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Small Cell Carcinoma of the Gall Bladder: Role of Adjuvant Chemotherapy

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Abstract

Introduction

Small cell cancer of the gallbladder is a rare malignancy with a poor prognosis. There is limited information in the literature on the best therapeutic approach towards this cancer with anecdotal therapy extrapolated from experience in small cell cancer of the lung.

Case Report

We are presenting a 70-year-old woman with this cancer who is undergoing multimodality treatment, along with a review of literature on previously reported cases.

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References

  1. van der Heijden HF, Heijdra YF. Extrapulmonary small cell carcinoma. South Med J. 2005;98:345–9.

    Article  PubMed  Google Scholar 

  2. Mckeown F. Oat-cell carcinoma of the esophagus. J Pathol Bacteriol. 1952;80:889–91.

    Article  Google Scholar 

  3. Brenner B, Tang LH, Klimstra DS, et al. Small-cell carcinomas of the gastrointestinal tract: a review. J Clin Oncol. 2004;22:2730–9.

    Article  PubMed  Google Scholar 

  4. Albores-Saavedra J, Cruz-Ortiz H, Alcantara-Vazques A, et al. Unusual types of gallbladder carcinoma. A report of 16 cases. Arch Pathol Lab Med. 1981;105:287–93.

    CAS  PubMed  Google Scholar 

  5. Bahadur S, Shaukat A, Gibbs J, et al. Cisplatin and gemcitabine for small cell carcinoma of the gall bladder. Am J Clin Oncol. 2005;28:425–6.

    Article  PubMed  Google Scholar 

  6. Moskal TL, Zhang PJ, Nava HR. Small cell carcinoma of the gallbladder. J Surg Oncol. 1999;70:54–9.

    Article  CAS  PubMed  Google Scholar 

  7. Guo KJ, Yamaguchi K, Enjoji M. Undifferentiated carcinoma of the gallbladder. A clinicopathologic, histochemical, and immunohistochemical study of 21 patients with a poor prognosis. Cancer. 1988;61:1872–9.

    Article  CAS  PubMed  Google Scholar 

  8. Albores-Saavedra J, Soriano J, Larraza-Hernandez O, et al. Oat cell carcinoma of the gallbladder. Hum Pathol. 1984;15:639–46.

    Article  CAS  PubMed  Google Scholar 

  9. Friedman MD, Wheeler WE. Cancer of the gallbladder. South Med J. 1990;83:485–6.

    CAS  PubMed  Google Scholar 

  10. Cavazzana AO, Fassina AS, Tollot M, et al. Small-cell carcinoma of gallbladder. An immunocytochemical and ultrastructural study. Pathol Res Pract. 1991;187:472–6.

    CAS  PubMed  Google Scholar 

  11. Iida Y, Tsutsumi Y. Small cell (endocrine cell) carcinoma of the gallbladder with squamous and adenocarcinomatous components. Acta Pathol Jpn. 1992;42:119–25.

    CAS  PubMed  Google Scholar 

  12. Ron IG, Wigler N, Ilie B, Chaitchik S. Small cell carcinoma of the gallbladder: clinical course and response to chemotherapy. Tumori. 1992;78:207–10.

    CAS  PubMed  Google Scholar 

  13. Johnstone AK, Zuch RH, Anders KH. Oat cell carcinoma of the gallbladder. A rare and highly lethal neoplasm. Arch Pathol Lab Med. 1993;117:1009–12.

    CAS  PubMed  Google Scholar 

  14. Nishihara K, Tsuneyoshi M. Undifferentiated spindle cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and flow cytometric study of 11 cases. Hum Pathol. 1993;24:1298–305.

    Article  CAS  PubMed  Google Scholar 

  15. Muraina OI, Tank R, Dhingra C, Vuletin JC, Colella F, Abdelsayed G, et al. Small cell carcinoma of gallbladder: report of two cases. Am J Gastroenterol. 1996;91:792–4.

    CAS  PubMed  Google Scholar 

  16. Debois JM, De Vriendt P, Charels K. Small cell carcinoma of the gallbladder. Acta Chir Belg. 1998;98:110–2.

    CAS  PubMed  Google Scholar 

  17. Kuwabara H, Uda H. Small cell carcinoma of the gall-bladder with intestinal metaplastic epithelium. Pathol Int. 1998;48:303–6.

    Article  CAS  PubMed  Google Scholar 

  18. Matsuo S, Shinozaki T, Yamaguchi S, et al. Small-cell carcinoma of the gallbladder: report of a case. Surg Today. 2000;30:89–93.

    Article  CAS  PubMed  Google Scholar 

  19. Maitra A, Tascilar M, Hruban RH, et al. Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases. Am J Surg Pathol. 2001;25:595–601.

    Article  CAS  PubMed  Google Scholar 

  20. Fujii H, Aotake T, Horiuchi T, et al. Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature. Hepatogastroenterology. 2001;48:1588–93.

    CAS  PubMed  Google Scholar 

  21. Lane JE, Walker AN, Ayers GW, et al. Small-cell undifferentiated carcinoma of neuroendocrine type originating in the gallbladder. Curr Surg. 2002;59:495–7.

    Article  PubMed  Google Scholar 

  22. Jun SR, Lee JM, Han JK, et al. High-grade neuroendocrine carcinomas of the gallbladder and bile duct: Report of four cases with pathological correlation. J Comput Assist Tomogr. 2006;30:604–9.

    Article  PubMed  Google Scholar 

  23. Imai H, Matsui S, Tokuyama Y, et al. Small cell carcinoma of the gallbladder successfully treated by surgery and adjuvant chemotherapy. Am Surg. 2008;74:272–3.

    PubMed  Google Scholar 

  24. Iype S, Mirza TA, Propper DJ, et al. Neuroendocrine tumours of the gallbladder: three cases and a review of the literature. Postgrad Med J. 2009;85:213–8.

    Article  CAS  PubMed  Google Scholar 

  25. Uribe-Uribe NO, Jimenez-Garduño AM, Henson DE, et al. Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder. Ann Diagn Pathol. 2009;13:124–6.

    Article  PubMed  Google Scholar 

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Correspondence to Saad Usmani.

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Usmani, S., Pazooki, M. & Bilgrami, S.F. Small Cell Carcinoma of the Gall Bladder: Role of Adjuvant Chemotherapy. J Gastrointest Canc 41, 84–87 (2010). https://doi.org/10.1007/s12029-009-9122-7

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