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Regulation of NF-κB induction by TCR/CD28

  • UNIVERSITY OF PITTSBURGH IMMUNOLOGY 2011
  • Published:
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Abstract

NF-κB family transcription factors are a common downstream target for inducible transcription mediated by many different cell-surface receptors, especially those receptors involved in inflammation and adaptive immunity. It is now clear that different classes of receptors employ different proximal signaling strategies to activate the common NF-κB signaling components, such as the IKK complex. For antigen receptors expressed by T and B cells, this pathway requires a complex of proteins including the proteins Carma1, Bcl10, and Malt1. Here, we discuss some of what is known about regulation of these proteins downstream of TCR/CD3 and co-stimulatory CD28 signaling. We also discuss another unique aspect of TCR-mediated NF-κB activation, i.e., the spatial restriction imposed on signaling events by the formation of the immunological synapse between a T cell and antigen-presenting cell presenting specific peptide/MHC.

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Authors and Affiliations

  1. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA

    Jing Cheng, Angela Montecalvo & Lawrence P. Kane

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  1. Jing Cheng
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  2. Angela Montecalvo
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  3. Lawrence P. Kane
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Correspondence to Lawrence P. Kane.

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Cheng, J., Montecalvo, A. & Kane, L.P. Regulation of NF-κB induction by TCR/CD28. Immunol Res 50, 113–117 (2011). https://doi.org/10.1007/s12026-011-8216-z

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  • DOI: https://doi.org/10.1007/s12026-011-8216-z

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