Abstract
We could not have predicted that HIV/AIDS would become one of our greatest public health challenges worldwide when the first cases were identified in the 1980s. More than 22 million people have died from the disease, and HIV is now the seventh-leading cause of death in the United States among 15- to 24-year-olds. At the beginning of this pandemic, most HIV infections of youth were acquired congenitally. Prenatal screening of pregnant women, early detection, and antiretroviral therapies have reduced mother-to-child transmission. Children born with HIV infections are now young adults living with HIV, while other adolescents are acquiring HIV primarily through high-risk behaviors. Associations between psychiatric symptoms and poor health outcomes have been recognized among adults. Few studies have examined these factors among youth. We review what is known about psychiatric syndromes among HIV-positive youth, and their treatments.
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Centers for Disease Control and Prevention (CDC): HIV prevalence estimates—United States, 2006. MMWR Morb Mortal Wkly Rep 2008; 57:1073–1076.
Hall HI, Song R, Rhodes P, et al.: Estimation of HIV incidence in the United States. JAMA 2008, 300:520–529.
UNAIDS 2004: 2004 report on the global AIDS epidemic. Available at http://www.unaids.org/bangkok2004/GAR2004_html/GAR2004_00_en.htm. Accessed December 12, 2009.
US Department of Health and Human Services, Centers for Disease Control and Prevention: HIV/AIDS Surveillance Report, 2005, vol 17, revised edition. Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention; 2007. Also available at http://www.cdc.gov/hiv/topics/surveillance/resources/reports/.
Donenberg G, Pao M: Youths and HIV/AIDS: psychiatry’s role in the changing epidemic. J Am Acad Child Adolesc Psychiatry 2005, 44:728–747.
Brown LK, Danokovsy MB, Lourie JK: Adolescents with psychiatric disorders and the risk of HIV. J Am Acad Child Adolesc Psychiatry 1997, 36:1609–1617.
Tubman JG, Gil AG, Wagner EF, Artigues H: Patterns of sexual risk behaviors and psychiatric disorders in a community sample of young adults. J Behav Med 2003, 26:473–500.
Gaughan DM, Hughes MD, Oleske JM, et al.; for the Pediatric AIDS Clinical Trials Group 219C Team: Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection. Pediatrics 2004, 113:e544–e551.
Scharko AM: DSM psychiatric disorders in the context of pediatric HIV/AIDS. AIDS Care 2006, 18:441–445.
•• Mellins CA, Brackis-Cott E, Leu CS, et al.: Rates and types of psychiatric disorders in perinatally human immunodeficiency virus-infected youth and seroreverters. J Child Psychol Psychiatry 2009, 50:1131–1138. This is the only well-designed and controlled study examining psychiatric disorders among youth with vertically acquired HIV disease.
Mellins CA, Smith R, O’Driscoll P, et al.: High rates of behavioral problems in perinatally HIV-infected children are not linked to HIV disease. Pediatrics 2003, 111:384–393.
Misdrahi D, Vila G, Funk-Brentano I, et al.: DSV-IV mental disorders and neurological complications in children and adolescents with human immunodeficiency virus type 1 infection (HIV-1). Eur Psychiatry 2004, 19:182–184.
Pao M, Lyon M, D’Angelo LJ, et al.: Psychiatric diagnosis in adolescents seropositive for the human immunodeficiency virus. Arch Pediatr Adolesc Med 2000, 154:240–244.
Lewinsohn PM, Hops H, Roberts RE, et al.: Adolescent psychopathology I: prevalence and incidence of depression and other DSM-IIIR disorders in high school students. J Abnorm Psychol 1993, 102:133–144. (Published erratum appears in J Abnorm Psychol 1993, 102:517.)
Wood SM, Shah SS, Steenhoff AP, Rutstein RM: The impact of AIDS diagnoses on long-term neurocognitive and psychiatric outcomes of surviving adolescents with perinatally acquired HIV. AIDS 2009, 23:1859–1865.
Evans DL, Charney DS, Lewis L, et al.: Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry 2005, 58:175–189.
Thompson A, Silverman B, Dzeng L, Treisman G: Psychotropic medications and HIV/AIDS. Clin Infect Dis 2006, 42:1305–1310.
• Pao M, Weiner L: Childhood and adolescence. In Textbook of AIDS Psychiatry. Edited by Cohen M, Gorman J. New York: Oxford University Press; 2009:307–336. This is an excellent review of what is known about HIV/AIDS in both congenitally and behaviorally acquired HIV disease.
