Skip to main content

Advertisement

Log in

Which Patients Are at Risk for Kidney Dysfunction After Hip Fracture Surgery?

  • Symposium: 2012 International Hip Society Proceedings
  • Published:
Clinical Orthopaedics and Related Research®

Abstract

Background

Kidney dysfunction (KD) after hip fracture surgery is a major complication. However, the incidence and risk factors of KD in this population are unclear.

Questions/purposes

We therefore (1) determined the incidence of KD in a large cohort of fracture patients, (2) identified preoperative risk factors predisposing to KD, and (3) determined the effect of KD on length of stay and subsequent function.

Methods

Between April 2011 and June 2012, 450 patients (263 women) with a mean age of 73 years (range, 67–96 years) underwent surgery for hip fracture in our institution. We calculated incidence and retrospectively reviewed suspected predisposing risk factors. We report followup at 6 months.

Results

The overall incidence of KD was 11% (n = 52). Forty-five patients (86%) developed acute KD and seven patients developed acute-on-chronic KD. Three of the 52 patients died during the followup time. Thirty-eight of the 52 patients (73%) regained their prior kidney function after treatment. An increased risk of KD was found in those with diabetes, shock during or after surgery, age, and preexisting KD. Mean length of stay was higher for patients with KD compared to those without: 9.6 versus 7.4, respectively. At 6 months, 39 of the 49 surviving patients (80%) were fully weightbearing.

Conclusions

Many patients at risk for postoperative KD can be identified and treated. Most patients recover from their KD and the majority return to full weightbearing.

Level of Evidence

Level III, prognostic study. See Instructions for Authors for a complete description of levels of evidence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Abelha FJ, Botelho M, Fernandes V, Barros H. Outcome and quality of life of patients with acute kidney injury after major surgery. Nefrologia. 2009;29:404–414.

    PubMed  CAS  Google Scholar 

  2. Ackland GL, Moran N, Cone S, Grocott MP, Mythen MG. Chronic kidney disease and postoperative morbidity after elective orthopedic surgery. Anesth Analg. 2011;112:1375–1381.

    Article  PubMed  Google Scholar 

  3. Antonelli Incalzi R, Gemma A, Capparella O, Terranova L, Sanguinetti C, Carbonin PU. Post-operative electrolyte imbalance: its incidence and prognostic implications for elderly orthopaedic patients. Age Ageing. 1993;22:325–331.

    Article  PubMed  CAS  Google Scholar 

  4. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; Acute Dialysis Quality Initiative workgroup. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8:R204–R212.

    Article  PubMed  Google Scholar 

  5. Bennet SJ, Berry OM, Goddard J, Keating JF. Acute renal dysfunction following hip fracture. Injury. 2010;41:335–338.

    Article  PubMed  Google Scholar 

  6. Bhattacharyya T, Iorio R, Healy WL. Rate of and risk factors for acute inpatient mortality after orthopaedic surgery. J Bone Joint Surg Am. 2002;84:562–572.

    PubMed  Google Scholar 

  7. Bukata SV, Kates SL, O’Keefe RJ. Short-term and long-term orthopaedic issues in patients with fragility fractures. Clin Orthop Relat Res. 2011;469:2225–2236.

    Article  PubMed  Google Scholar 

  8. Carmichael P, Carmichael AR. Acute renal failure in the surgical setting. ANZ J Surg. 2003;73:144–153.

    Article  PubMed  Google Scholar 

  9. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16:3365–3370.

    Article  PubMed  Google Scholar 

  10. Haentjens P, Magaziner J, Colón-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S. Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med. 2010;152:380–390.

    Article  PubMed  Google Scholar 

  11. Howell SJ, Sear YM, Yeates D, Goldacre M, Sear JW, Foex P. Risk factors for cardiovascular death after elective surgery under general anaesthesia. Br J Anaesth. 1998;80:14–19.

    Article  PubMed  CAS  Google Scholar 

  12. Jafari SM, Huang R, Joshi A, Parvizi J, Hozack WJ. Renal impairment following total joint arthroplasty: who is at risk? J Arthroplasty. 2010;25(6 suppl):49–53.

    Article  PubMed  Google Scholar 

  13. Jones DR, Lee HT. Surgery in the patient with renal dysfunction. Anesthesiol Clin. 2009;27:739–749.

    Article  PubMed  CAS  Google Scholar 

  14. Kellerman PS. Perioperative care of the renal patient. Arch Intern Med. 1994;154:1674–1688.

    Article  PubMed  CAS  Google Scholar 

  15. Kheterpal S, Tremper KK, Englesbe MJ, O’Reilly M, Shanks AM, Fetterman DM, Rosenberg AL, Swartz RD. Predictors of postoperative acute renal failure after noncardiac surgery in patients with previously normal renal function. Anesthesiology. 2007;107:892–902.

