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Effects of three weight reduction methods on serum leptin and metabolic parameters in obese females

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Abstract

Background

It is controversial about the best method of weight reduction for health benefits. The purpose of this study was to determine leptin and some coronary heart disease risk factor responses in young females after aerobic and resistance exercise training and low caloric diet.

Methods

Thirty-six inactive obese girls volunteered to participate in the study. They were divided to four equal aerobic training, resistance training, low caloric diet and control groups. Fast blood samples were collected at baseline, after 4 and 8 weeks. Exercise groups had 8-week programs, three sessions aerobic (60 min cycling at 60–70 % of Vo2max) or resistance (12 exercises, 4 sets, 15 repetitions, 60 % of 1RM) training per week.

Results

Significant decrease was observed in low caloric diet group from pre-test to 4 and 8 weeks (p < 0.05), but there was no significant difference in serum leptin, within other groups (p > 0.05). There was a significant difference between low caloric diet and control group in serum leptin from pre-test to post-test (p < 0.05). No significant differences (p > 0.05) were observed between groups on serum insulin, low-density lipoprotein, high-density lipoprotein, total cholesterol, and glucose at any trails. Significant decrease in glucose was observed within diet group from pre- to 4- and 8-week test (p < 0.05).

Conclusion

Main finding of this study is that 8 weeks aerobic and resistance training was not sufficient to produce favorite changes on serum leptin and metabolic parameters. It seems that low caloric diet may reduce serum leptin.

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References

  1. Tam J, Fukumura D, Jain RK (2010) A mathematical model of murine metabolic regulation by leptin: energy balance and defence of a stable body weight. Cell Metab 9(1):52–63

    Article  Google Scholar 

  2. Ren J (2004) Leptin and hyperleptinemia—from friend to foe for cardiovascular function. J Endocrinol 181:1–10

    Article  PubMed  CAS  Google Scholar 

  3. Rahmouni K, Haynes WG (2004) Leptin and the cardiovascular system. Resent Prog Horm Res 59:224–244

    Google Scholar 

  4. Rabe K, Lehrke M, Parhofer KG, Broedl UC (2008) Adipokines and insulin resistance. Mol Med 14:741–751

    Article  PubMed  CAS  Google Scholar 

  5. Konstantinides S, Schafer K, Koschnick S, Loskutoff DJ (2001) Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108:1533–1540

    PubMed  CAS  Google Scholar 

  6. Rahmani-Nia F, Rahnama N, Hojjati Z, Soltani B (2008) Acute effects of aerobic and resistance exercise on serum leptin and some risk factors of coronary heart disease in obese females. Sport Sci Health 3:118–124

    Article  Google Scholar 

  7. Altman R (2003) Risk factors in coronary atherosclerosis athero-inflammation: the meeting point. Thromb J 1:4–7

    Article  PubMed  Google Scholar 

  8. Singhal A, Farooqi IS, Cole TJ, O’Rahilly S, Fewtrell M, Kattenhorn M, Lucas A, Deanfield J (2002) Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease. Circulatin 106:1919–1926

    Article  CAS  Google Scholar 

  9. Dardeno TA, Chou SH, Moon HS, Chamberland JP, Fiorenza CG, Mantzoros CS (2010) Leptin in human physiology and therapeutics. Front Neuroendocrinol 31(3):377–393

    Article  PubMed  CAS  Google Scholar 

  10. Jurimae J, Jurimae T (2005) Leptin responses to short term exercise in college level male rowers. Br J Sports Med 39:6–9

    Article  PubMed  CAS  Google Scholar 

  11. McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chernishof M, Gorn A, Witztum JL, Wong WK, Weisman M, Wallace DJ, La Cava A, Hahn BH (2011) High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis 70(9):1619–1624

    Article  PubMed  CAS  Google Scholar 

  12. Frank LL, Sorensen BE, Yasui Y, Tworoger SS, Schwartz RS, Ulrich CM, Irwin ML, Rudolph RE, Rajan KB, Stanczyk F, Bowen D, Weigle DS, Potter JD, McTiernan A (2005) Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial. Obes Res 13:615–625

    Article  PubMed  Google Scholar 

  13. Webber J (2003) Energy balance in obesity. Proc Nutr Soc 62:539–543

    Article  PubMed  Google Scholar 

  14. Kyriazis GA, Caplan JD, Lowndes J, Carpenter RL, Dennis KE, Sivo SA, Angelopoulos TJ (2007) Moderate exercise-induced energy expenditure does not alter leptin levels in sedentary obese men. Clin J Sport Med 17:49–51

    Article  PubMed  Google Scholar 

  15. Reseland JE, Andessen SA, Solvoll K, Hjermann I, Urdal P, Holme I, Drevon CA (2001) Effect of long-term change in diet and exercise on plasma leptin concentration. Clin Nutr 73:240–245

