Abstract
Introduction
We retrospectively evaluated the efficacy of three-dimensional conformal radiotherapy (3D-CRT) for spinal schwannoma.
Methods
Nine patients with spinal schwannoma were treated with 3D-CRT. All patients had a paravertebral or intraosseous component. Tumor sizes ranged from 0.8 to 8.7 cm, with a median of 3.5 cm. The prescribed dose was 50 Gy in 25 fractions at the isocenter, except for 1 patient who received 66 Gy in 33 fractions for a large sacral tumor. The follow-up period ranged from 20 to 137 months, with a median of 72 months.
Results
Tumor shrinkage within 3 mm occurred in 4 patients and tumor expansion within 3 mm occurred in 3. One tumor showed neither expansion nor shrinkage at the last follow-up. One patient experienced transient expansion by 8 mm in diameter at 12 months after the completion of radiotherapy (35–43 mm), and then the tumor size remained unchanged for 7 years. No severe late toxicity ≥ grade 3 was observed.
Conclusions
Only 1 of 9 tumors showed transit expansion over 3 mm after 3D-CRT, and severe late radiation toxicity was not observed. Use of 3D-CRT should be considered a treatment option for spinal schwannoma.
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This work was supported in part by a Grant-in-Aid for Science Research from the Ministry of Education, Science, Sports and Culture, Japan.
Ethical statement
The Institutional Review Board at Hokkaido University Hospital approved this retrospective study in December 2012.
Conflict of interest
Hiroki Shirato received research findings from Shimadzu Corp., Hitachi Medico, and Hitachi Co., Ltd.
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Onimaru, R., Hida, K., Takeda, N. et al. Three-dimensional conformal fractionated radiotherapy for spinal schwannoma with a paravertebral or an intraosseous component. Jpn J Radiol 33, 757–763 (2015). https://doi.org/10.1007/s11604-015-0492-4
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DOI: https://doi.org/10.1007/s11604-015-0492-4