., Tripathi G., Prajnya R., Sinha N., Gilmour A., Bush L. and Mastana S. 2009 Paraoxonase 1 gene polymorphisms contribute to coronary artery disease risk among north Indians. Indian J. Med. Sci. 63, 335–344.

  • Ahmad I., Narang R., Venkatraman A. and Das N. 2012 Two- and three-locus haplotypes of the paraoxonase (PON1) gene are associated with coronary artery disease in Asian Indians. Gene 506, 242–247.

  • Angeline T., Krithiga H. R., Isabel W., Asirvatham A. J. and Poornima A. 2011 Endothelial nitric oxide synthase gene polymorphism (G894T) and diabetes mellitus (type II) among south Indians. Oxid. Med. Cell Longev. 2011 462607.

  • Bahl V. K., Prabhakaram D. and Karthikeyan G. 2001 Coronary artery disease in Indians. Indian Heart J. 53, 707–713.

  • Banerjee I., Pandey U., Hasan O. M., Parihar R., Tripathi V. and Ganesh S. 2009 Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. J. Thromb. Thrombolysis 27, 88–94.

  • Battes L. C., Cheng J. M., Oemrawsingh R. M., Boersma E., Garcia-Garcia H. M., de Boer S. P. et al. 2014 Circulating cytokines in relation to the extent and composition of coronary atherosclerosis: results from the ATHEROREMO-IVUS study. Atherosclerosis 236, 18–24.

  • Bhanushali A. A. and Das B. R. 2013 Promoter variants in interleukin-6 and tumor necrosis factor alpha and risk of coronary artery disease in a population from western India. Indian J. Hum. Genet. 19, 430–436.

  • Bharatkumar V. P., Nagaraja D. and Christopher R. 2014 Hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T polymorphism in cerebral veno-sinus thrombosis. Clin. Appl. Thromb. Hemost. 20, 78–83.

  • Biswas N. K., Dey B. and Majumder P. P. 2007 Using HapMap data: a cautionary note. Eur. J. Hum. Genet. 15, 246–249.

  • Braun T. R., Been L. F., Singhal A., Worsham J., Ralhan S., Wander G. S. et al. 2012 A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides. PLoS One 7, e37056.

  • Broadbent H. M., Peden J. F., Lorkowski S., Goel A., Ongen H. and Green F. 2008 Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum. Mol. Genet. 17, 806– 814.

  • Chandak G. R., Janipalli C. S., Bhaskar S., Kulkarni S. R., Mohankrishna P. and Hattersley A. T. 2007 Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 50, 63–67.

  • Chandak G. R., Ward K. J., Yajnik C. S., Pandit A. N., Bavdekar A., Joglekar C. V. et al. 2006 Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans. BMC Med. Genet. 7, 76.

  • Chandalia M., Abate N., Garg A., Stray-Gundersen J. and Grundy S. M. 1999 Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J. Clin. Endocrinol. Metab. 84, 2329–2335.

  • Chang S. T., Chen C. L., Chu C. M., Lin P. C., Chung C. M., Hsu J. T. et al. 2006 Ankle-arm index is a useful test for clinical practice in outpatients with suspected coronary artery disease. Circ. J. 70, 686–690.

  • Chhabra S., Narang R., Krishnan L. R., Vasisht S., Agarwal D. P., Srivastava L. M. et al. 2002 Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians. BMC Genet. 3, 9.

  • Congrains A., Kamide K., Oguro R., Yasuda O., Miyata K. and Yamamoto E. 2012 Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B. Atherosclerosis 220, 449–455.

  • Connelly J. J., Shah S. H., Doss J. F., Gadson S., Nelson S., Crosslin D. R. et al. 2008 Genetic and functional association of FAM5C with myocardial infarction. BMC Med. Genet. 9, 33.

  • Consortium I. G. V. 2008 Genetic landscape of the people of India: a canvas for disease gene exploration. J. Genet. 87, 3–18.

  • Consortium I. H. 2005 A haplotype map of the human genome. Nature 437, 1299–1320.

  • Consortium W. T. C. C. 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661–678.

