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A New Era of Fibers in the Prevention of Colorectal Cancer

  • Published:
Current Colorectal Cancer Reports

Abstract

Several studies have indicated a role for diet in the etiology of colorectal cancer. Dietary fibers are a heterogeneous group of compounds consisting of the remnants of plant cells resistant to hydrolysis by human alimentary enzymes which were suggested to play a role in colorectal cancer prevention. While different observational and prospective cohort studies in the 1980s and ‘90s suggested a protective role for dietary fibers, most of the recent meta-analyses and large studies do not support this notion. New approaches such as identifying food patterns, identifying specific chemical compounds in the food, and studying differences in food processing may help in identifying such a role. Other new approaches include studying the immunologic properties of fibers and the effect of gut microbiota, which is affected by the content of fibers in the diet.

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References

Papers of particular interests, published recently, have been highlighted as follows: •Of importance ••Of major importance

  1. Giovannucci E, Wu K: Cancers of the colon and rectum. In: Schottenfeld D, Frau meni JF Jr (eds) Cancer epidemiology and prevention. 3rd edition. Oxford University Press. New York, pp 809–829.

  2. World Cancer Research Fund/American Institute for cancer Research. Food, nutrition, physical activity and the prevention of cancer: a global prospective. American Institute for Cancer Research, Washington, DC 2007.

  3. Hu FB: Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 2002, 13:3–9.

    Article  CAS  PubMed  Google Scholar 

  4. Marteau P, Flourie B: Tolerance to low-digestible carbohydrates: Symptomatology and methods. Br J Nutr 2001, 85: s17–s21.

    Article  CAS  PubMed  Google Scholar 

  5. IOM. Dietary Reference Intakes: Proposed definitions of dietary fibers. National Academy of Sciences, Washington, D.C.

  6. Weickert MO, Pfeiffer AF: Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr 2008, 138:439–442.

    CAS  PubMed  Google Scholar 

  7. AGA Technical Review: Impact of dietary fiber on colon cancer occurrence. Gastroenterology 2000;118:1235–1257

    Article  Google Scholar 

  8. Burkitt DP: Epidemiology of cancer of colon and rectum. Cancer 1971; 28: 3–13.

    Article  CAS  PubMed  Google Scholar 

  9. McKeown-Eyssen GE, Bright-See E: Dietary factors in colon cancer: international relationships. An update. Nutr Cancer 1985;7: 251–253.

    Article  CAS  PubMed  Google Scholar 

  10. • Kok-Yang T, Seow-Choen F: Fiber and colorectal diseases: separating fact from fiction. World J Gastroenterol 2007,13:4161–4167. This is a comprehensive summary on fibers and colonic diseases.

    Google Scholar 

  11. Park Y, Hunter DJ, Spiegelman D, et al.: Dietary fiber intake and risk of colorectal cancer, a pooled analysis of prospective cohort studies. JAMA 2005, 294:2849–2857.

    Article  CAS  PubMed  Google Scholar 

  12. Boffetta P, Couto E, Wichmann J, et al.: Fruit and vegetables intake and overall cancer risk in the European prospective investigation into cancer and nutrition (EPIC). J Natl Cancer INST 2010,102: 529–537.

    Article  CAS  PubMed  Google Scholar 

  13. Uchida K, Kono S, Toyomura YG, et al.: Dietary fiber, source foods And colorectal cancer risk: the Fukuoka colorectal cancer study. Scand J Gastroenterol 2010, 45:1223–1231.

    Article  CAS  PubMed  Google Scholar 

  14. Trock B, Lanza E, Greenwald P: Dietary fiber, vegetables and colon cancer: critical review and meta-analyses of the epidemiologic evidence. J Natl Cancer Inst 1990, 82: 650–661.

    Article  CAS  PubMed  Google Scholar 

  15. Friedenreich CM, Brant RF, Riboli E: Influence of methodological factors in a pooled analysis of 13 case-control studies of colorectal cancer and dietary fibers. Epidemiology 1994, 5: 66–79.

    Article  CAS  PubMed  Google Scholar 

  16. Assano T, Mcleod RS: Dietary fibers for the prevention of colorectal adenomas and carcinomas. Cochrane Database Syst Rev 2002 CD003430.

  17. Ishikawa H, Akedo I, Otani T, et al.: Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors. Int J Cancer 2005, 116: 762–767.

    Article  CAS  PubMed  Google Scholar 

  18. Jacobs ET, Lanza E, Alberts DS, et al.: Fiber, sex, and colorectal adenoma: results of a pooled analysis. Am J Clin Nutr 2006, 83:343–349.

    CAS  PubMed  Google Scholar 

  19. Flood A, Rastogi T, Wirfalt E, et al.: Dietary patterns as identified by factor analysis and colorectal cancer among middle-aged Americans. Am J Clin Nutr 2008 2008,88:176–184.

    CAS  PubMed  Google Scholar 

  20. Williams CD, Satia JA, Adair LS, et al.: Dietary patterns, food groups and rectal cancer risk in Whites and African-Americans. Cancer Epidemiol Biomarkers Prev 2009, 18:1552–1561.

    Article  CAS  PubMed  Google Scholar 

  21. Bravi F, Edefonti V, Bosetti C, et al.: Nutrient dietary patterns and risk of colorectal cancer: a case-control study from Italy. Cancer Causes Control 2010, Aug 1. [Epub ahead of print]

  22. • Randi G, Edefonti V, Ferraroni M, et al.: Dietary patterns and risk of colorectal cancer and adenomas. Nutrition Reviews 2010, 68:389–408. This is a literature review on the different nutritional methods of evaluation in the area of colorectal cancer.

    Article  PubMed  Google Scholar 

  23. Egeberg R, Olsen A, Loft S, et al.: Intake of wholegrain products and risk of colorectal cancers in the diet, cancer and health cohort study. Br J Cancer 2010, 103:730–734.

    Article  CAS  PubMed  Google Scholar 

  24. Schatzkin A, Mouw T, Park Y, et al.: Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am J Clin Nutr 2007, 85:1353–1360.

    CAS  PubMed  Google Scholar 

  25. Fuller Z, Louis P, Mihajlovski A, et al.: Influence of cabbage processing methods and prebiotic manipulation of coloniuc microflora on glucosinolate breakdown in man. Br J Nutr 2007, 98:364–372.

    Article  CAS  PubMed  Google Scholar 

  26. •• Wismar R, Brix S, Frokiaer H, Laerke HN: Dietary fibers as immunoregulatory compounds in health and disease. Ann N.Y. Acad. Sci 2010, 1190:70–85. This is the most updated review on dietary fibers and gut immunoregulation.

    Article  CAS  PubMed  Google Scholar 

  27. Chan GC-F, Chan WK, Sze DM-Y: The effect of β glucan on human immune and cancer cells. J Hematol & Oncology 2009, 2: 25–36.

    Article  Google Scholar 

  28. • Davis CD, Milner JA: Gastrointestinal microflora, food components and colon cancer prevention. J of Nutritional Biochemistry 2009, 20:743–752. This is a recent review on food components and colon cancer risks.

    Article  CAS  Google Scholar 

  29. Manning TS, Gibson GR: Microbial-gut interactions in health and disease. Best Pract Res Clin Gastroenterol 2004, 18: 287–298.

    Article  PubMed  Google Scholar 

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Correspondence to Nachum Vaisman.

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Vaisman, N. A New Era of Fibers in the Prevention of Colorectal Cancer. Curr Colorectal Cancer Rep 7, 58–61 (2011). https://doi.org/10.1007/s11888-010-0072-z

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