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When to repair ischemic mitral valve regurgitation? An algorithmic approach

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Summary

Background

Despite huge progress in the surgical management of ischemic mitral regurgitation, there is still controversy regarding the ideal treatment option.

Aims

Our study aimed to define an algorithmic approach in order to select those patients who will benefit the most from concomitant mitral valve procedure.

Methods

Patients with mitral regurgitation (MR) who met the inclusion criteria were included in our study. Patients with structural MR including ruptured chordae or papillary muscle, abnormal leaflet thickening, annular calcification, or other valvular or congenital heart diseases, ventricular aneurysms and those who were candidates for other surgical procedures were excluded. A total of 350 patients (about 12 %) were classified as having ischemic mitral regurgitation (IMR) and were enrolled in our analysis. All the patients underwent coronary artery bypass grafting and by the designed algorithmic approach were also decided to have additive procedures for their concomitant IMR.

Results

Six months survival was 91.5 % among all the patients in this study. During the follow-ups 86.9 % of the patients survived . Overall mortality rate was 13.1 % (n = 46), of which 7.1 % (n = 25) occurred due to cardiac and 6 % (n = 21) as a result of a non-cardiac cause.

Conclusion

Individualising methods to select patients suffering from IMR for concomitant mitral valve procedure and coronary artery bypass grafting (CABG) seems to serves more effectively by reducing unnecessary surgeries and at the same time not missing absolute indications for concomitant valve repairs. Our algorithm showed a promising efficacy to effectively select patients for CABG and concomitant mitral valve procedures.

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References

  1. Filsoufi F, Salzberg S, Adams D. Current management of ischemic mitral regurgitation. Mt Sinai J Med. 2005;72:105–15.

    PubMed  Google Scholar 

  2. Micovic S, Milacic P, Otasevic P, et al. Comparison of valve annuloplasty and replacement for ischemic mitral valve incompetence. Heart Surg Forum. 2008;11:E340–E5.

    Article  PubMed  Google Scholar 

  3. Ellis SG, Whitlow PL, Raymond RE, Schneider JP. Impact of mitral regurgitation on long-term survival after percutaneous coronary intervention. Am J Cardiol. 2002;89(3):315–8.

    Article  PubMed  Google Scholar 

  4. Grigioni F, Enriquez-Sarano M, Zehr KJ, Bailey KR, Tajik AJ. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation. 2001;103(13):1759–64.

    Article  PubMed  CAS  Google Scholar 

  5. Grossi EA, Crooke GA, DiGiorgi PL, Schwartz CF, Jorde U, Applebaum RM, et al. Impact of moderate functional mitral insufficiency in patients undergoing surgical revascularization. Circulation. 2006;114(1 Suppl):I573–6.

    PubMed  Google Scholar 

  6. Hickey MS, Smith LR, Muhlbaier LH, Harrell FE, Jr., Reves JG, Hinohara T, et al. Current prognosis of ischemic mitral regurgitation. Implications for future management. Circulation. 1988;78(3 Pt 2):I51–9.

    Google Scholar 

  7. Tcheng JE, Jackman JD, Jr., Nelson CL, Gardner LH, Smith LR, Rankin JS, et al. Outcome of patients sustaining acute ischemic mitral regurgitation during myocardial infarction. Ann Intern Med. 1992;117(1):18–24.

    Article  PubMed  CAS  Google Scholar 

  8. Borger MA, Alam A, Murphy PM, Doenst T, David TE. Chronic ischemic mitral regurgitation: repair, replace or rethink? Ann Thorac Surg. 2006;81(3):1153–61.

    Google Scholar 

  9. Condado JA, Velez-Gimon M. Catheter-based approach to mitral regurgitation. J Interv Cardiol. 2003;16(6):523–34.

    Article  PubMed  Google Scholar 

  10. Christenson JT, Simonet F, Bloch A, Maurice J, Velebit V, Schmuziger M. Should a mild to moderate ischemic mitral valve regurgitation in patients with poor left ventricular function be repaired or not? J Heart Valve Dis. 1995;4(5):484–8; discussion 8–9.

