Skip to main content
SpringerLink
Log in

The Role of Temozolomide in Elderly Patients with Glioblastoma

  • Clinical Trial Report
  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Stupp R, Mason WP, van den Bent MJ, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987–996.

    Article  CAS  PubMed  Google Scholar 

  2. Keime-Guibert F, Chinot O, Taillandier L, et al.: Radiotherapy for glioblastoma in the elderly. N Engl J Med 2007, 356:1527–1535.

    Article  CAS  PubMed  Google Scholar 

  3. Hegi ME, Diserens AC, Gorlia T, et al.: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005, 352:997–1003.

    Article  CAS  PubMed  Google Scholar 

  4. Brandes AA, Vastola F, Basso U, et al.: A prospective study on glioblastoma in the elderly. Cancer 2003, 97:657–662.

    Article  PubMed  Google Scholar 

  5. Combs SE, Wagner J, Bischof M, et al.: Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients. Int J Radiat Oncol Biol Phys 2008, 70:987–992.

    PubMed  Google Scholar 

  6. Minniti G, De Sanctis V, Muni R, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol 2008, 88:97–103.

    Article  CAS  PubMed  Google Scholar 

  7. Sijben AE, McIntyre JB, Roldan GB, et al.: Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme. J Neurooncol 2008, 89:97–103.

    Article  PubMed  Google Scholar 

  8. Batchelor TT, Betensky RA, Esposito JM, et al.: Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res 2004, 10:228–233.

    Article  CAS  PubMed  Google Scholar 

  9. Jaeckle KA, Eyre HJ, Townsend JJ, et al.: Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study. J Clin Oncol 1998, 16:3310–3315.

    CAS  PubMed  Google Scholar 

Download references

Disclosure

No potential conflict of interest relevant to this article was reported.

Author information

Authors and Affiliations

  1. Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Lauren E. Abrey

Authors
  1. Lauren E. Abrey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lauren E. Abrey.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abrey, L.E. The Role of Temozolomide in Elderly Patients with Glioblastoma. Curr Neurol Neurosci Rep 10, 155–157 (2010). https://doi.org/10.1007/s11910-010-0106-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11910-010-0106-6

Keywords

Search

Navigation