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Blood Pb Levels in pregnant Nigerian women in Abakaliki, South-Eastern Nigeria

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Abstract

Environmental lead (Pb) exposure and toxicity have been recognised as public health problems of global importance, affecting both the developed and developing nations. In this work, blood Pb of pregnant women that were not exposed to lead by their occupation (n = 349), with mean ± SD age of 27.0 ± 4.8 years and gestational age of 21.8 ± 3.1 weeks at recruitment were determined using atomic absorption spectrophotometer. The results showed that 309 (88.5 %) of the women had a mean ± SD blood Pb of 40.0 ± 16.5 μg/dl, which is higher than the current US Centre for Disease Prevention and Control action limit (>10 μg/dl). The observed high prevalence of elevated blood Pb levels may be related to maternal low socioeconomic status. Health education is, therefore, urgently needed to sensitise the general public and the policy makers of the level of Pb exposure in Abakaliki environment and the inherent health implications. In addition to mandatory environmental lead monitoring, blood Pb screening for would-be mother is recommended, and those whose blood Pb are found elevated should be appropriately treated.

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References

  • Adekunle, I. M., Olorundare, O., & Nwange, C. (2009). Assessments of Pb levels and daily intakes from green leafy vegetables of southwest Nigeria. Nutrition and Food Science, 39(4), 413–422.

    Article  Google Scholar 

  • Adekunle, I. M., Ogundele, J. A., Oguntoye, O., & Akinloye, O. A. (2010). Assessment of blood and urine Pb levels of some pregnant women residing in Lagos, Nigeria. Environmental Monitoring and Assessment, 170, 467–474.

    Article  CAS  Google Scholar 

  • Ademuyiwa, O., Arowolo, T., Ojo, D. A., Odukoya, O., Yusuf, A. A., & Akinhanmi, T. F. (2002). Pb levels in blood and urine of some residents of Abeokuta, Nigeria. Trace Element and Electrolytes, 19(2), 63–69.

    CAS  Google Scholar 

  • Adeniyi, F. A. A., & Anetor, J. I. (1999). Pb-poisoning in two distant States of Nigeria: an indication of the real size of the problem. African Journal Medicine and Medical Science, 28, 107–112.

    CAS  Google Scholar 

  • Bellinger, D. (1994). Teratogen update: Pb. Teratology, 50, 367–73.

    Article  CAS  Google Scholar 

  • Borja-Aburto, V. H., Hertz-Picciotto, I., Lopez, M. R., Farias, P., Rios, C., & Bianco, J. (1999). Blood Pb levels measured prospectively and risk of spontaneous abortion. American Journal of Epidemiology, 150, 590–7.

    Article  CAS  Google Scholar 

  • Bradman, A., Eskenazi, B., Sutton, P., Athanasoulis, M., & Goldman, L. R. (2001). Iron deficiency associated with higher blood lead in children living in contaminated environments. Environmental Health Perspectives, 109, 1079–1084.

    Article  CAS  Google Scholar 

  • DeMichele, S. J. (1984). Nutrition of Pb. Comparative Biochemistry and Physiology, 78, 401–8.

    Article  CAS  Google Scholar 

  • Faikoğlu, R., Savan, K., Utku, C., Takar, N., & Zebitay, A. G. (2006). Significance of maternal plasma Pb level in early pregnancy loss. J Environmental Science and Health A Toxicology Hazard Substance & Environmental Engineering, 41, 501–6.

    Article  Google Scholar 

  • Fakayode, S. O., & Olu-Owolabi, B. I. (2003). Heavy metal contamination of roadside topsoil in Osogbo. Nigeria: its relationship to traffic density and proximity to highways. Environ metal Geology., 44, 150–157.

    CAS  Google Scholar 

  • Falcon, M., Vinas, P., & Luna, A. (2003). Placental Pb and outcome of pregnancy. Toxicology, 185, 59–66.

    Article  CAS  Google Scholar 

  • Farias, P., Borja-Aburto, V. H., Rios, C., Hertz-Picciotto, I., Rojas-Lopez, M., & Chavez-Ayala, R. (1996). Blood Pb levels in pregnant women of high and low socioeconomic status in Mexico City. Environmental Health Perspectives, 104, 1070–4.

    Article  CAS  Google Scholar 

  • Ferguson, J. E. (1986). Pb: petrol Pb in the environment and its contribution to human Pb levels. The Science of the Total Environment, 50, 1–54.

    Article  Google Scholar 

  • Gidlow, D. A. (2004). Pb toxicity. Occupational Medicine (London), 54, 76–81.