  • Das M., Pal S. and Ghosh A. 2008 Angiotensin converting enzyme gene polymorphism (insertion/deletion) and hypertension in adult Asian Indians: a population-based study from Calcutta, India. Hum. Biol. 80, 303–312.

  • Das M., Pal S. and Ghosh A. 2013 Synergistic effects of ACE (I/D) and Apo E (Hha I) gene polymorphisms on obesity, fat mass, and blood glucose level among the adult Asian Indians: a population-based study from Calcutta, India. Indian J. Endocrinol. Metab. 17, 101–104.

  • de las Fuentes L., Yang W., Davila-Roman V. G. and Gu C. 2012 Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets. Eur. J. Hum. Genet. 20, 1168–1173.

  • Deepa R., Velmurugan K., Saravanan G., Karkuzhali K., Dwarakanath V. and Mohan V. 2001 Absence of association between serum homocysteine levels and coronary artery disease in south Indian males. Indian Heart J. 53, 44–47.

  • Dodani S. 2008 Excess coronary artery disease risk in South Asian immigrants: can dysfunctional high-density lipoprotein explain increased risk? Vasc. Health Risk Manag. 4, 953–961.

  • Elrayess M. A. and Talmud P. J. 2005 Platelet endothelial cell adhesion molecule-1 (PECAM-1) & coronary heart disease. Indian J. Med. Res. 121, 77–79.

  • Enas E. and Senthilkumar A. 2001 Coronary artery disease in Asian Indians: an update and review. Int. J. Cardiol. 1.

  • Enas E. A., Garg A., Davidson M. A., Nair V. M., Huet B. A. and Yusuf S. 1996 Coronary heart disease and its risk factors in first-generation immigrant Asian Indians to the United States of America. Indian Heart J. 48, 343–353.

  • Enas E. A., Yusuf S. and Sharma S. 1998 Coronary artery disease in South Asians. Second meeting of the International Working Group. 16 March 1997, Anaheim, California. Indian Heart J. 50, 105–113.

  • Erdmann J., Grosshennig A., Braund P. S., Konig I. R., Hengstenberg C., Hall A. S. et al. 2009 New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat. Genet. 41, 280–282.

  • Fang L., Wei H., Chowdhury S. H., Gong N., Song J., Heng C. K. et al. 2005 Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians. Indian J. Med. Res. 121, 92–99.

  • Forouhi N. G., Sattar N., Tillin T., McKeigue P. M. and Chaturvedi N. 2006 Do known risk factors explain the higher coronary heart disease mortality in South Asian compared with European men? Prospective follow-up of the Southall and Brent studies, UK. Diabetologia 49, 2580–2588.

  • Girisha K. M., Gilmour A., Mastana S., Singh V. P., Sinha N., Tewari S. et al. 2004 T1 and M1 polymorphism in glutathione S-transferase gene and coronary artery disease in North Indian population. Indian J. Med. Sci. 58, 520–526.

  • Golia E., Limongelli G., Natale F., Fimiani F., Maddaloni V., Pariggiano I. et al. 2014 Inflammation and cardiovascular disease: from pathogenesis to therapeutic target. Curr. Atheroscler Rep. 16, 435.

  • Goyal A. and Yusuf S. 2006 The burden of cardiovascular disease in the Indian subcontinent. Indian J. Med. Res. 124, 235–244.

  • Gupta R. 2008 Recent trends in coronary heart disease epidemiology in India. Indian Heart J. 60, 4–18.

  • Gupta R., Joshi P., Mohan V., Reddy K. S. and Yusuf S. 2008 Epidemiology and causation of coronary heart disease and stroke in India. Heart 94, 16–26.

  • Gupta S. K., Kotwal J., Kotwal A., Dhall A. and Garg S. 2012 Role of homocysteine and MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. Indian J. Med. Res. 135, 506–512.

  • Guptha S., Gupta R., Deedwania P., Bhansali A., Maheshwari A. and Gupta A. 2014 Cholesterol lipoproteins and prevalence of dyslipidemias in urban Asian Indians: a cross-sectional study. Indian Heart J. 66, 280–288.

