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Stimulus-responsive mesoporous silica particles

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Abstract

The field of stimulus-responsive mesoporous silica nanoparticles has expanded greatly over the last decade. Novel advanced drug delivery systems (DDSs) that are using interesting techniques to achieve stimulus responsiveness were developed, advancing the knowledge in both the pharmaceutical and material science fields. In this review, we focus on the stimulus-responsive mesoporous silica systems with gate-like assemblies on pore openings. These assemblies are sensitive to a particular stimulus and allow precise control over the release of cargo. An overview of a variety of gating assemblies in connection with respective stimuli will provide the reader with an insight in the field with the emphasis on the construction of complete drug carrier systems. Systems are presented based on the structure of the nano-gates on pore openings in combination with the release stimuli. New achievements such as co-delivery of drugs, combining multiple stimuli with AND logic and coupling DDSs with targeting moieties and reporting systems are also highlighted.

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Abbreviations

DDS:

Drug delivery system

MS:

Mesoporous silica

TEOS:

Tetraethoxysilane

NP:

Nanoparticle

CA:

Capping agent

UV:

Ultraviolet

DNA:

Deoxyribonucleic acid

PEG:

Poly(ethylene glycol)

PNIPAm:

Poly(N-isopropylacrylamide)

cAMP:

Cyclic adenosine monophosphate

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Acknowledgements

The authors thank the Slovenian Research Agency for financial support.

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  1. Peter Nadrah

    Present address: Slovenian National Building and Civil Engineering Institute, Dimičeva ul. 12, 1000, Ljubljana, Slovenia

Authors and Affiliations

  1. National Institute of Chemistry, Hajdrihova ul. 19, 1001, Ljubljana, Slovenia

    Peter Nadrah & Miran Gaberšček

  2. Faculty of Pharmacy, University of Ljubljana, Aškerčeva c. 7, 1000, Ljubljana, Slovenia

    Odon Planinšek

  3. Centre of Excellence for Low-Carbon Technologies, Hajdrihova ul. 19, 1001, Ljubljana, Slovenia

    Miran Gaberšček

  4. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva c. 5, 1001, Ljubljana, Slovenia

    Miran Gaberšček

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  1. Peter Nadrah
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Correspondence to Miran Gaberšček.

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Nadrah, P., Planinšek, O. & Gaberšček, M. Stimulus-responsive mesoporous silica particles. J Mater Sci 49, 481–495 (2014). https://doi.org/10.1007/s10853-013-7726-6

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