    Article  CAS  Google Scholar 

  • Gulson, B. L., Jameson, C. W., Mahaffey, K. R., Mizon, K. J., Korsch, M. J., & Vimpani, G. (1997). Pregnancy increases mobilization of Pb from maternal skeleton. The Journal of Laboratory and Clinical Medicine, 130, 51–62.

    Article  CAS  Google Scholar 

  • Gulson, B. L., Mahaffey, K. R., Jameson, C. W., Mizon, K. J., Korsch, M. J., Cameron, M. A., et al. (1998). Mobilisation of Pb from the skeleton during the postnatal period is larger than during pregnancy. The Journal of Laboratory and Clinical Medicine, 131, 324–9.

    Article  CAS  Google Scholar 

  • Gulson, B. L., Mizon, K. J., Palmer, J. M., Korsch, M. J., Taylor, A. J., & Mahaffey, K. R. (2004). Blood Pb changes during pregnancy and postpartum with calcium supplementation. Environmental Health Perspectives, 112, 1499–507.

    Article  CAS  Google Scholar 

  • Harrison, R. M., & Laxen, D. P. H. (1982). Pb pollution: causes and control. Chapman and Hall, New York Pp, 29, 133–158.

    Google Scholar 

  • Hertz-Picciotto, I., Schramm, M., Watt-Morse, M., Chantala, K., Anderson, J., & Osterloh, J. (2000). Patterns and determinants of blood Pb during pregnancy. American Journal of Epidemiology, 152, 829–37.

    Article  CAS  Google Scholar 

  • Hu, H., Rabinowitz, M., & Smith, D. (1998). Bone Pb as biological marker in epidemiological studies of chronic toxicity: conceptual paradigm. Environmental Health Perspectives, 106, 1–8.

    Article  CAS  Google Scholar 

  • Jacobson, B. E., Lokltch, O., & Qulgley, G. C. (1991). Improve sample preparation for accurate determination of low concentration of Pb in whole blood by graphite furnace analysis. Clinical Chemistry, 37, 515–519.

    CAS  Google Scholar 

  • Jin, C., Li, Y. L., Zou, Y., et al. (2008). Blood lead: its effect on trace element levels and iron structure in haemoglobin. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Material and Atoms, 266, 3607–13.

    Article  CAS  Google Scholar 

  • King, J. (2003). The risk of maternal nutritional depletion and poor outcomes increases in early or closely spaced pregnancies. Journal of Nutrition, 133, 1732S–1736S.

    CAS  Google Scholar 

  • Klitzman, S., Sharma, A., Nicaj, L., Vitkevich, R., & Leighton, J. (2002). Pb poisoning among pregnant women in New York City: risk factors and screening practices. Journal of Urban Health, 79(2), 225.

    Article  Google Scholar 

  • Maduabuchi, J. M. U., Nzegwu, C. N., Adigba, E. O., Aloke, R. U., Ezomike, C. N., Okocha, C. E., et al. (2006). Pb and cadmium exposures from canned and non-canned beverages in Nigeria: a public health concern. The Science of the Total Environment, 366(2–3), 621–626.

    Article  CAS  Google Scholar 

  • McMichael, A. J., Vimpani, G. V., Robertson, E. F., Baghurst, P. A., & Clark, P. D. (1986). The Port-Pirie cohort study: maternal blood Pb and pregnancy outcome. Journal of Epidemiology and Community Health, 40, 18–25.

    Article  CAS  Google Scholar 

  • Miranda, M. L., Edwards, S. E., Swamy, G. K., Paul, C. J., & Neelon, B. (2010). Blood Pb levels among pregnant women: historic versus contemporaneous exposure. International Journal of Environmental Research and Public Health, 7, 1508–1519.

    Article  CAS  Google Scholar 

  • Nash, D., Magder, L., Lustberg, M., Sherwin, R. W., Rubin, R. J., Kaufmann, R. B., et al. (2003). Blood Pb, blood pressure, and hypertension in perimenopausal and postmenopausal women. Journal of the American Medical Association, 289, 1523–1532.

    Article  CAS  Google Scholar 

  • National Research Council. (1993). Measuring Pb exposure in infants, children and other sensitive population. Washington DC: National Academy.

    Google Scholar 

  • Nnorom, I. C., Igwe, J. C., & Oji-Nnorom, C. G. (2005). Trace metal contents of facial (make-up) cosmetics commonly used in Nigeria. Afr J Biotech, 4(10), 1133–1138.

    CAS  Google Scholar 

  • Papanikolaou, N. C., Hatzidaki, E. G., Belivanis, S., Tzanakakis, G. N., & Tsatsakis, A. M. (2005). Pb toxicity update: a brief review. Medical Science Monitoring, 11, RA329–336.

