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Angiotensin-converting enzyme I/D polymorphism and the risk of thoracic aortic dissection in Chinese Han population

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Abstract

Thoracic aortic dissection (TAD) is a catastrophic cardiovascular disease and is thought to have a genetic basis. Various studies have indicated that renin-angiotensin system plays an important role in the pathogenesis of aortic disease. To determine the association of the I/D polymorphism of ACE gene with the risk of TAD in a Chinese Han population, a hospital-based case–control study was designed consisting of 161 subjects with TAD and 256 control subjects. The genotype frequency of the ACE I/D polymorphism was determined by using a polymerase chain reaction assay. The overall distribution of ACE I/D genotypes was significantly different between the two groups. Compared with the controls, the frequency of DD genotypes and the D allele of ACE gene were significantly increased in TAD patients. Multivariate logistic regression adjusting for conventional vascular risk factors confirmed the association between the ACE I/D polymorphism and the susceptibility to TAD (OR 2.14, 95 % CI 1.38–3.32, P = 0.001). Our data demonstrated that the ACE I/D polymorphism appeared to be an important risk factor in the development of TAD. However, further validation in large population-based studies is needed to confirm the finding.

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Acknowledgments

The study was supported by the Natural Science Foundation of Liaoning Province (grant no. 20062078 and 201102237).

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Authors and Affiliations

  1. Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, 83 Wenhua Road, Shenyang, China

    Quanmin Jing, Xiaozeng Wang, Yingyan Ma, Ming Yang, Guiqi Huang, Xin Zhao & Yaling Han

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  1. Quanmin Jing
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  2. Xiaozeng Wang
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  3. Yingyan Ma
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  4. Ming Yang
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  6. Xin Zhao
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  7. Yaling Han
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Correspondence to Yaling Han.

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Jing, Q., Wang, X., Ma, Y. et al. Angiotensin-converting enzyme I/D polymorphism and the risk of thoracic aortic dissection in Chinese Han population. Mol Biol Rep 40, 1249–1254 (2013). https://doi.org/10.1007/s11033-012-2167-x

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  • DOI: https://doi.org/10.1007/s11033-012-2167-x

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