  • Helgadottir A., Thorleifsson G., Magnusson K. P., Gretarsdottir S., Steinthorsdottir V., Manolescu A. et al. 2008 The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat. Genet. 40, 217–224.

  • Helgadottir A., Thorleifsson G., Manolescu A., Gretarsdottir S., Blondal T., Jonasdottir A. et al. 2007 A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316, 1491–1493.

  • Heng C. K., Low P. S. and Saha N. 2001 Variations in the promoter region of the apolipoprotein A-1 gene influence plasma lipoprotein(a) levels in Asian Indian neonates from Singapore. Pediatr. Res. 49, 514–518.

  • Hinohara K., Nakajima T., Takahashi M., Hohda S., Sasaoka T., Nakahara K. et al. 2008 Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations. J. Hum. Genet. 53, 357–359.

  • Indian Genome Variation 2005 The Indian genome variation database (IGVdb): a project overview. Hum. Genet. 118, 1–11.

  • Jang Y., Kim O. Y., Hyun Y. J., Chae J. S., Koh S. J., Heo Y. M. et al. 2008 Interleukin-6-572C >G polymorphism-association with inflammatory variables in Korean men with coronary artery disease. Transl. Res. 151, 154–161.

  • Jarinova O., Stewart A. F., Roberts R., Wells G., Lau P., Naing T. et al. 2009 Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler. Thromb. Vasc. Biol. 29, 1671–1677.

  • Jayasinghe S. R. and Jayasinghe S. H. 2009 Variant metabolic risk factor profile leading to premature coronary disease: time to define the syndrome of accelerated atherocoronary metabolic syndrome in Asian Indians. Singapore Med. J. 50, 949–955.

  • Kanjilal S., Shanker J., Rao V. S., Khadrinarasimhaih N. B., Mukherjee M., Iyengar S. S. and Kakkar V. V. 2008 Prevalence and component analysis of metabolic syndrome: an Indian atherosclerosis research study perspective. Vasc. Health Risk Manag. 4, 189–197.

  • Kathiresan S. 2008 A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. N. Engl. J. Med. 358, 2299–2300.

  • Kathiresan S., Melander O., Anevski D., Guiducci C., Burtt N. P., Roos C. et al. 2008 Polymorphisms associated with cholesterol and risk of cardiovascular events. N. Engl. J. Med. 358, 1240–1249.

  • Kaya Y., Cebi A., Soylemez N., Demir H., Alp H. H. and Bakan E. 2012 Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease. Int. J. Med. Sci. 9, 621–626.

  • Klatsky A. L. and Tekawa I. 2005 Health problems and hospitalizations among Asian–American ethnic groups. Ethn. Dis. 15, 753–760.

  • Klein R. J., Zeiss C., Chew E. Y., Tsai J. Y., Sackler R. S., Haynes C. et al. 2005 Complement factor H polymorphism in age-related macular degeneration. Science 308, 385–389.

  • Kumar J., Das S. K., Sharma P., Karthikeyan G., Ramakrishnan L. and Sengupta S. 2005 Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population. J. Hum. Genet. 50, 655–663.

  • Kumar J., Yumnam S., Basu T., Ghosh A., Garg G., Karthikeyan G. and Sengupta S. 2011 Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS. Clin. Genet. 79, 588–593.

  • Lai C. Q., Tai E. S., Tan C. E., Cutter J., Chew S. K., Zhu Y. P. et al. 2003 The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore. J. Lipid Res. 44, 2365–2373.

  • Lee J. W., Brancati F. L. and Yeh H. C. 2011 Trends in the prevalence of type 2 diabetes in Asians versus whites: results from the United States National Health Interview Survey, 1997–2008. Diabetes Care 34, 353–357.

  • Li M., Reilly M. P., Rader D. J. and Wang L. S. 2010 Correcting population stratification in genetic association studies using a phylogenetic approach. Bioinformatics 26, 798–806.

  • Libby P., Ridker P. M. and Maseri A. 2002 Inflammation and atherosclerosis. Circulation 105, 1135–1143.

