Abstract
Single hyperthermia session causes an appreciable decrease in adrenocorticocyte count in the adrenal cortex in mice on day 3 of postthermal restitution. Morphological changes in the adrenals under conditions of developing stress reaction manifested in increased structural and functional heterogeneity of adrenocorticocytes in all cortical layers, exhaustion of lipid incorporations in the zona fasciculata cells, pronounced shrinkage of zona reticularis, developing against the background of hemodynamic disorders. Recovery of the total count of adrenocorticocyte population was associated with the appearance of small accumulations of immature cells in the subcapsular area of zona glomerulosa. Despite the absence of pronounced changes in the architectonics of all adrenocortical zones during postthermal restitution, recovery of zona reticularis was incomplete, which manifested in its shrinkage and persistence of degenerative changes in adrenocorticocytes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
G. G. Avtandilov, Medical Morphometry [in Russian], Moscow (1990).
V. V. Vinogradov, Stress: Morphobiology of the Adrenal Cortex [in Russian], Minsk (1998).
V. G. Kaveshnikov and N. K. Kashirina, Morfologiya, 106, Nos. 1–3, 170–175 (1994).
N. K. Kashirina, Byull. Eksp. Biol. Med., 127, No.4, 468–472 (1999).
O. I. Kirillov, Stress Hypertrophy of the Adrenal [in Russian], Moscow (1994).
O. P. Molodykh, E. L. Lushnikova, E. V. Koldysheva, and I. S. Proskuryakova, Byull. Eksp. Biol. Med., 128, No.7, 109–114 (1999).
O. P. Molodykh, L. M. Nepomnyashchikh, E. L. Lushnikova, and M. G. Klinnikova, Ibid., 130, No.9, 346–350 (2000).
M. K. Pugachev, Arkh. Anat., 72, No.5, 73–76 (1977).
F. F. Sultanov, Essays on the Pathogenesis of Body Hyperthermia [in Russian], Ashkhabad (1970).
C. Delarue, V. Contesse, S. Lenglet, et al., Rev. Endocr. Metab. Disord., 2, 253–267 (2001).
J. P. Henry, Intern. Physiol. Behav., 27, 66 (1992).
A. Pellegrini, M. Grieco, G. Materazzi, et al., Histochem. J., 30, 695–701 (1998).
G. W. Wolkersdorfer and S. R. Bornstein, Biochem. Pharmacol., 56, 163–171 (1998).
W. Zieleniewski and J. Zieleniewski, Peptides, 16, 175–176 (1995).
Author information
Authors and Affiliations
Additional information
__________
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 10, pp. 467–471, October, 2005
Rights and permissions
About this article
Cite this article
Koldysheva, E.V., Lushnikova, E.L., Nepomnyashchikh, L.M. et al. Morphogenesis of Adaptation and Compensatory Reactions in Mouse Adrenals during Restitution after Thermal Exposure. Bull Exp Biol Med 140, 464–467 (2005). https://doi.org/10.1007/s10517-005-0520-y
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0520-y