Abstract
Although mammals are notoriously poor at regeneration compared with many lower-order species, the hair follicle, particular to mammals, is capable of regeneration following partial amputation. The detailed internal mechanism of this phenomenon is still unclear. Development and regrowth of the hair follicle depends on dermal-epidermal interaction within the hair follicle. Previous studies have shown that Wnt/β-catenin, Shh, Bmp, PDGF, TGF and Notch signals all take part in the development and growth of the hair follicle, and the Wnt/β-catenin signaling additionally plays an indispensable role in hair follicle morphogenesis and regrowth. In this study, we investigated the localization, as well as, protein levels of Wnt/β-catenin signaling molecules during amputated whisker follicle regeneration.
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Abbreviations
- DP:
-
Dermal papilla
- DS:
-
Dermal sheath
- HS:
-
Hair shaft
- IRS:
-
Inner root sheath
- Mx:
-
Matrix
- ORS:
-
Outer root sheath
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Acknowledgments
This work was supported by grants from the National Science Foundation of China (Nos. 81372084, 81171832) and Guangdong Province Outstanding Young Teacher Training Program (No. Yq2013078) and Guangdong Scientific Research Funding Program (No. 2014A020211024). Dr. Stanley Lin is very appreciated for editing the language for this paper.
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Yan-Ping Yuan and Keng Huang have contributed equally to this work.
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Yuan, YP., Huang, K., Xu, YM. et al. Canonical and non-canonical Wnt signaling control the regeneration of amputated rodent vibrissae follicles. J Mol Hist 47, 1–8 (2016). https://doi.org/10.1007/s10735-015-9648-x
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DOI: https://doi.org/10.1007/s10735-015-9648-x