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The new Asian modified CKD-EPI equation leads to more accurate GFR estimation in Chinese patients with CKD

  • Nephrology - Original Paper
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International Urology and Nephrology Aims and scope Submit manuscript

A Nephrology – Letter to the Editor to this article was published on 28 December 2016

Abstract

Objective

To verify whether the new Asian modified CKD-EPI equation improved the performance of original one in determining GFR in Chinese patients with CKD.

Method

A well-designed paired cohort was set up. Measured GFR (mGFR) was the result of 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) dual plasma sample clearance method. The estimated GFR (eGFR) was the result of the CKD-EPI equation (eGFR1) and the new Asian modified CKD-EPI equation (eGFR2). The comparisons were performed to evaluate the superiority of the eGFR2 in bias, accuracy, precision, concordance correlation coefficient and the slope of regression equation and measure agreement.

Results

A total of 195 patients were enrolled and analyzed. The new Asian modified CKD-EPI equation improved the performance of the original one in bias and accuracy. However, nearly identical performance was observed in the respect of precision, concordance correlation coefficient, slope of eGFR against mGFR and 95 % limit of agreement. In the subgroup of GFR < 60 mL min−1/1.73 m2, the bias of eGFR1 was less than eGFR2 but they have comparable precision and accuracy. In the subgroup of GFR > 60 mL min−1/1.73 m2, eGFR2 performed better than eGFR1 in terms of bias and accuracy.

Conclusion

The new Asian modified CKD-EPI equation can lead to more accurate GFR estimation in Chinese patients with CKD in general practice, especially in the higher GFR group.

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Author contributions

YQ Provided and used the software.PX and JMH conceived and designed the experiments. PX, JMH, ZF, LGW, PF and LPP performed the experiments. PX and JMH analyzed the data. PX, JMH and YQ contributed reagents/materials/analysis tools. PX and JMH Wrote the paper.

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Authors and Affiliations

  1. Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People’s Republic of China

    Peng Xie, Jian-min Huang, Fang Zhang, Ling-ge Wei, Peng Fu & Xiao-jie Huang

  2. Department of Research, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People’s Republic of China

    Yan Qu

  3. Department of Nephrology, Bethune International Peace Hospital, No. 398 of Zhongshan Western Road, Shijiazhuang, Hebei Province, People’s Republic of China

    Jinghua Wang

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  1. Jinghua Wang
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  2. Peng Xie
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  3. Jian-min Huang
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  4. Yan Qu
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Corresponding author

Correspondence to Peng Xie.

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Conflict of interest

The authors have declared that no competing interests exist.

Additional information

This paper was partially supported by training and basic fund of clinical medicine provided by Finance Department of Hebei Province (2016).

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Wang, J., Xie, P., Huang, Jm. et al. The new Asian modified CKD-EPI equation leads to more accurate GFR estimation in Chinese patients with CKD. Int Urol Nephrol 48, 2077–2081 (2016). https://doi.org/10.1007/s11255-016-1386-9

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