Emslie GJ, Rush J, Weinberg WA, et al.: A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Arch Gen Psychiatry 1997, 54:1031–1037.
Geller B, Reising D, Leonard HL, et al.: Critical review of tricyclic antidepressant use in children and adolescents. J Am Acad Child Adolesc Psychiatry 1999, 38:513–516.
Rosenstein DR, Pao M, Cai J: Psychopharmacologic management in oncology. In Bethesda Handbook of Clinical Oncology, edn 2. Edited by Abraham J, Allegra CJ, Gulley J. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:521–528.
Geller B, Zimmerman B, Williams M: Phenomenology of prepubertal and early adolescent bipolar disorder: examples of elated mood, grandiose behaviors, decreased need for sleep, racing thoughts and hypersexuality. J Child Adolesc Psychopharmacol 2002, 12:3–9.
Kowatch RA, DelBello MP: Pediatric bipolar disorder: emerging diagnostic and treatment approaches. Child Adolesc Psychiatr Clin N Am 2006, 15:73–108.
Fernandez F, Levy JK, Samley HR, et al.: Effects of methylphenidate in HIV-related depression: a comparative trial with desipramine. Int J Psychiatry Med 1995, 25:53–67.
Seidel L, Walkup JT: Selective serotonin reuptake inhibitor use in the treatment of pediatric non–obsessive-compulsive disorder anxiety disorders. J Child Adolesc Psychopharmacol 2006, 16:171–179.
Havens JF, Mellins CA: Psychiatric aspects of HIV/AIDS in childhood and adolescence. In Child and Adolescent Psychiatry, edn 5. Edited by Rutter M, Taylor E. Oxford,: Blackwell; 2008:600–615.
Stuber M, Shemesh E, Saxe GN: Post-traumatic stress and responses in children with life-threatening illnesses. Child Adolesc Psychiatr Clin N Am 2003, 12:195–209.
Radcliffe J, Fleisher CL, Hawkins LA, et al.: Posttraumatic stress and trauma history in adolescents and young adults with HIV. AIDS Patient Care STDS 2007, 21:501–508.
Cohen J, Berliner L, March JS: Treatment of children and adolescents. In Effective Treatments for PTSD: Practice Guidelines From the International Society for Traumatic Stress Studies. Edited by Foa EB, Keane TM, Friedman MJ. New York: Guilford Press; 2000:330–332.
Turkel SB, Tavaré CJ: Delirium in children and adolescents. J Neuropsychiatry Clin Neurosci 2003, 15:431–435.
Scharko AM, Baker EH, Kothari P, et al.: Case study: delirium in an adolescent girl with human immunodeficiency virus-associated dementia. J Am Acad Child Adolesc Psychiatry 2006, 45:104–108.
McArthur JC: HIV dementia: an evolving disease. J Neuroimmunol 2004, 157:3–10.
Belman A: HIV-1 associated CNS disease in infants and children. In Research Publications: Association for Research in Nervous and Mental Disease. Edited by Price R, Perry S III. New York: Raven Press; 1994:289–310.
Carrico AW, Antoni MH: Effects of psychological interventions on neuroendocrine hormone regulation and immune status in HIV-positive persons: a review of randomized controlled trials. Psychosom Med 2008, 70:575–584.
Rotheram-Borus MJ, Murphy DA, Wight RG, et al.: Improving the quality of life among young people living with HIV. Eval Program Plann 2001, 24:227–237.
Brown LK, Schultz JR, Parsons JT, et al.: Sexual behavior change among human immunodeficiency virus-infected adolescents with hemophilia. Adolescent Hemophilia Behavioral Intervention Evaluation Project Study Group. Pediatrics 2000, 106:E22.
Murphy DA: Longitudinal antiretroviral adherence among adolescents infected with human immunodeficiency virus. Arch Pediatr Adolesc Med 2005, 159:764–770.
Williams PL: Predictors of adherence to antiretroviral medications in children and adolescents with HIV infection. Pediatrics 2006, 118:e1745–e1757.
Brown LK, Whiteley LB, Peters AA: HIV and AIDS. In Textbook of Child and Adolescent Psychiatry. Edited by Dulcan MK. Washington DC: American Psychiatric Publishing; 2010:495–508.
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Benton, T.D. Treatment of Psychiatric Disorders in Children and Adolescents with HIV/AIDS. Curr Psychiatry Rep 12, 104–110 (2010). https://doi.org/10.1007/s11920-010-0092-z
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DOI: https://doi.org/10.1007/s11920-010-0092-z