Abstract
This minireview is prompted by the recent report of Banas et al. (J Biol Inorg Chem 15:1147–1155, 2010), which purports to show and concludes that zinc levels are increased in prostate cancer. Such a conclusion conflicts with the overwhelming corroborating clinical and experimental evidence that has amassed from numerous reports over the past approximately 60 years; these consistently show that prostate zinc levels are decreased in the development and progression of prostate cancer. We submit that this is an established relationship in prostate cancer that must be considered and described in any studies that purport to identify results that are inconsistent with this established relationship. In support of this relationship, we provide a minireview of the information that has led to the establishment of this relationship. As with most established clinical relationships, exceptions and anomalies often exist. However, these must be described and explained in the context of the established relationship, and not in the context of refutation of the established relationship, at least not until sufficient corroborating evidence overwhelms the existing evidence. This provides a background to address and to critique the report of Banas et al. Of broader and more serious implications are the widespread recalcitrance and/or lack of knowledge within the clinical and biomedical research community for recognition that zinc decrease in prostate cancer is an established relationship. This leads to misinformation and misinterpretations regarding clinical, experimental, and epidemiological issues that do not serve the best interests of the scientific, medical, and public communities.
References
Banas A, Kwiatek WM, Banas K, Gajda M, Pawlicki B, Cichocki T (2010) J Biol Inorg Chem (2010) 15:1147–1155. doi:10.1007/s00775-010-0675-5
Costello LC, Franklin RB (2006) Mol Cancer 5:17. doi: 10.1186/1476-4598-5-17
Costello LC, Franklin RB (2001) Oncology 59:269–282
Franklin RF, Costello LC (2007) Arch Biochem Biophys 463:211–217
Franklin RB, Milon B, Feng P, Costello LC (2005) Front Biosci 10:2230–2239
Costello LC, Feng P, Franklin RB (2005) Mitochondrion 5:143–153
Mawson CA, Fischer MI (1952) Can J Med Sci 30:336–339
Yaman M, Atici D, Bakirdere S, Akdeniz I (2005) J Med Chem 48:630–634
Zaichick VY, Sviridova TV, Zaichick S (1997) Int Urol Nephrol 29:565–574
Kurhanewicz J, Vigneron DB, Hricak H, Narayan P, Carroll P, Nelson SJ (1996) Radiology 198:795–805
Györkey F, Min KW, Huff JA, Györkey P (1967) Cancer Res 27:1348–1353
Franklin RB, Feng P, Milon BC, Desouki MM, Singh KK, Kajdacsy-Balla A, Bagasra O, Costello LC (2005) Mol Cancer. 4:32. doi:10.1186/1476-4598-4-32
Cortesi M, Fridman E, Volkov A, Shilstein SSh, Chechik R, Breskin A, Vartsky D, Kleinman N, Kogan G, Moriel E, Gladysh V, Huszar M, Ramon J, Raviv G (2008) Prostate 68:994–1006
Cortesi M, Chechik R, Breskin A, Vartsky D, Ramon J, Raviv G, Volkov A, Fridman E (2009) Phys Med Biol 54:781–796
Acknowledgments
This review and the studies of L.C.C. and R.B.F. described in this review were supported in part by NIH grants CA71207, CA21097, CA79903, CA93443, and DK42839.
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Costello, L.C., Franklin, R.B. Zinc is decreased in prostate cancer: an established relationship of prostate cancer!. J Biol Inorg Chem 16, 3–8 (2011). https://doi.org/10.1007/s00775-010-0736-9
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DOI: https://doi.org/10.1007/s00775-010-0736-9