Abstract
The association between myelodysplastic syndromes (MDS) and autoimmune manifestations is not uncommon. As a rule, autoimmune abnormalities follow the diagnosis of MDS. We describe here a patient with MDS who developed a striking spectrum of diverse autoimmune disorders, including dermatitis, polyarthritis, and vasculitis, which preceded the clinical appearance of MDS.
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Hofmann WK, Lubbert M, Hoelzer D, Phillip Koeffler H (2004) Myelodysplastic syndromes. Hematol J 5:1–8
Hamblin TJ (1996) Immunological abnormalities in myelodysplastic syndromes. Semin Hematol 33:150–162
Giannouli S, Voulgarelis M, Zintzaras E, Tzioufas AG, Moutsopoulos HM (2004) Autoimmune phenomena in myelodysplastic syndromes: a 4-yr prospective study. Rheumatology (Oxford) 43:626–632
George SW, Newman ED (1992) Seronegative inflammatory arthritis in the myelodysplastic syndromes. Semin Arthritis Rheum 21:345–354
Hubscher O, Vilches A, Solmesky S, Riveros D (1996) Polymyalgia rheumatica in patients with myelodysplastic syndromes. J Rheumatol 23:792–793
Kaufman LD, Bahou WF, Fromowitz FB (1997) Myelodysplasia presenting as monoarthritis. J Rheumatol 24:1446–1447
Castro M, Conn DL, Su WP, Garton JP (1991) Rheumatic manifestations in myelodysplastic syndromes. J Rheumatol 18:721–727
Parker JE, Mufti GJ (2004) The myelodysplastic syndromes: a matter of life or death. Acta Haematol 111:78–99
Xu D, Schultz C, Akker Y, Cannizzaro L, Ramesh KH, Du J, Ratech H (2003) Evidence for expression of early myeloid antigens in mature, non-blast myeloid cells in myelodysplasia. Am J Hematol 74:9–16
Marisavljevic D, Rolovic Z, Sefer D, Basara N, Ilic D, Boskovic D, Colovic M (2002) Biological and clinical significance of clonogenic assays in patients with myelodysplastic syndromes. Med Oncol 19:249–259
Blinder VS, Roboz GJ (2003) Hematopoietic growth factors in myelodysplastic syndromes. Curr Hematol Rep 2:453–458
Funato K, Kuriyama Y, Uchida Y, Suzuki A, Miyazawa K, Ohyashiki K (2001) Myelodysplastic syndrome accompanied by Addison’s disease and multiple autoimmune phenomena: steroid therapy resolved cytopenias and all immune disorders. Intern Med 40:1041–1044
Mok CC, Kwan YK (2003) Rheumatoid-like polyarthritis as a presenting feature of metastatic carcinoma: a case presentation and review of the literature. Clin Rheumatol 22:353–354
Stummvoll GH, Aringer M, Machold KP, Smolen JS, Raderer M (2001) Cancer polyarthritis resembling rheumatoid arthritis as a first sign of hidden neoplasms. Report of two cases and review of the literature. Scand J Rheumatol 30:40–44
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Farmakis, D., Polymeropoulos, E., Polonifi, A. et al. Myelodysplastic syndrome associated with multiple autoimmune disorders. Clin Rheumatol 24, 428–430 (2005). https://doi.org/10.1007/s10067-004-1059-4
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DOI: https://doi.org/10.1007/s10067-004-1059-4