    Google Scholar 

  11. Duarte IG, Shen Y, MacDonald MJ, Jones EL, Craver JM, Guyton RA. Treatment of moderate mitral regurgitation and coronary disease by coronary bypass alone: late results. Ann Thorac Surg. 1999;68(2):426–30.

    Google Scholar 

  12. Tolis GA, Jr., Korkolis DP, Kopf GS, Elefteriades JA. Revascularization alone (without mitral valve repair) suffices in patients with advanced ischemic cardiomyopathy and mild-to-moderate mitral regurgitation. Ann Thorac Surg. 2002;74(5):1476–80; discussion 80–1.

    Article  PubMed  Google Scholar 

  13. Aklog L, Filsoufi F, Flores KQ, Chen RH, Cohn LH, Nathan NS, et al. Does coronary artery bypass grafting alone correct moderate ischemic mitral regurgitation? Circulation. 2001;104(12 Suppl 1):I68–75.

  14. Srivastava AR, Banerjee A, Jacob S, Dunning J. Should patients undergoing coronary artery bypass grafting with mild to moderate ischaemic mitral regurgitation also undergo mitral valve repair or replacement? Interact Cardiovasc Thorac Surg. 2007;6(4):538–46.

    Google Scholar 

  15. Gillinov AM, Wierup PN, Blackstone EH, Bishay ES, Cosgrove DM, White J, et al. Is repair preferable to replacement for ischemic mitral regurgitation? J Thorac Cardiovasc Surg. 2001;122(6):1125–41.

    Google Scholar 

  16. Al-Radi OO, Austin PC, Tu JV, David TE, Yau TM. Mitral repair versus replacement for ischemic mitral regurgitation. Ann Thorac Surg. 2005;79(4):1260–7; discussion −7.

    Article  PubMed  Google Scholar 

  17. Milano CA, Daneshmand MA, Rankin JS, Honeycutt E, Williams ML, Swaminathan M, et al. Survival prognosis and surgical management of ischemic mitral regurgitation. Ann Thorac Surg. 2008;86(3):735–44.

    Article  PubMed  Google Scholar 

  18. Magne J, Girerd N, Senechal M, Mathieu P, Dagenais F, Dumesnil JG, et al. Mitral repair versus replacement for ischemic mitral regurgitation: comparison of short-term and long-term survival. Circulation. 2009;120(11 Suppl):S104–11.

    Article  PubMed  CAS  Google Scholar 

  19. Bach DS, Deeb GM, Bolling SF. Accuracy of intraoperative transesophageal echocardiography for estimating the severity of functional mitral regurgitation. Am J Cardiol. 1995;76(7):508–12.

    Article  PubMed  CAS  Google Scholar 

  20. Roshanali F, Mandegar MH, Yousefnia MA, Rayatzadeh H, Alaeddini F. A prospective study of predicting factors in ischemic mitral regurgitation recurrence after ring annuloplasty. Ann Thorac Surg. 2007;84(3):745–9.

    Article  PubMed  Google Scholar 

  21. Yousefnia MA, Mandegar MH, Roshanali F, Alaeddini F, Amouzadeh F. Papillary muscle repositioning in mitral valve replacement in patients with left ventricular dysfunction. Ann Thorac Surg. 2007;83(3):958–63.

    Article  PubMed  Google Scholar 

  22. Lehmann KG, Francis CK, Dodge HT. Mitral regurgitation in early myocardial infarction. Incidence, clinical detection, and prognostic implications. TIMI Study Group. Ann Intern Med. 1992;117(1):10–7.

    Article  CAS  Google Scholar 

  23. Lamas GA, Mitchell GF, Flaker GC, Smith SC, Jr., Gersh BJ, Basta L, et al. Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators. Circulation. 1997;96(3):827–33.

    Article  PubMed  CAS  Google Scholar 

  24. Aronson D, Goldsher N, Zukermann R, Kapeliovich M, Lessick J, Mutlak D, et al. Ischemic mitral regurgitation and risk of heart failure after myocardial infarction. Arch Intern Med. 2006;166(21):2362–8.

