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Is lithium able to reverse neurological damage induced by vinca alkaloids?

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Summary.

Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP.

Vinca alkaloids induce peripheral neuropathy and muscle damage. The molecular basis of this neurotoxicity has not been fully explained, but a possible role of neurofibrillary degeneration has been reported. We studied both in animals and in humans, whether Li is able to antagonise vinca alkaloid neurotoxicity.

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Authors and Affiliations

  1. Oncology Department, Haematology Division, University of Pisa, Pisa, Italy, , , , , , IT

    M. Petrini & G. Cervetti

  2. Department of Neuroscience, Section of Farmacology, University of Pisa, Pisa, Italy, , , , , , IT

    F. Vaglini, M. Cavalletti & G. U. Corsini

  3. Department of Neuroscience, Section of Neurology, University of Pisa, Pisa, Italy, , , , , , IT

    F. Sartucci & L. Murri

Authors
  1. M. Petrini
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  2. F. Vaglini
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  3. G. Cervetti
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  4. M. Cavalletti
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  5. F. Sartucci
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  6. L. Murri
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  7. G. U. Corsini
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Received September 18, 1998; accepted February 18, 1999

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Petrini, M., Vaglini, F., Cervetti, G. et al. Is lithium able to reverse neurological damage induced by vinca alkaloids? . J Neural Transm 106, 569–575 (1999). https://doi.org/10.1007/s007020050180

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  • DOI: https://doi.org/10.1007/s007020050180

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