Abstract
Chondroitin 4-sulfate (C4S) is a bioactive glycosaminoglycan with inductive properties in bone and tissue regeneration. Dicalcium phosphate dehydrate cements (known as brushite) are biocompatible and resorbable materials used in bone and dental surgery. In this study we analyzed the effect of C4S on the setting of a calcium phosphate cement and the properties of the resulting material. Brushite based cement powder was synthesised by mixing monocalcium phosphate with β-tricalcium phosphate and sodium pyrophosphate. When the concentration of C4S, in the liquid added to the cement powder, was between 1 and 8% the cement final setting time increases. Furthermore, the cement diametral tensile strength remains unaffected when solutions with concentrations of C4S below 5% were used, but decreases at higher C4S concentrations. Calorimetric analysis showed that the cements prepared with C4S alone and in combination with silica gel have a greater content of hydrated water. We concluded from our study that the addition of small amounts of C4S increases the cement setting time without affecting its diametral tensile strength and at the same time improves the cement’s hydrophilicity.
Similar content being viewed by others
References
U. GBURECK, O. GROLMS, J. E. BARRALET, L. M. GROVER and R. THULL, Biomaterials 24(23) (2003) 4123
Y. YIN, F. YE, S. CAI, K. YAO, J. CUI and X. SONG, J. Mater. Sci. Mater. Med. 14 (2003) 255
M . BOHNER, U. GBURECK and J. E. BARRALET, Biomaterials 26(33) (2005) 6423
M. BOHNER, S. MATTER. pat (WO0141824 (2002–11–06)
M. YOSHIKAWA, S. HAYAMI and T. TODA, Mater. Sci. Eng: C. 20(1–2) (2002) 135
M. YOSHIKAWA and T. TODA, J. Eur. Ceram. Soc. 24(2) (2004) 521
H.Z. HEROLD and A. TADMOR, Isr. J. Med.Sci. 5(3) (1969) 425
M. MOSS, G. O. KRUGER and D. C. REYNOLDS, Oral Surg. Oral Med. Oral Pathol. 20(6) (1965) 795
R.A. SKINNER, P. D. TOTO and A. W. GARGIULO, J. Periodontol. 47(4) (1976) 196
B. AZAZ, D. GORDON and A. SHTEYER, Refuat Hapeh Vehashinayim 23 (1974) 75
X.H. ZOU, W. C. FOONG, T. CAO, B. H. BAY, H. W. OUYANG and G. W. YIP, J. Dent. Res. 83(11) (2004) 880
Y.J. PARK, Y. M. LEE, J. Y. LEE, Y. J. SEOL, C. P. CHUNG and S. J. LEE, J. Control Release 67(2–3) (2000) 385
D.S. KESKIN, A. TEZCANER, P. KORKUSUZ, F. KORKUSUZ and V. HASIRCI, Biomaterials 26(18) (2005) 4023
A. SCABBIA, L. TROMBELLI, J. Clin. Periodontol. 31(5) (2004) 348
C.M. SERRE, M. PAPILLARD, P. CHAVASSIEUX and G. BOIVIN, Biomaterials 14(2) (1993) 97
A. REBAUDI, P. SILVESTRINI and P. TRISI, Int. J. Periodontics Restorative Dent. 23(4) (2003) 371
N. VOLPI, Biomaterials 20(15) (1999) 1359
N. VOLPI, Biomaterials 23(14) (2002) 3015
SG REES, D. T. HUGHES WASSELL, R.J. WADDINGTON and G. EMBERY, Biochim. Biophys. Acta. 1568(2) (2001) 118
G. GAFNI, D. SEPTIERAND and M. GOLDBERG, J. Cryst. Growth 205(4) (1999) 618
M. P. GINEBRA, F. C. M. DRIESSENS and J. A. PLANELL, Biomaterials 25(17) (2004) 3453
J. OUYANG, S. DENG and J. ZHOUNG, J. Cryst. Growth 270 (2004) 646
C. C. CHEN and A. L. BOSKEY, Calcif. Tissue Int. 37(4) (1985) 395
T. KOKUBO H. M. KIM and M. KAWASHITA, Biomaterials 24(13) (2003) 2161
D. DELANEY and B. CONSTANTZ. pat (WO2004110316. (2004–12–23)
A.L. OLIVEIRA, P. B. MALAFAYA and R. L. Reis, Biomaterials 24(15) (2003) 2575
A.E. PORTER, N. PATEL, J. N. SKEPPER, S. M. BEST and W. BONFIELD, Biomaterials 24(25) (2003) 4609
G. BEREND and A. J. HEGEDÜS, Thermochim. Acta 11 (1975) 367
C. RUEDA, C. ARIAS, P. GALERA, E. LOPEZ-CABARCOS and A. YAGÜE, Il Farmaco 56 (2001) 527
M. MASUI, M. SUZUKI, Y. FUJISE and N. KANAYAMA, Biochim. Biophys. Acta 1546(2) (2001) 261
L. M. GROVER, J. C. KNOWLES, G. J. P. FLEMING and J. E. BARRALET, Biomaterials 24(23) (2003) 4133
U. Gbureck, S. Dembski, R. Thull and J. E. Barralet, Biomaterials, 26(17) (2005) 3691
M. BOHNER, F. THEISS, D. APELT, W. HIRSIGER, R. HOURIET, G. RIZZOLI, E. GNOS, C. FREI, J. A. AUER and B. VON RECHENBERG, Biomaterials 24(20) (2003) 3463
M. H. PRADO DA SILVA, J. H. C. LIMA, G. A. SOARES, C. N. ELIAS, M. C. ANDRADE, S. M. BEST and I. R. GIBSON, Surf. Coatings Technol. 137(2–3) (2001) 270
L. TORTET, J. R. GAVARRI, G. NIHOUL and A. J. DIANOUX, Solid State Ionics 97 (1997) 253
Acknowledgments
The authors acknowledge financial support from the Spanish Science and Technology Ministry (MAT2006–13646–C03–01) and Comunidad de Madrid (GR/MAT/0501/2004).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tamimi-Mariño, F., Mastio, J., Rueda, C. et al. Increase of the final setting time of brushite cements by using chondroitin 4-sulfate and silica gel. J Mater Sci: Mater Med 18, 1195–1201 (2007). https://doi.org/10.1007/s10856-007-0139-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10856-007-0139-9