    CAS  Google Scholar 

  • Pirkle, J. L., Brody, D. J., Gunter, E. W., Kramer, R. A., Paschal, D. C., Flegal, K. M., et al. (1994). The decline in blood Pb levels in the United States: the National Health and Nutrition Examination Surveys (NHANES). Journal of the American Medical Association, 272, 284–291.

    Article  CAS  Google Scholar 

  • Rabinowitz, M. (1991). Toxicokinetics of bone Pb. Environmental Health Perspectives, 91, 33–37.

    Article  CAS  Google Scholar 

  • Rahman, A., & Hakeem, A. (2003). Blood Pb levels during pregnancy and pregnancy outcome in Karachi women. The Journal of the Pakistan Medical Association, 53, 529–533.

    CAS  Google Scholar 

  • Rastogi, S., Nandlike, K., & Fenster, W. (2007). Elevated blood Pb levels in pregnant women: identification of a high-risk population and interventions. Journal of Perinatal Medicine, 35(6), 492–6.

    Article  CAS  Google Scholar 

  • Rossi, E. (2008). Low level environmental Pb exposure-a continuing challenge. Clinical Biochemistry Review, 29(2), 63–70.

    Google Scholar 

  • Shannon, M. (2003). Severe Pb poisoning in pregnancy. Ambulatory Paediatrics, 3, 37–39.

    Article  Google Scholar 

  • Silbergeld, E., Schwartz, J., & Mahaffey, K. (1988). Pb and osteoporosis: mobilization of Pb from bone in postmenopausal women. Environmental Research, 47, 79–94.

    Article  CAS  Google Scholar 

  • Smith, D. R., Osterloh, J. D., & Flegal, A. R. (1996). Use of endogenous, stable Pb isotopes to determine release of Pb from the skeleton. Environmental Health Perspectives, 104, 60–66.

    Article  CAS  Google Scholar 

  • Sowers, M., Jannaush, M., Scholl, T., Li, W., Kemp, F. W., & Bogden, J. D. (2002). Blood Pb concentrations and pregnancy outcomes. Archives of Environmental Health, 57, 489–95.

    Article  CAS  Google Scholar 

  • Thomas, V. M., Socolow, R. H., Fanelli, J. J., & Spiro, T. G. (1999). Effects of reducing Pb in gasoline: an analysis of the international experience. Environmental Science and Technology, 33, 3942–3948.

    Article  CAS  Google Scholar 

  • Tong, S., von Schirnding, Y. E., & Prapamontol, T. (2000). Environmental Pb exposure: a public health problem of global dimensions. Bulletin of the World Health Organization, 78, 1068–77.

    CAS  Google Scholar 

  • Ugwuja, E. I., Akubugwo, E. I., Ibiam, U, Obidoa, O. and Ugwu, N. C. (2010). Plasma copper and zinc among pregnant women in Abakaliki, Southeastern Nigeria. The Internet Journal of Nutrition and Wellness. 2010 Volume 10 Number 1.

  • Vigeh, M., Yokoyama, K., Seyedaghamiri, Z., Shinohara, A., Matsukawa, T., Chiba, M., et al. (2011). Blood Pb at current acceptable levels may cause preterm labour. Occupational and Environmental Medicine, 68(3), 231–4.

    Article  CAS  Google Scholar 

  • World Health Organization. (2010). Nigeria: mass Pb poisoning from mining activities-Zamfara State. Geneva: WHO.

    Google Scholar 

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Acknowledgments

The authors acknowledged the staff of the Department of Obstetrics and Gynaecology, Federal Medical Centre, Abakaliki for logistic support.

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Authors and Affiliations

  1. Department of Chemical Pathology, Faculty of Clinical Medicine, Ebonyi State University, P.M.B. 053, Abakaliki, Nigeria

    Emmanuel I. Ugwuja

  2. Department of Biochemistry, Faculty of Biological Sciences, Ebonyi State University, Abakaliki, Nigeria

    Udu A. Ibiam & Kingsley N Agbafor

  3. Department of Obstetrics and Gynaecology, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria

    Boniface N. Ejikeme & Johnson A. Obuna

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  1. Emmanuel I. Ugwuja
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  2. Udu A. Ibiam
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  3. Boniface N. Ejikeme
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  4. Johnson A. Obuna
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  5. Kingsley N Agbafor
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Correspondence to Emmanuel I. Ugwuja.

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Ugwuja, E.I., Ibiam, U.A., Ejikeme, B.N. et al. Blood Pb Levels in pregnant Nigerian women in Abakaliki, South-Eastern Nigeria. Environ Monit Assess 185, 3795–3801 (2013). https://doi.org/10.1007/s10661-012-2828-1

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  • DOI: https://doi.org/10.1007/s10661-012-2828-1

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