  • Liem S. S., Oemrawsingh P. V., Cannegieter S. C., Le Cessie S., Schreur J., Rosendaal F. R. and Schalij M. J. 2009 Cardiovascular risk in young apparently healthy descendents from Asian Indian migrants in the Netherlands: the SHIVA study. Neth. Heart J. 17, 155–161.

  • Liu Y., Ordovas J. M., Gao G., Province M., Straka R. J., Tsai M. Y. et al. 2009 Pharmacogenetic association of the APOA1/C3/A4/ A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study. Pharmacogenet. Genomics 19, 161–169.

  • Lusis A. J. 2000 Atherosclerosis. Nature 407, 233–241.

  • Mahajan A., Jaiswal A., Tabassum R., Podder A., Ghosh S., Madhu S. V. et al. 2012 Elevated levels of C-reactive protein as a risk factor for metabolic syndrome in Indians. Atherosclerosis 220, 275–281.

  • Maitra A., Dash D., John S., Sannappa P. R., Das A. P., Shanker J. et al. 2009 A common variant in chromosome 9p21 associated with coronary artery disease in Asian Indians. J. Genet. 88, 113–118.

  • Maitra A., Shanker J., Dash D., John S., Sannappa P. R., Rao V. S. et al. 2008 Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease the Indian Atherosclerosis Research Study. Thromb. Haemost. 99, 944–950.

  • Markan S., Sachdeva M., Sehrawat B. S., Kumari S., Jain S. and Khullar M. 2007 MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Mol. Cell Biochem. 302, 125–131.

  • Misra A. and Khurana L. 2009 The metabolic syndrome in South Asians: epidemiology, determinants, and prevention. Metab. Syndr. Relat. Disord. 7, 497–514.

  • Misra A. and Vikram N. K. 2004 Insulin resistance syndrome (metabolic syndrome) and obesity in Asian Indians: evidence and implications. Nutrition 20, 482–491.

  • Mohan V., Deepa R., Velmurugan K. and Premalatha G. 2005 Association of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6). Diabet. Med. 22, 863–870.

  • Mukherjee M., Joshi S., Bagadi S., Dalvi M., Rao A. and Shetty K. R. 2002 A low prevalence of the C677T mutation in the methylenetetrahydrofolate reductase gene in Asian Indians. Clin. Genet. 61, 155–159.

  • Mukherjee M. and Shetty K. R. 2004 Variations in high-density lipoprotein cholesterol in relation to physical activity and Taq 1B polymorphism of the cholesteryl ester transfer protein gene. Clin. Genet. 65, 412–418.

  • Murray C. J. and Lopez A. D. 1997 Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet 349, 1498–1504.

  • Nadeem M., Ahmed S. S., Mansoor S. and Farooq S. 2013 Risk factors for coronary heart disease in patients below 45 years of age. Pak. J. Med. Sci. 29, 91–96.

  • Nair K. G., Nair S. R., Ashavaid T. F., Dalal J. J. and Eghlim F. F. 2002 Methylenetetrahydrofolate reductase gene mutation and hyperhomocysteinemia as a risk factor for coronary heart disease in the Indian population. J. Assoc. Physicians India 50 suppl, 9–15.

  • Nejatizadeh A., Kumar R., Stobdan T., Goyal A.K., Sikdar S. and Gupta M. 2008 Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension. Free Radic. Biol. Med. 44, 1912–1918.

  • Ng S. C., Tsoi K. K., Kamm M. A., Xia B., Wu J., Chan F. K. and Sung J. J. 2012 Genetics of inflammatory bowel disease in Asia: systematic review and meta-analysis. Inflamm. Bowel Dis. 18, 1164–1176.

  • Padmaja N., Kumar R. M., Balachander J. and Adithan C. 2009 Cholesteryl ester transfer protein TaqIB, -629C >A and I405V polymorphisms and risk of coronary heart disease in an Indian population. Clin. Chim. Acta 402, 139–145.

