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Ocular fundus abnormalities in patients with Balkan endemic nephropathy and other chronic kidney diseases

  • Nephrology - Original article
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Abstract

Aim

The aim of this study was to examine the ocular fundus pathology in patients with Balkan endemic nephropathy (BN) and chronic kidney diseases (CKD).

Methods

The study included 51 patients with BN from the South Morava River region in Serbia, and 102 subjects with different stages of chronic renal diseases, matched according to age and gender, obtained from a database used in a recently published study. All patients had visited Outpatient Department of the Clinic of Nephrology, Clinical Center Nis. All patients underwent routine ophthalmic examinations.

Results

There were significantly more (P < 0.001) patients with age-related macular degeneration (AMD) in the group with BN (31.37 %) than in those with CKD (5.88 %). Multivariate logistic regression analysis confirmed that the significant factors related to AMD in the group with BN were albuminuria (P < 0.05) and proteinuria (P < 0.05); in CKD patients, the level of HDL (P < 0.05), while negative correlation with the level of triglyceride was registered (P < 0.05). There was no association between estimated glomerular filtration rate and AMD. The significant factors related to retinopathy in the group with BN are age (P < 0.05) and serum creatinine values (P < 0.05), in patients with CKD increasing age (P < 0.001) and DM (P < 0.05).

Conclusion

Ocular fundus pathology in patients with BN is similar to the pathology of other CKD, but with significantly more AMD (about four times), probably related to the genetic/epigenetic factors.

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Acknowledgments

This work was supported by a Grant No. 175092, from the Ministry of Education, Science and Technological Development of Serbia.

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Authors and Affiliations

  1. Clinic of Ophthalmology, Faculty of Medicine, University of Nis, Bul.Zorana Djindjica 81, 18000, Nis, Serbia

    Jasmina Djordjevic Jocic & Predrag Jovanovic

  2. Clinic of Nephrology, Faculty of Medicine, University of Nis, Nis, Serbia

    Rade Cukuranovic

  3. Faculty of Medicine, Institute of Biochemistry, University of Nis, Nis, Serbia

    Vidosava Djordjevic

  4. State University of Novi Pazar, Novi Pazar, Serbia

    Dragan Bogdanovic & Vladisav Stefanovic

  5. Faculty of Medicine, University of Nis, Nis, Serbia

    Marija Mihajlovic & Jovana Cukuranovic-Kokoris

  6. Research Department, Faculty of Medicine, University of Nis, Nis, Serbia

    Vladisav Stefanovic

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  1. Jasmina Djordjevic Jocic
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Correspondence to Jasmina Djordjevic Jocic.

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Djordjevic Jocic, J., Cukuranovic, R., Jovanovic, P. et al. Ocular fundus abnormalities in patients with Balkan endemic nephropathy and other chronic kidney diseases. Int Urol Nephrol 47, 1693–1701 (2015). https://doi.org/10.1007/s11255-015-1078-x

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  • DOI: https://doi.org/10.1007/s11255-015-1078-x

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