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Elevated expression of IMPDH2 is associated with progression of kidney and bladder cancer

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Abstract

Novel molecular markers for cancer progression are valuable for the diagnosis and evaluation of treatment efficacies of the diseases. Expression of inosine 5′-monophosphate dehydrogenase type II (IMPDH2), a rate-limiting enzyme in the de novo guanine nucleotide biosynthesis, is up-regulated in various neoplasms, including prostate cancer and patient serum. However, whether IMPDH2 can serve as a biomarker for other urologic cancers is unknown. Paired patient tissue macroarrays were analyzed by immunohistochemistry, the IMPDH2 protein expression in these tissues was quantitated and expressed as immunoreactivity scores. Compared with non-cancerous tissues, IMPDH2 protein expression levels were significantly upregulated in kidney and bladder cancer, but no difference in testis cancer. In addition, expression of IMPDH2 was not associated with the disease clinical stages and pathological features. The findings suggest that overexpressed IMPDH2 can be used as a biomarker for kidney and bladder cancer diagnosis and is a potential therapeutic target for the diseases.

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Acknowledgments

This work was supported by grants from National Natural Science Foundation of China (81170699, 81272813, 81200550, 81470983, 81101712), Science and Technology Project of Guangdong Province (2013B021800055), Guangzhou Municipal Science and Technology Key Project (2014J4100072), Projects of Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics.

Conflict of interest

The authors declare that they have no conflict of interests.

Author information

Authors and Affiliations

  1. Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou, 510515, China

    Jun Zou, Chao Cai, Hongwei Luo, Yaqiang Huang & Weide Zhong

  2. Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, 510180, China

    Jun Zou, Zhaodong Han, Liang Zhou, Yuxiang Liang, Huichan He, Funeng Jiang & Weide Zhong

  3. The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China

    Jun Zou

  4. School of Pharmacy, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China

    Cong Wang

  5. Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China

    Weide Zhong

  6. Department of Urology, Huadu District People’s Hospital, Southern Medical University, Guangzhou, 510800, China

    Weide Zhong

Authors
  1. Jun Zou
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  2. Zhaodong Han
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  3. Liang Zhou
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  4. Chao Cai
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  5. Hongwei Luo
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  6. Yaqiang Huang
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  7. Yuxiang Liang
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  8. Huichan He
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  9. Funeng Jiang
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  10. Cong Wang
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  11. Weide Zhong
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Corresponding authors

Correspondence to Cong Wang or Weide Zhong.

Additional information

Jun Zou, Zhaodong Han and Liang Zhou have contributed equally to this work.

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Zou, J., Han, Z., Zhou, L. et al. Elevated expression of IMPDH2 is associated with progression of kidney and bladder cancer. Med Oncol 32, 373 (2015). https://doi.org/10.1007/s12032-014-0373-1

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  • DOI: https://doi.org/10.1007/s12032-014-0373-1

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