Abstract
Background
Extramammary Paget’s disease (EMPD) is considered an intraepithelial adenocarcinoma. Paget’s disease of the penis is the most common disease of EMPD in male patients.
Objective
The objective of this study was to investigate and improve our knowledge of the clinical features, diagnosis, therapeutic methods and outcome of penile Paget’s disease.
Materials and methods
Eleven patients from 2007 to 2012 with Paget’s disease of the penis were analyzed retrospectively based on diagnosis, treatment and the results on follow-up. All patients received local expanding resection with intraoperative frozen sections and reconstruction of defects with split-thickness skin graft from autologous thigh tissue.
Results
All surgeries were successful, and the postoperative course was uneventful with complete wound healing and graft survival. No lymph node metastasis was obtained. Both the morphology of the penis and its function were well maintained.
Conclusions
Chronic skin lesions of the penis should be biopsied as soon as possible, if they are suspected to be due to Paget’s disease. Paget’s disease of the penis should be treated with wide local excision and intraoperative frozen section examination. In addition, reconstruction of defects with split-thickness skin graft from the patient’s thigh is an ideal choice for treatment.
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The authors declare no conflict of interest.
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Xiao Yun Xu and Ning Shao contributed equally to the present work and each is considered first author.
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Xu, X.Y., Shao, N., Qiao, D. et al. Reconstruction of defects in 11 patients with penile Paget’s diseases with split-thickness skin graft. Int Urol Nephrol 45, 413–420 (2013). https://doi.org/10.1007/s11255-013-0396-0
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DOI: https://doi.org/10.1007/s11255-013-0396-0