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ISCEV standard for clinical visual evoked potentials: (2016 update)

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Abstract

Visual evoked potentials (VEPs) can provide important diagnostic information regarding the functional integrity of the visual system. This document updates the ISCEV standard for clinical VEP testing and supersedes the 2009 standard. The main changes in this revision are the acknowledgment that pattern stimuli can be produced using a variety of technologies with an emphasis on the need for manufacturers to ensure that there is no luminance change during pattern reversal or pattern onset/offset. The document is also edited to bring the VEP standard into closer harmony with other ISCEV standards. The ISCEV standard VEP is based on a subset of stimulus and recording conditions that provide core clinical information and can be performed by most clinical electrophysiology laboratories throughout the world. These are: (1) Pattern-reversal VEPs elicited by checkerboard stimuli with large 1 degree (°) and small 0.25° checks. (2) Pattern onset/offset VEPs elicited by checkerboard stimuli with large 1° and small 0.25° checks. (3) Flash VEPs elicited by a flash (brief luminance increment) which subtends a visual field of at least 20°. The ISCEV standard VEP protocols are defined for a single recording channel with a midline occipital active electrode. These protocols are intended for assessment of the eye and/or optic nerves anterior to the optic chiasm. Extended, multi-channel protocols are required to evaluate postchiasmal lesions.

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Notes

  1. A major determinant of the waveform of a VEP is the temporal frequency of the stimulus. At rapid stimulation rates, the waveform becomes approximately sinusoidal and is termed steady-state VEP. VEPs recorded with stimulation at lower temporal frequencies are termed transient VEPs.

  2. Michelson contrast = {[L max − L min]/[L max + L min]} × 100 %, where L = luminance, max = maximum of the white squares and min = minimum of the black squares.

References

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Acknowledgments

ISCEV’s standardization process requires the active participation of individual ISCEV members who act as consultants to the committee which writes the standard.

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Authors and Affiliations

  1. West Virginia University Eye Institute, P.O. Box 9193, Morgantown, WV, 26506-9193, USA

    J. Vernon Odom

  2. Eye Center, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Michael Bach

  3. Aerpio Therapeutics, Cincinnati, OH, USA

    Mitchell Brigell

  4. Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK

    Graham E. Holder

  5. School of Optometry and Vision Sciences, University of Waterloo, Waterloo, Canada

    Daphne L. McCulloch

  6. Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan

    Atsushi Mizota

  7. Department of Neurosciences, Ophthalmic Clinic, Padova University, Padua, Italy

    Alma Patrizia Tormene

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  1. J. Vernon Odom
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  2. Michael Bach
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  3. Mitchell Brigell
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  4. Graham E. Holder
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  5. Daphne L. McCulloch
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  6. Atsushi Mizota
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  7. Alma Patrizia Tormene
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International Society for Clinical Electrophysiology of Vision

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Correspondence to J. Vernon Odom.

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Odom, J.V., Bach, M., Brigell, M. et al. ISCEV standard for clinical visual evoked potentials: (2016 update). Doc Ophthalmol 133, 1–9 (2016). https://doi.org/10.1007/s10633-016-9553-y

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  • DOI: https://doi.org/10.1007/s10633-016-9553-y

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