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Squamous cell carcinoma with rhabdoid features of the gingiva: a case report with unusual histology

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Abstract

Squamous cell carcinoma (SCC) with rhabdoid features (SCCRF) is extremely rare in the oral cavity. We report herein a case of oral SCCRF. The patient was a 69-year-old Japanese woman who had been suffering from a mass in the right lower gingiva. Right hemi-mandibulectomy was performed. The gingival tumor was composed of pleomorphic, non-cohesive ovoid tumor cells with abundant cytoplasm and eccentric nuclei, which were positive for both pan-cytokeratin and vimentin. In another portion, moderately differentiated SCC and carcinoma in situ were also seen. A transition zone existed between the components. Finally, we diagnosed SCCRF. Four months after the operation, multiple bone metastases, lung and skin metastases and marked hypercalcemia were found. SCCRF, therefore, might be more aggressive than the usual type of oral SCC.

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Acknowledgments

The author thanks Mr. Isamu Hayashi, Mr. Yoichi Watanabe, Ms. Sachiyo Oono, Ms. Kaori Nagata, Mr. Hiroshi Tashiro, Mr. Koji Muramatsu, Mr. Masatake Honda, Mr. Masato Abe, Ms. Chiho Tashiro, Mr. Takuya Kawasaki, Mr. Shogo Fujii, and Ms. Kazumi Yamamoto, the staff of the Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan, for excellent technical assistance. He is also grateful to Mr. Daniel Mrozek, Medical English Service, Kyoto, Japan, for his valuable help with the English editing of this manuscript.

The authors received no financial support for this research, authorship, and/or publication of this article.

Informed consent

Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images.

Conflict of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Pathology Division, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan

    Kimihide Kusafuka, Tomoko Miki & Takashi Nakajima

  2. Division of Head and Neck Surgery, Shizuoka Cancer Center, Shizuoka, Japan

    Tetsuro Onitsuka, Toshihito Suda, Tomohito Fuke, Tomoyuki Kamijo & Yoshiyuki Iida

  3. Division of Dentistry and Oral Surgery, Shizuoka Cancer Center, Shizuoka, Japan

    Chika Murai

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  1. Kimihide Kusafuka
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  2. Tetsuro Onitsuka
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Correspondence to Kimihide Kusafuka.

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Kusafuka, K., Onitsuka, T., Miki, T. et al. Squamous cell carcinoma with rhabdoid features of the gingiva: a case report with unusual histology. Med Mol Morphol 47, 240–245 (2014). https://doi.org/10.1007/s00795-013-0066-4

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  • DOI: https://doi.org/10.1007/s00795-013-0066-4

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