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Operative Microwave Ablation for Hepatocellular Carcinoma: Complications, Recurrence, and Long-Term Outcomes

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Treatment of hepatocellular carcinoma (HCC) in the setting of cirrhosis is limited by tumor size/location and underlying liver disease. Radiofrequency ablation is utilized in selected patients; however, local recurrence remains a concern. Microwave ablation (MWA) delivers energy to tissue in a unique fashion, reducing local recurrence. A minimally invasive operative approach allows for mobilization/protection of adjacent structures, intra-operative ultrasound, and assessment of ablation progress.

Study Design

Retrospective review of operative MWA performed for HCC in patients with cirrhosis over a 4-year period at a single center. Complications were stratified by Clavien–Dindo classification. Incomplete ablation and local, regional, and metastatic recurrence was assessed on follow-up imaging. Survival was assessed in months.

Results

Fifty-four patients with 73 tumors underwent MWA. Median tumor size was 2.6 cm (range 0.5–8.5 cm). Cirrhosis was present in 92.6 % of patients, with a Child–Pugh score of B/C in 27.8 % and hepatitis C present in 59.3 %. A minimally invasive approach was used in 94.5 % of patients. There were no deaths within 30 days. Thirty-day morbidity was 28.9 %, with grade III complications present in 11.5 %. Delayed complications occurred in 7.8 % of patients, with a 5.6 % 90-day mortality. Incomplete ablation was identified in 5.9 % of tumors with local recurrence of 2.9 % at 9 months median follow-up. Regional and metastatic recurrence occurred in 27.5 and 11.8 % at 9 months median follow-up. Median survival was not reached at 11 months median follow-up. One- and 2-year survival was 72.3 and 58.8 %.

Conclusion

Operative, preferably minimally invasive, MWA can be performed in cirrhotic patients with HCC with acceptable morbidity and low recurrence rates. High regional and metastatic recurrence rates in these patients underscore the need for minimally invasive, low morbidity approaches to liver-directed therapy.

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Abbreviations

MWA:

Microwave ablation

HCC:

Hepatocellular carcinoma

RFA:

Radiofrequency ablation

CT:

Computed tomography

US:

Ultrasound

IOUS:

Intra-operative ultrasound

MRI:

Magnetic resonance imaging

AFP:

alpha-Fetoprotein

MELD:

Model for End-Stage Liver Disease

AJCC:

American Joint Committee on Cancer

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Authors and Affiliations

  1. Hepato-Pancreato-Biliary Surgery, Department of General Surgery, Carolinas Medical Center, 1025 Morehead Medical Drive, Suite 300, Charlotte, NC, 28204, USA

    Ryan Z. Swan, David Sindram, John B. Martinie & David A. Iannitti

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  1. Ryan Z. Swan
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  2. David Sindram
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  3. John B. Martinie
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  4. David A. Iannitti
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Correspondence to David A. Iannitti.

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RZS and DS contributed equally as first author for this work.

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Swan, R.Z., Sindram, D., Martinie, J.B. et al. Operative Microwave Ablation for Hepatocellular Carcinoma: Complications, Recurrence, and Long-Term Outcomes. J Gastrointest Surg 17, 719–729 (2013). https://doi.org/10.1007/s11605-013-2164-y

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