  • Patel J. V., Dwivedi S., Hughes E. A. and Lip G. Y. 2008 Premature coronary artery disease: an inferred cardiovascular variant or a South Asian genetic disorder Thromb. Haemost. 99, 991–992.

  • Paul T. K., Srinivasan S. R., Wei C., Li S., Bhuiyan A. R., Bond M. G. et al. 2005 Cardiovascular risk profile of asymptomatic healthy young adults with increased femoral artery intima-media thickness: The Bogalusa Heart Study. Am. J. Med. Sci. 330, 105–110.

  • Periaswamy R., Gurusamy U., Shewade D. G., Cherian A., Swaminathan R. P., Dutta T. K. et al. 2008 Gender specific association of endothelial nitric oxide synthase gene (Glu298Asp) polymorphism with essential hypertension in a south Indian population. Clin. Chim. Acta 395, 134–136.

  • Prasad P., Kumar K. M., Ammini A. C., Gupta A., Gupta R. and Thelma B. K. 2008 Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. BMC Genet. 9, 26.

  • Radha V. and Mohan V. 2007 Genetic predisposition to type 2 diabetes among Asian Indians. Indian J. Med. Res. 125, 259–274.

  • Radha V., Mohan V., Vidya R., Ashok A. K., Deepa R. and Mathias R. A. 2006a Association of lipoprotein lipase Hind III and Ser 447 Ter polymorphisms with dyslipidemia in Asian Indians. Am. J. Cardiol. 97, 1337–1342.

  • Radha V., Vimaleswaran K. S., Babu H. N., Abate N., Chandalia M., Satija P. et al. 2006b Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: evidence for heterogeneity. Diabetes Care 29, 1046–1051.

  • Rai T. S., Khullar M., Sehrawat B. S., Ahuja M., Sharma P. K., Vijayvergiya R. and Grover A. 2008 Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease. Mol. Cell Biochem. 313, 139–146.

  • Ramachandran A., Snehalatha C. and Vijay V. 2004 Low risk threshold for acquired diabetogenic factors in Asian Indians. Diabetes Res. Clin. Pract. 65, 189–195.

  • Ramya K., Ayyappa K.A., Ghosh S., Mohan V. and Radha V. 2013 Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population. Gene 532, 253–262.

  • Ranjith N., Pegoraro R. J., Rom L., Rajput M. C. and Naidoo D. P. 2004 Lp(a) and apoE polymorphisms in young South African Indians with myocardial infarction. Cardiovasc. J. S. Afr. 15, 111–117.

  • Rao V. S., Kadarinarasimhiah N. B., John S., Hebbagodi S., Shanker J. and Kakkar V. V. 2010 Usefulness of C-reactive protein as a marker for prediction of future coronary events in the Asian Indian population: Indian atherosclerosis research study. Int. J. Vasc. Med. 2010, 389235.

  • Reddy S. T., Devarajan A., Bourquard N., Shih D. and Fogelman A. M. 2008 Is it just paraoxonase 1 or are other members of the paraoxonase gene family implicated in atherosclerosis? Curr. Opin. Lipidol. 19, 405–408.

  • Reiner A. P., Wurfel M. M., Lange L. A., Carlson C. S., Nord A. S., Carty C. L. et al. 2008 Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation. Arterioscler. Thromb. Vasc. Biol. 28, 1407–1412.

  • Ridker P. M., Pare G., Parker A., Zee R. Y., Danik J. S., Buring J. E. et al. 2008 Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women’s Genome Health Study. Am. J. Hum. Genet. 82, 1185–1192.

  • Samani N. J., Erdmann J., Hall A. S., Hengstenberg C., Mangino M., Mayer B. et al. 2007 Genomewide association analysis of coronary artery disease. N. Engl. J. Med. 357, 443–453.

  • Sanghera D. K., Aston C. E., Saha N. and Kamboh M. I. 1998 DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease. Am. J. Hum. Genet. 62, 36–44.

  • Sankar V. H., Girisha K. M., Gilmour A., Singh V. P., Sinha N., Tewari S. et al. 2005 TNFR2 gene polymorphism in coronary artery disease. Indian J. Med. Sci. 59, 104–108.

