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Quiescent T cells and HIV: an unresolved relationship

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Abstract

The ability of HIV to infect quiescent CD4+ T cells has been a topic of intense debate. While early studies suggested that the virus could not infect this particular T cell subset, subsequent studies using more sensitive protocols demonstrated that these cells could inefficiently support HIV infection. Additional studies showed that the kinetics of infection in quiescent cells was delayed and multiple stages of the viral life cycle were marred by inefficiencies. Despite that, proviral DNA has been found in these cells presenting them as a potential viral reservoir. Therefore, a better understanding of the relationship between HIV and quiescent T cells may lead to further advances in the field of HIV.

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Acknowledgments

This work was supported by NIH grants AI070010, and UCLA CFAR (AI28697).

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, UCLA AIDS Institute, 615 Charles E. Young Drive South, BSRB 173, Mailcode 736322, Los Angeles, CA, 90095, USA

    Dimitrios N. Vatakis & Jerome A. Zack

  2. Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, UCLA AIDS Institute, 615 Charles E. Young Drive South, BSRB 173, Mailcode 736322, Los Angeles, CA, 90095, USA

    Christopher C. Nixon & Jerome A. Zack

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  1. Dimitrios N. Vatakis
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Correspondence to Dimitrios N. Vatakis.

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Vatakis, D.N., Nixon, C.C. & Zack, J.A. Quiescent T cells and HIV: an unresolved relationship. Immunol Res 48, 110–121 (2010). https://doi.org/10.1007/s12026-010-8171-0

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