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Propofol Attenuates Pulmonary Injury Induced by Collapse and Reventilation of Lung in Rabbits

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Abstract

Propofol is an anesthetic drug with antioxidant and anti-inflammatory properties. We previously found that propofol attenuated lipopolysaccharide-induced acute lung injury in rabbits. This study was performed to evaluate the effects of propofol on lung injury caused by collapse and reventilation in rabbits. The wet/dry weight ratio of the lung, lung injury scores, percentage of polymorphonuclear leukocytes, albumin concentration, malondialdehyde, and interleukin-8 levels in bronchoalveolar lavage fluid were significantly increased in both lungs of the reventilation group. The degree of increase in these parameters was more significant in the right (reventilated) than in the left (non-reventilated) lung. Propofol attenuated these changes. These findings suggest that reventilation of a collapsed lung can cause injury in the contralateral non-reventilated lung as well as the reventilated lung. Propofol may provide a beneficial effect on lung injury induced by collapse and reventilation of the lung.

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Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, 501-757, South Korea

    Hong-Beom Bae, Seong-Heon Lee, Seok-Jai Kim, Heong-Seok Kim & Sang-Hyun Kwak

  2. Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Qing-Chun Road 79, Hangzhou, 310003, China

    Mei Li

  3. Department of Anesthesiology, Chonnam National University School of Dentistry, Gwangju, 501-757, South Korea

    Cheol-Won Jeong & Sung-Su Chung

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  1. Hong-Beom Bae
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Correspondence to Sang-Hyun Kwak.

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This study was supported by a grant (CRI 1100662-1) Chonnam National University Hospital Research Institute of Clinical Medicine.

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Bae, HB., Li, M., Lee, SH. et al. Propofol Attenuates Pulmonary Injury Induced by Collapse and Reventilation of Lung in Rabbits. Inflammation 36, 680–688 (2013). https://doi.org/10.1007/s10753-012-9592-9

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