    Article  PubMed  Google Scholar 

  16. Klein DM, Tornetta P 3rd, Barbera C, Neuman D. Operative treatment of hip fractures in patients with renal failure. Clin Orthop Relat Res. 1998;350:174–178.

    Article  PubMed  Google Scholar 

  17. Lane N, Allen K. Hyponatraemia after orthopaedic surgery. BMJ. 1999;318:1363–1364.

    Article  PubMed  CAS  Google Scholar 

  18. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, De Zeeuw D, Hostetter TH, Lameire N, Eknoyan G. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005;67:2089–2100.

    Article  PubMed  Google Scholar 

  19. Lewis JR, Hassan SK, Wenn RT, Moran CG. Mortality and serum urea and electrolytes on admission for hip fracture patients. Injury. 2006;37:698–704.

    Article  PubMed  CAS  Google Scholar 

  20. Mehta RL, Chertow GM. Acute renal failure definitions and classification: time for change? J Am Soc Nephrol. 2003;14:2178–2187.

    Article  PubMed  Google Scholar 

  21. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A; Acute Kidney Injury Network. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:R31.

    Article  PubMed  Google Scholar 

  22. Molitoris BA, Levin A, Warnock DG, Joannidis M, Mehta RL, Kellum JA, Ronco C, Shah S; Acute Kidney Injury Network. Improving outcomes from acute kidney injury. J Am Soc Nephrol. 2007;18:1992–1994.

    Article  PubMed  CAS  Google Scholar 

  23. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 suppl 1):S1–S266.

    Google Scholar 

  24. Nickolas TL, Leonard MB, Shane E. Chronic kidney disease and bone fracture: a growing concern. Kidney Int. 2008;74:721–731.

    Article  PubMed  Google Scholar 

  25. Novis BK, Roizen MF, Aronson S, Thisted RA. Association of preoperative risk factors with postoperative acute renal failure. Anesth Analg. 1994;78:143–149.

    Article  PubMed  CAS  Google Scholar 

  26. Paul A, John B, Pawar B, Sadiq S. Renal profile in patients with orthopaedic trauma: a prospective study. Acta Orthop Belg. 2009;75:528–532.

    PubMed  Google Scholar 

  27. Roche JJ, Wenn RT, Sahota O, Moran CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ. 2005;331:1374.

    Article  PubMed  CAS  Google Scholar 

  28. Sinclair S, James S, Singer M. Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. BMJ. 1997;315:909–912.

    Article  PubMed  CAS  Google Scholar 

  29. Singh Mangat K, Mehra A, Yunas I, Nightingale P, Porter K. Is estimated peri-operative glomerular filtration rate associated with post-operative mortality in fractured neck of femur patients? Injury. 2008;39:1141–1146.

    Article  PubMed  Google Scholar 

  30. Thomas DR, Tariq SH, Makhdomm S, Haddad R, Moinuddin A. Physician misdiagnosis of dehydration in older adults. J Am Med Dir Assoc. 2003;4:251–254.

    Article  PubMed  Google Scholar 

  31. Venn R, Steele A, Richardson P, Poloniecki J, Grounds M, Newman P. Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures. Br J Anaesth. 2002;88:65–71.

    Article  PubMed  CAS  Google Scholar 

  32. Vivanti A, Harvey K, Ash S, Battistutta D. Clinical assessment of dehydration in older people admitted to hospital: what are the strongest indicators? Arch Gerontol Geriatr. 2008;47:340–355.

    Article  PubMed  Google Scholar 

  33. Weldon BC, Monk TG. The patient at risk for acute renal failure. Recognition, prevention, and preoperative optimization. Anesthesiol Clin North America. 2000;18:705–717.

    Article  PubMed  CAS  Google Scholar 

  34. White SM, Rashid N, Chakladar A. An analysis of renal dysfunction in 1511 patients with fractured neck of femur: the implications for peri-operative analgesia. Anaesthesia. 2009;64:1061–1065.

    Article  PubMed  CAS  Google Scholar 

  35. Wilson J, Woods I, Fawcett J, Whall R, Dibb W, Morris C, McManus E. Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery. BMJ. 1999;318:1099–1103.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors gratefully acknowledge Antonios Galanos PhD for his statistical advice and Samantha Stokes BSc (University College London, London, UK) for syntax and grammar consultation.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to George A. Macheras MD, PhD.

Additional information

Each author certifies that he or she, or a member of his or her immediate family, has no funding or commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request.

Clinical Orthopaedics and Related Research neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDA approval status, of any drug or device before clinical use.

Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.

This work was performed at KAT Hospital, Athens, Hellas.

About this article

Cite this article

Macheras, G.A., Kateros, K., Koutsostathis, S.D. et al. Which Patients Are at Risk for Kidney Dysfunction After Hip Fracture Surgery?. Clin Orthop Relat Res 471, 3795–3802 (2013). https://doi.org/10.1007/s11999-013-3098-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11999-013-3098-0

Keywords

Navigation