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Evaluating the Suitability of Postnuclear Supernatants as In Vitro Models for Assessing Cadmium- and Other Xenobiotic-Induced Neurotoxicity on Crucial Enzymatic Parameters

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References

  1. Govil N, Chaudhary S, Waseem M, Parvez S (2012) Postnuclear supernatant: an in vitro model for assessing cadmium-induced neurotoxicity. Biol Trace Elem Res 146:402–409

    Article  PubMed  CAS  Google Scholar 

  2. Carageorgiou H, Tzotzes V, Pantos C, Mourouzis C, Zarros A, Tsakiris S (2004) In vivo and in vitro effects of cadmium on adult rat brain total antioxidant status, acetylcholinesterase, (Na+, K+)-ATPase and Mg2+-ATPase activities: protection by L-cysteine. Basic Clin Pharmacol Toxicol 94:112–118

    Article  PubMed  CAS  Google Scholar 

  3. Schulpis KH, Kalimeris K, Bakogiannis C, Tsakiris T, Tsakiris S (2006) The effect of in vitro homocystinuria on the suckling rat hippocampal acetylcholinesterase. Metab Brain Dis 21:21–28

    Article  PubMed  CAS  Google Scholar 

  4. Simintzi I, Schulpis KH, Angelogianni P, Liapi C, Tsakiris S (2007) The effect of aspartame metabolites on the suckling rat frontal cortex acetylcholinesterase. An in vitro study. Food Chem Toxicol 45:2397–2401

    Article  PubMed  CAS  Google Scholar 

  5. Zarros A, Theocharis S, Skandali N, Tsakiris S (2008) Effects of fulminant hepatic encephalopathy on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na+, K+)-and Mg2+-ATPase: comparison of the enzymes’ response to in vitro treatment with ammonia. Metab Brain Dis 23:255–264

    Article  PubMed  CAS  Google Scholar 

  6. Sgaravatti AM, Vargas BA, Zandoná BR, Deckmann KB, Rockenbach FJ, Moraes TB, Monserrat JM, Sgarbi MB, Pederzolli CD, Wyse AT, Wannmacher CM, Wajner M, Dutra-Filho CS (2008) Tyrosine promotes oxidative stress in cerebral cortex of young rats. Int J Dev Neurosci 26:551–559

    Article  PubMed  CAS  Google Scholar 

  7. Moraes TB, Zanin F, da Rosa A, de Oliveira A, Coelho J, Petrillo F, Wajner M, Dutra-Filho CS (2010) Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain. J Neurol Sci 292:89–95

    Article  PubMed  CAS  Google Scholar 

  8. Fernandes CG, Leipnitz G, Seminotti B, Amaral AU, Zanatta A, Vargas CR, Dutra Filho CS, Wajner M (2010) Experimental evidence that phenylalanine provokes oxidative stress in hippocampus and cerebral cortex of developing rats. Cell Mol Neurobiol 30:317–326

    Article  PubMed  CAS  Google Scholar 

  9. Skrzycki M, Czeczot H, Majewska M, Podsiad M, Karlik W, Grono D, Wiechetek M (2010) Enzymatic antioxidant defense in isolated rat hepatocytes exposed to cadmium. Pol J Vet Sci 13:673–679

    PubMed  CAS  Google Scholar 

  10. Xie HR, Hu LS, Li GY (2010) SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson’s disease. Chin Med J (Engl) 123:1086–1092

    CAS  Google Scholar 

  11. Chan KH, Lam KS, Cheng OY, Kwan JS, Ho PW, Cheng KK, Chung SK, Ho JW, Guo VY, Xu A (2012) Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity. PLoS One 7:e52354

    Article  PubMed  CAS  Google Scholar 

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Conflict of interest

All authors (AZ, RTC, ST, and GSB) declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Gardiner Laboratory (535), Wolfson Link Building, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Box 318, 111 West George str., G2-1QX, Glasgow, Scotland, UK

    Apostolos Zarros, Ryan T. Cameron & George S. Baillie

  2. Laboratory of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Hellenic Republic

    Apostolos Zarros & Stylianos Tsakiris

Authors
  1. Apostolos Zarros
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  2. Ryan T. Cameron
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  3. Stylianos Tsakiris
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  4. George S. Baillie
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Correspondence to Apostolos Zarros.

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Zarros, A., Cameron, R.T., Tsakiris, S. et al. Evaluating the Suitability of Postnuclear Supernatants as In Vitro Models for Assessing Cadmium- and Other Xenobiotic-Induced Neurotoxicity on Crucial Enzymatic Parameters. Biol Trace Elem Res 152, 297–299 (2013). https://doi.org/10.1007/s12011-013-9626-7

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  • DOI: https://doi.org/10.1007/s12011-013-9626-7

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