Skip to main content
SpringerLink
Log in

Clinicopathologic characteristics of choroidal melanoma in a North Indian population: analysis of 10-year data

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

To analyze the clinical and histopathological characteristics of choroidal melanomas undergoing enucleation at a tertiary care center in India and compare with data from other countries. A retrospective review of in-patient hospital records from 2001–2011. Patients undergoing enucleation with a clinical diagnosis of choroidal melanoma. A total of 80 eyes were enucleated for choroidal melanoma. The mean age of patients was 46 ± 13.1 years. Tumors with spindle cell morphology were the most common subtype. Necrotic tumors had a higher incidence of scleral invasion and orbital involvement compared to other cellular subtypes. The mean age at enucleation in Asian Indians is nearly a decade less than most other races. Predominance of spindle cell subtype is in contrast to findings of previous studies and could be partly related to the genetic and molecular expression of the melanocytes undergoing malignant transformation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Dan-Ning Hu, Guo-Pei Yu, McCormick SA et al (2005) Population-based incidence of uveal melanoma in various races and ethnic groups. Am J Ophthalmol 140:612–617

    Google Scholar 

  2. Callender GR, Wilder HC, Ash JE (1942) Five hundred melanomas of the choroid and ciliary body followed five years or longer. Am J Ophthalmol 25:562–567

    Google Scholar 

  3. McLean IW, Foster WD, Zimmerman LE, Gamel JW (1983) Modification of callender’s classification of uveal melanoma at the Armed Forces Institute of Pathology. Am J Ophthalmol 96:502–509

    PubMed  CAS  Google Scholar 

  4. Fuchs E (1882) Das Sarcom des Uvealtractus. Wilhelm Braumuller, Vienna

    Google Scholar 

  5. Knapp H (1869) A treatise on intraocular tumors, from original clinical observations and anatomical observations. Williams and Wood, New York

    Google Scholar 

  6. Jackson E (1907) A manual of the diagnosis and treatment of the diseases of the eye, 2nd edn. Saunders, Philadelphia

    Google Scholar 

  7. Bialasiewicz AA, Ma JX, Schandig U et al (1998) Clinical and histopathological aspects of 113 necrotizing malignant melanomas of the choroid. 1. Clinical and histological features of necrotizing choroidal melanomas. Klin Monbl Augenheilkd 213:262–270

    Article  PubMed  CAS  Google Scholar 

  8. Raivio I (1977) Uveal melanomas in Finland (an epidemiological, clinical, histological, and prognostic study). Acta Ophthalmol Suppl 133:1–64

    PubMed  Google Scholar 

  9. Phillpotts BA, Sanders RJ, Shields JA et al (1995) Uveal melanomas in black patients: a case series and comparative review. J Natl Med Assoc 87:709–714

    PubMed Central  PubMed  CAS  Google Scholar 

  10. Margo CE, McLean IW (1984) Malignant melanoma of the choroid and ciliary body in black patients. Arch Ophthalmol 102:77–79

    Article  PubMed  CAS  Google Scholar 

  11. Bergman L, Seregard S, Nilsson B et al (2002) Incidence of uveal melanoma in Sweden from 1960 to 1980. Invest Ophthalmol Vis Sci 43:2579–2583

    PubMed  Google Scholar 

  12. Gislason I, Magnusson B, Tulinius H (1985) Malignant melanoma of the uvea in Iceland 1955–1979. Acta Ophthalmol (Copenh) 63:389–394

    Article  CAS  Google Scholar 

  13. Kuo PK, Puliafito CA, Wang KM, Liu HS, Wu BF (1982) Uveal melanoma in China. Int J Ophthalmic Clin 22:57–71

    Article  CAS  Google Scholar 

  14. Cress RD, Holly EA (1997) Incidence of cutaneous melanoma among non-Hispanic whites, Hispanics, Asians, and blacks: an analysis of California cancer registry data, 1988–93. Cancer Causes Control 8:246–252

    Article  PubMed  CAS  Google Scholar 

  15. Sakamoto T, Sakamoto M, Yoshikawa H et al (1996) Histological findings and prognosis of uveal malignant melanomas I Japanese patients. Am J Ophthalmol 121:276–283

    PubMed  CAS  Google Scholar 

  16. Biswas J, Kabra S, Krishnakumar S et al (2004) Clinical and Histopathological characteristics of Uveal melanomas in Asian Indians, a study of 103 patients. Indian J Ophthalmol 52:41–44

    PubMed  Google Scholar 

  17. Paul EV, Parnell BL, Fraker M (1962) Prognosis of malignant melanomas of the choroid and ciliary body. Int J Ophthalmic Clin 2:387–402

    Article  Google Scholar 

  18. Margo CE, Mulla Z, Billiris K (1998) Incidence of surgically treated uveal melanoma by race and ethnicity. Ophthalmology 105:1087–1090

    Article  PubMed  CAS  Google Scholar 

  19. Virgili G, Gatta G, Ciccolallo L, EUROCARE Working Group et al (2007) Incidence of uveal melanoma in Europe. Ophthalmology 114:2309–2315

    Article  PubMed  Google Scholar 

  20. [No author listed] (1998) Histopathology characteristics of uveal melanomas in eyes enucleated from the Collaborative Ocular Melanoma Study. COMS report no. 6. Am J Ophthalmol 125:745–66

    Google Scholar 

  21. Frenkel S, Hendler K, Pe’er J (2009) Uveal melanoma in Israel in the last two decades: characterization, treatment and prognosis. Isr Med Assoc J 11:280–285

    PubMed  Google Scholar 

  22. Callender GR (1931) Malignant melanotic tumors of the eye (a study of histologic types in 111 cases). Trans Am Acad Ophthalmol Otolaryngol 36:131–142

    Google Scholar 

  23. Wilder HC, Paul EV (1951) Malignant melanoma of the choroid and ciliary body (a study of 2, 535 cases). Mil Surg 109:370–378

    PubMed  CAS  Google Scholar 

  24. Paul E, Parnell B, Fraker M (1962) Prognosis of malignant melanomas of the choroid and ciliary body. Int Ophthalmol Clin 2:387–402

    Article  Google Scholar 

  25. Flocks M, Gerende JH, Zimmerman LE (1955) The size and shape of malignant melanoma of the choroid and ciliary body in relation to prognosis and histologic characteristics (a statistical study of 210 tumors). Trans Am Acad Ophthalmol Otolaryngol 59:740–756

    PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors declare that they have not received any financial grant for the study and have no conflict of interests to declare.

Author information

Authors and Affiliations

  1. Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, 488, New Delhi, India

    Seema Kashyap, Pradeep Venkatesh, Seema Sen, Dinesh Shrey, Sana Tinwala & Satpal Garg

  2. Department of Ophthalmology, Regional Institute of Ophthalmology, PGIMS Rohtak, Rohtak, Haryana, India

    Sumeet Khanduja

Authors
  1. Seema Kashyap
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pradeep Venkatesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Seema Sen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sumeet Khanduja
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dinesh Shrey
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sana Tinwala
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Satpal Garg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sumeet Khanduja.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kashyap, S., Venkatesh, P., Sen, S. et al. Clinicopathologic characteristics of choroidal melanoma in a North Indian population: analysis of 10-year data. Int Ophthalmol 34, 235–239 (2014). https://doi.org/10.1007/s10792-013-9821-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-013-9821-8

Keywords

Search

Navigation