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Masitinib for the treatment of canine atopic dermatitis: a pilot study

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Abstract

There is an on-going need to identify medications suitable for the long-term treatment of canine atopic dermatitis (CAD). Masitinib mesilate is a potent and selective tyrosine kinase inhibitor of the c-KIT receptor. A strong relationship exists between the SCF/c-KIT pathway and pathogenesis of CAD, suggesting that masitinib may potentially fulfil the above role. This study reports on an uncontrolled pilot study of masitinib in CAD. Masitinib was administered orally to 11 dogs at a mean dose of 11.0 ± 1.83 mg/kg/day (free base) for 28 days. Treatment response was assessed by evolution of clinical appearance according to a modified version of the Canine Atopic Dermatitis Extent and Severity Index (mCADESI), pruritus scale and surface area of lesions. Masitinib improved CAD with a mean reduction in mCADESI of 50.7 ± 29.8% (95% C.I. = 29.4–72.0; p = 0.0004) at day 28 relative to baseline, with 8/10, 8/10 and 4/10 dogs showing improvement of ≥33%, ≥40% and ≥50%, respectively. Improvement was further evidenced by a decrease in pruritus score and the surface area of lesions. No serious or severe adverse events occurred during this trial, although 6/11 dogs presented with mild to moderate treatment related adverse events. There is sufficient compelling evidence to warrant further investigation.

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Abbreviations

AE:

Adverse event

CAD:

Canine atopic dermatitis

CsA:

Cyclosporin A

D0, D12, D28:

Baseline, Day-12, Day-28, respectively

FAK:

Focal adhesion kinase

FcεRI:

High-affinity receptor for Immunoglobulin E

FGFR3:

Fibroblast growth factor receptor 3

GC:

Glucorticoid steroids

IC50 :

Half inhibitory concentration

IgE:

Immunoglobulin E

Lyn:

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

mCADESI:

modified version of the Canine Atopic Dermatitis Extent and Severity Index

PDGFR:

Platelet-derived growth factor receptor

SAE:

Serious adverse event

SCF:

Stem cell factor

µM:

Micro molar

PDGFRα:

PDGFR alpha

PDGFRβ:

PDGFR beta

FcεRI:

Fc epsilon RI

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Authors and Affiliations

  1. Austin Veterinary Dermatology, Round Rock, TX, USA

    Jenise Daigle

  2. AB Science S.A., Paris, France

    Alain Moussy, Colin D. Mansfield & Olivier Hermine

  3. Service d’Hematologie, CNRS, UMR 8147, Centre de reference des mastocytoses, Université Paris V René Descartes, Hôpital Necker, 149—161 rue de Sèvres, 75743, Paris, France

    Olivier Hermine

Authors
  1. Jenise Daigle
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  2. Alain Moussy
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  3. Colin D. Mansfield
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  4. Olivier Hermine
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Correspondence to Olivier Hermine.

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AB Science, S.A., Paris, France

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Daigle, J., Moussy, A., Mansfield, C.D. et al. Masitinib for the treatment of canine atopic dermatitis: a pilot study. Vet Res Commun 34, 51–63 (2010). https://doi.org/10.1007/s11259-009-9332-2

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