  • Sarkar Roy N., Farheen S., Roy N., Sengupta S. and Majumder P. P. 2008 Portability of tag SNPs across isolated population groups: an example from India. Ann. Hum. Genet. 72, 82–89.

  • Schierer A., Been L. F., Ralhan S., Wander G. S., Aston C. E. and Sanghera D. K. 2012 Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort. Pharmacogenet. Genomics 22, 95–104.

  • Shah S. H., Freedman N. J., Zhang L., Crosslin D. R., Stone D. H., Haynes C. et al. 2009 Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. PLoS Genet. 5, e1000318.

  • Shanker J., Arvind P., Jambunathan S., Nair J. and Kakkar V. 2014 Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians. Thromb. Haemost. 111, 960–969.

  • Shanker J., Kanjilal S., Rao V. S., Perumal G., Khadrinarasimhiah N. B., Mukherjee M. et al. 2007 Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: the Indian Atherosclerosis Research Study. Vasc. Health Risk Manag. 3, 1063–1068.

  • Shanker J., Maitra A., Rao V. S., Mundkur L., Dhanalakshmi B., Hebbagodi S. and Kakkar V. V. 2010 Rationale, design & preliminary findings of the Indian Atherosclerosis Research Study. Indian Heart J. 62, 286–295.

  • Shanker J., Perumal G., Rao V. S., Khadrinarasimhiah N. B., John S., Hebbagodi S. et al. 2008 Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. Lipids Health Dis. 7, 33.

  • Sharda S., Gilmour A., Harris V., Singh V. P., Sinha N., Tewari S. et al. 2008 Chemokine receptor 5 (CCR5) deletion polymorphism in North Indian patients with coronary artery disease. Int. J. Cardiol. 124, 254–258.

  • Sharma M. and Ganguly N. K. 2005 Premature coronary artery disease in Indians and its associated risk factors. Vasc. Health Risk Manag. 1, 217–225.

  • Sharma P., Kumar J., Garg G., Kumar A., Patowary A., Karthikeyan G. et al. 2008 Detection of altered global DNA methylation in coronary artery disease patients. DNA Cell Biol. 27, 357–365.

  • Shen G. Q., Li L., Rao S., Abdullah K. G., Ban J. M., Lee B. S. et al. 2008 Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 28, 360–365.

  • Sheth T., Nair C., Nargundkar M., Anand S. and Yusuf S. 1999 Cardiovascular and cancer mortality among Canadians of European, south Asian and Chinese origin from 1979 to 1993: an analysis of 1.2 million deaths. CMAJ 161, 132–138.

  • Shishehbor M. H. and Bhatt D. L. 2004 Inflammation and atherosclerosis. Curr. Atheroscler. Rep. 6, 131–139.

  • Singh S., Venketesh S., Verma J. S., Verma M., Lellamma C. O. and Goel R. C. 2007 Paraoxonase (PON1) activity in north west Indian Punjabis with coronary artery disease & type 2 diabetes mellitus. Indian J. Med. Res. 125, 783–787.

  • Slack J. and Evans K. A. 1966 The increased risk of death from ischaemic heart disease in first degree relatives of 121 men and 96 women with ischaemic heart disease. J. Med. Genet. 3, 239–257.

  • Tai E. S., Corella D., Deurenberg-Yap M., Cutter J., Chew S. K., Tan C. E. and Ordovas J. M. 2003a Dietary fat interacts with the −514C >T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey. J. Nutr. 133, 3399–3408.

  • Tai E. S., Ordovas J. M., Corella D., Deurenberg-Yap M., Chan E., Adiconis X. et al. 2003b The TaqIB and –629C >A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey. Clin. Genet. 63, 19–30.

  • Tan J. H., Low P S., Tan Y. S., Tong M. C., Saha N., Yang H. and Heng C. K. 2003 ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore. Hum. Genet. 113, 106–117.

  • Tan S. T., Scott W., Panoulas V., Sehmi J., Zhang W., Scott J., Elliott P. et al. 2014 Coronary heart disease in Indian Asians. Glob. Cardiol. Sci. Pract. 2014, 13–23.

