Skip to main content

Advertisement

Log in

Myelodysplastic syndrome associated with multiple autoimmune disorders

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

The association between myelodysplastic syndromes (MDS) and autoimmune manifestations is not uncommon. As a rule, autoimmune abnormalities follow the diagnosis of MDS. We describe here a patient with MDS who developed a striking spectrum of diverse autoimmune disorders, including dermatitis, polyarthritis, and vasculitis, which preceded the clinical appearance of MDS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Hofmann WK, Lubbert M, Hoelzer D, Phillip Koeffler H (2004) Myelodysplastic syndromes. Hematol J 5:1–8

    Google Scholar 

  2. Hamblin TJ (1996) Immunological abnormalities in myelodysplastic syndromes. Semin Hematol 33:150–162

    Google Scholar 

  3. Giannouli S, Voulgarelis M, Zintzaras E, Tzioufas AG, Moutsopoulos HM (2004) Autoimmune phenomena in myelodysplastic syndromes: a 4-yr prospective study. Rheumatology (Oxford) 43:626–632

    Google Scholar 

  4. George SW, Newman ED (1992) Seronegative inflammatory arthritis in the myelodysplastic syndromes. Semin Arthritis Rheum 21:345–354

    Google Scholar 

  5. Hubscher O, Vilches A, Solmesky S, Riveros D (1996) Polymyalgia rheumatica in patients with myelodysplastic syndromes. J Rheumatol 23:792–793

    Google Scholar 

  6. Kaufman LD, Bahou WF, Fromowitz FB (1997) Myelodysplasia presenting as monoarthritis. J Rheumatol 24:1446–1447

    Google Scholar 

  7. Castro M, Conn DL, Su WP, Garton JP (1991) Rheumatic manifestations in myelodysplastic syndromes. J Rheumatol 18:721–727

    Google Scholar 

  8. Parker JE, Mufti GJ (2004) The myelodysplastic syndromes: a matter of life or death. Acta Haematol 111:78–99

    Google Scholar 

  9. Xu D, Schultz C, Akker Y, Cannizzaro L, Ramesh KH, Du J, Ratech H (2003) Evidence for expression of early myeloid antigens in mature, non-blast myeloid cells in myelodysplasia. Am J Hematol 74:9–16

    Google Scholar 

  10. Marisavljevic D, Rolovic Z, Sefer D, Basara N, Ilic D, Boskovic D, Colovic M (2002) Biological and clinical significance of clonogenic assays in patients with myelodysplastic syndromes. Med Oncol 19:249–259

    Google Scholar 

  11. Blinder VS, Roboz GJ (2003) Hematopoietic growth factors in myelodysplastic syndromes. Curr Hematol Rep 2:453–458

    Google Scholar 

  12. Funato K, Kuriyama Y, Uchida Y, Suzuki A, Miyazawa K, Ohyashiki K (2001) Myelodysplastic syndrome accompanied by Addison’s disease and multiple autoimmune phenomena: steroid therapy resolved cytopenias and all immune disorders. Intern Med 40:1041–1044

    Google Scholar 

  13. Mok CC, Kwan YK (2003) Rheumatoid-like polyarthritis as a presenting feature of metastatic carcinoma: a case presentation and review of the literature. Clin Rheumatol 22:353–354

    Google Scholar 

  14. Stummvoll GH, Aringer M, Machold KP, Smolen JS, Raderer M (2001) Cancer polyarthritis resembling rheumatoid arthritis as a first sign of hidden neoplasms. Report of two cases and review of the literature. Scand J Rheumatol 30:40–44

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dimitrios Farmakis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Farmakis, D., Polymeropoulos, E., Polonifi, A. et al. Myelodysplastic syndrome associated with multiple autoimmune disorders. Clin Rheumatol 24, 428–430 (2005). https://doi.org/10.1007/s10067-004-1059-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-004-1059-4

Keywords

Navigation