    CAS  Google Scholar 

  16. Boden G, Chen X, Mozzoli M, Ryan I (1996) Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 81:3419–3423

    Article  PubMed  CAS  Google Scholar 

  17. Thong FSL, Hudson R, Ross R, Janssen I, Grahan TE (2000) Plasma leptin in moderately obese males: independent effects of weight loss and aerobic exercise. Am J Physiol Endocrinol Metab 279:E307–E313

    PubMed  CAS  Google Scholar 

  18. Kraemer KK, Chu H, Castracane VD (2002) Leptin and exercise. Exp Biol Med 227:701–708

    CAS  Google Scholar 

  19. Rahmani-Nia F, Hojjati Z, Rahnama N, Soltani B (2009) Leptin, heart disease and exercise. World J Sport Sci 1:13–20

    Google Scholar 

  20. Pasman WJ, Westerterp-Plantegna MS, Saris WHM (1998) The effect of exercise training on plasma leptin levels in obese male. Am J Physiol 274:E280–E286

    PubMed  CAS  Google Scholar 

  21. Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, Manousaki M, Douroudos I, Taxildaris K, Mitrakou A (2005) Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 90:5970–5977

    Article  PubMed  CAS  Google Scholar 

  22. Fatouros IG, Chatzinikolaou A, Tournis S, Nikolaidis MG, Jamurtas AZ, Douroudos II, Papassotiriou I, Thomakos PM, Taxildaris K, Mastorakos G, Mitrakou A (2009) Intensity of resistance exercise determines adipokine and resting energy expenditure responses in overweight elderly individuals. Diabetes Care 32(12):2161–2167

    Article  PubMed  CAS  Google Scholar 

  23. Wisse BE (2004) The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 15:2792–2800

    Article  PubMed  CAS  Google Scholar 

  24. Li MD (2011) Leptin and beyond: an odyssey to the central control of body weight. Yale J Biol Med 84(1):1–7

    PubMed  CAS  Google Scholar 

  25. Askari H, Tykodi G, Liu J, Dagogo-Jack S (2010) Fasting plasma leptin level is a surrogate measure of insulin sensitivity. J Clin Endocrinol Metab 95(8):3836–3843

    Article  PubMed  CAS  Google Scholar 

  26. Hilton LK, Loucks AB (2000) Low energy availability, not exercise stress, suppress the durenal rhythm of leptin in healthy young women. Am J Physiol Endocrinol Metab 278:E43–E49

    PubMed  CAS  Google Scholar 

  27. Vega GL, Grundy SM (2013) Metabolic risk susceptibility in men is partially related to adiponectin/leptin ratio. J Obes 2013:409679

    Article  PubMed  Google Scholar 

  28. Gomez-Merino D, Chennaoui M, Drogou C, Bonneau D, Guezennec CY (2002) Decrease in serum leptin after prolonged physical activity in men. Med Sci Sports Exerc 34:1594–1599

    Article  PubMed  CAS  Google Scholar 

  29. Hall JE, Kuo JJ, da Silva AA, de Paula RB, Liu J, Tallam L (2003) Obesity-associated hypertension and kidney disease. Curr Opin Nephrol Hypertens 12:195–299

    Article  PubMed  CAS  Google Scholar 

  30. Bouassida A, Zalleg D, Bouassida S, Zaouali M, Feki Y, Zbidi A, Tabka Z (2006) Leptin, its implication in physical exercise and training: a short review. J Sport Sci Med 5:172–181

    Google Scholar 

  31. Kerksick CM, Wismann-Bunn J, Fogt D, Thomas AR, Taylor L, Campbell BI, Wilborn CD, Harvey T, Roberts MD, La Bounty P, Galbreath M, Marcello B, Rasmussen CJ, Kreider RB (2010) Changes in weight loss, body composition and cardiovascular disease risk after altering macronutrient distributions during a regular exercise program in obese women. Nutr J 9:59

    Article  PubMed  Google Scholar 

  32. Fenkci S, Sarsan A, Rota S, Ardic F (2006) Effects of resistance or aerobic exercises on metabolic parameters in obese women who are not on a diet. Adv Ther 23:404–413

    Article  PubMed  CAS  Google Scholar 

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  1. Islamic Azad University, Rasht Branch, Rasht, Iran

    Z. Hojjati

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  1. Z. Hojjati
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Correspondence to Z. Hojjati.

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Hojjati, Z. Effects of three weight reduction methods on serum leptin and metabolic parameters in obese females. Sport Sci Health 9, 113–119 (2013). https://doi.org/10.1007/s11332-013-0156-7

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  • DOI: https://doi.org/10.1007/s11332-013-0156-7

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