  • Tillin T., Dhutia H., Chambers J., Malik I., Coady E., Mayet J. et al. 2007 South Asian men have different patterns of coronary artery disease when compared with European men. Int. J. Cardiol. 129, 406–413.

  • Tonjes A. and Stumvoll M. 2007 The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk. Curr. Opin. Clin. Nutr. Metab. Care 10, 410–414.

  • Tregouet D. A., Konig I. R., Erdmann J., Munteanu A., Braund P. S., Hall A. S. et al. 2009 Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat. Genet. 41, 283–285.

  • Tuomisto K., Jousilahti P., Sundvall J., Pajunen P. and Salomaa V. 2006 C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study. Thromb. Haemost. 95, 511–518.

  • Varga E. A., Sturm A. C., Misita C. P. and Moll S. 2005 Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease. Circulation 111, e289–e293.

  • Vickers M. A., Green F. R., Terry C., Mayosi B. M., Julier C., Lathrop M. et al. 2002 Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc. Res. 53, 1029–1034.

  • Vimaleswaran K. S., Radha V., Ghosh S., Majumder P. P., Deepa R., Babu H. N. et al. 2005 Peroxisome proliferator- activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians. Diabet. Med. 22, 1516–1521.

  • Vimaleswaran K. S., Radha V., Ramya K., Babu H. N., Savitha N., Roopa V. et al. 2008 A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians. Hum. Genet. 123, 599–605.

  • Vinukonda G., Shaik Mohammad N., Md Nurul Jain J., Prasad Chintakindi K. and Rama Devi Akella R. 2009 Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians. Clin. Chim. Acta 405, 127–131.

  • Wang X. H., Liu S. Q., Wang Y. L. and Jin Y. 2014 Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome. Genet. Mol. Res. 13, 4260–4266.

  • Wilson M. H., Grant P. J., Kain K., Warner D. P. and Wild C. P. 2003 Association between the risk of coronary artery disease in South Asians and a deletion polymorphism in glutathione S-transferase M1. Biomarkers 8, 43–50.

  • World Health Organization 2005 Preventing chronic diseases : a vital investment. World Health Organization, Geneva, Switzerland.

  • Yin Y. W., Li J. C., Zhang M., Wang J. Z., Li B. H., Liu Y. et al. 2013 Influence of interleukin-6 gene −174G >C polymorphism on development of atherosclerosis: a meta-analysis of 50 studies involving 33,514 subjects. Gene 529, 94–103.

  • Yusuf S., Hawken S., Ounpuu S., Dans T., Avezum A., Lanas F. et al. 2004 Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364, 937–952.

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Acknowledgements

We gratefully acknowledge the support and encouragement given by the Trustees of the Thrombosis Research Institutes in London and India. We are grateful to the Tata Social Welfare Trust, the Department of Biotechnology, Government of India, Weston Foundation, UK, Emmanuel Kaye foundation, UK and Foundation Bay, Switzerland for their financial assistance towards the Indian Atherosclerosis Research Study. We thank Dr Srikarthika Jambunathan, Research Scientist, Mary and Garry Weston Functional Genomics unit for her editorial assistance.

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  1. Functional Genomics Thrombosis Research Institute, Bengaluru, 560 099, India

    SHANKER JAYASHREE & KAKKAR V. VIJAY

  2. National Institute of Biomedical Genomics, Kalyani, 741 251, India

    MAITRA ARINDAM

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  1. SHANKER JAYASHREE
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  2. MAITRA ARINDAM
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  3. KAKKAR V. VIJAY
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Correspondence to SHANKER JAYASHREE.

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[Jayashree S., Arindam M. and Vijay K. V. 2015 Genetic epidemiology of coronary artery disease: an Asian Indian perspective. J. Genet. 94, xx–xx]

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JAYASHREE, S., ARINDAM, M. & VIJAY, K.V. Genetic epidemiology of coronary artery disease: an Asian Indian perspective. J Genet 94, 539–549 (2015). https://doi.org/10.1007/s12041-015-0547-4

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