    Article  PubMed  Google Scholar 

  25. Fattouch K, Guccione F, Sampognaro R, Panzarella G, Corrado E, Navarra E, et al. POINT: Efficacy of adding mitral valve restrictive annuloplasty to coronary artery bypass grafting in patients with moderate ischemic mitral valve regurgitation: a randomized trial. J Thorac Cardiovasc Surg. 2009;138(2):278–85.

    Article  PubMed  Google Scholar 

  26. LaPar DJ, Kron IL. Should all ischemic mitral regurgitation be repaired? When should we replace? Curr Opin Cardiol. 2011;26(2):113–7.

    Google Scholar 

  27. Ghoreishi M, Dawood M, Stauffer CE, Gammie JS. Mitral regurgitation: current trends in diagnosis and management. Hosp Pract (Minneap). 2011;39(1):181–92.

    Google Scholar 

  28. Mandegar MH, Roshanali F, Yousefnia MA, Marzban M. Papillary muscle approximation combined with ventriculoplasty in patients with ischemic cardiomyopathy and functional mitral regurgitation: effects on mitral valve and LV shape. Interact Cardiovasc Thorac Surg. 2006;5(2):81–4.

    Article  PubMed  Google Scholar 

  29. Roshanali F, Mandegar MH, Yousefnia MA, Alaeddini F, Wann S. Low-dose dobutamine stress echocardiography to predict reversibility of mitral regurgitation with CABG. Echocardiography. 2006;23(1):31–7.

    Article  PubMed  Google Scholar 

  30. Rao C, Murphy MO, Saso S, Pandis D, Grapsa J, Nihoyannopoulos P, et al. Mitral valve repair or replacement for ischaemic mitral regurgitation: a systematic review. Heart Lung Circ. 2011;20(9):555–65.

    Article  PubMed  Google Scholar 

  31. Tahta SA, Oury JH, Maxwell JM, Hiro SP, Duran CM. Outcome after mitral valve repair for functional ischemic mitral regurgitation. J Heart Valve Dis. 2002;11(1):11–8; discussion 8–9.

    PubMed  Google Scholar 

  32. Hung J, Papakostas L, Tahta SA, Hardy BG, Bollen BA, Duran CM, et al. Mechanism of recurrent ischemic mitral regurgitation after annuloplasty: continued LV remodeling as a moving target. Circulation. 2004;110(11 Suppl 1):II85–90.

    Google Scholar 

  33. Calafiore AM, Gallina S, Di Mauro M, Gaeta F, Iaco AL, D’Alessandro S, et al. Mitral valve procedure in dilated cardiomyopathy: repair or replacement? Ann Thorac Surg. 2001;71(4):1146–52; discussion 52–3.

    Google Scholar 

  34. Messas E, Pouzet B, Touchot B, Guerrero JL, Vlahakes GJ, Desnos M, et al. Efficacy of chordal cutting to relieve chronic persistent ischemic mitral regurgitation. Circulation. 2003;108 Suppl 1:II111–5.

    PubMed  Google Scholar 

  35. Alfieri O, Maisano F, De Bonis M, Stefano PL, Torracca L, Oppizzi M, et al. The double-orifice technique in mitral valve repair: a simple solution for complex problems. J Thorac Cardiovasc Surg. 2001;122(4):674–81.

    Article  PubMed  CAS  Google Scholar 

  36. Kron IL, Green GR, Cope JT. Surgical relocation of the posterior papillary muscle in chronic ischemic mitral regurgitation. Ann Thorac Surg. 2002;74(2):600–1.

    Article  PubMed  Google Scholar 

  37. Miller DC. Ischemic mitral regurgitation redux–to repair or to replace? J Thorac Cardiovasc Surg. 2001;122(6):1059–62.

    Article  PubMed  CAS  Google Scholar 

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The authors declare that there is no actual or potential conflict of interest in relation to this article.

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Correspondence to S. Shoar MD.

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Roshanali, F., Vedadian, A., Shoar, S. et al. When to repair ischemic mitral valve regurgitation? An algorithmic approach. Eur Surg 45, 98–105 (2013). https://doi.org/10.1007/s10353-013-0197-9

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  • DOI: https://doi.org/10.1007/s10353-013-0197-9

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