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Prognostic significance of syndecan-1 expression in squamous cell carcinoma of the tonsil

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Abstract

Background

Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and to show variable expression in many cancers. The cause of these variations in expression is not known to date. In this study, we compared SDC1 status with clinicopathologic parameters to evaluate the prognostic implications of SDC1 status on squamous cell carcinoma (SCC) of the tonsil.

Methods

In 56 cases of tonsillar SCC, we screened SDC1 expression using immunohistochemistry and analyzed the relationships between SDC1 expression and clinicopathological parameters. To identify the cause of the changes in SDC1 expression seen in tumors, we measured the gene dosage of SDC1 in tumor cells using fluorescent in situ hybridization.

Results

SDC1 expression was found in cancer cells in 36 cases (64.3 %) of tonsillar SCC. It was associated with lymph node metastasis (p = 0.010) and a positive surgical resection margin (p = 0.014). On the other hand, it was not significantly correlated with sex, age, smoking status, degree of differentiation, T stage, or distant metastasis. We could not find any copy-number variation of SDC1 in the cases showing increased SDC1 immunopositivity. In addition, strong SDC1 expression in the tumor cells predicted a shorter overall survival (p = 0.020, log-rank).

Conclusions

We showed that SDC1 expression is associated with N stage and the status of resection margin involvement in SCC of the tonsil. With respect to survival, there were unfavorable outcomes in cases with SDC1 positivity. More studies are needed to better understand the role of SDC1 in the progression and invasiveness of tonsillar SCC.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), as funded by the Ministry of Education, Science and Technology (2009-0087026).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Banpodaero 222 Socho-gu, Seoul, 137-701, Korea

    Sung Hak Lee, Youn Soo Lee & Chang Suk Kang

  2. Department of Pathology, College of Medicine, The Catholic University of Korea, Banpodaero 222 Socho-gu, Seoul, 137-701, Korea

    Eun Ji Choi & Su Young Kim

  3. Department of Otorhinolaryngology, College of Medicine, The Catholic University of Korea, Banpodaero 222 Socho-gu, Seoul, 137-701, Korea

    Min Sik Kim & Jun Wook Park

Authors
  1. Sung Hak Lee
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  2. Eun Ji Choi
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  5. Youn Soo Lee
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Correspondence to Youn Soo Lee or Su Young Kim.

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Lee, S.H., Choi, E.J., Kim, M.S. et al. Prognostic significance of syndecan-1 expression in squamous cell carcinoma of the tonsil. Int J Clin Oncol 19, 247–253 (2014). https://doi.org/10.1007/s10147-013-0552-7

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  • DOI: https://doi.org/10.1007/s10147-013-0552-7

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