Abstract
A splenic marginal zone lymphoma was diagnosed in a female European harvest mouse (Micromys minutus) that presented clinically with poor body condition and abdominal swelling. On palpation, a mass in the cranial abdomen was identified. The owner elected euthanasia. Necropsy revealed a markedly enlarged spleen, which was uniformly pale red. Histological examination of the spleen revealed monomorphic sheets expanding from the marginal zone composed of large polygonal to oval cells containing abundant finely granular eosinophilic cytoplasm. No abnormalities were noted in any other organs. Immunohistochemical evaluation of the tumor cells demonstrated positive staining for CD45R and IgM and negative staining for CD4, CD8 and IgD. The diagnosis of splenic marginal zone lymphoma was based on the anatomical location, the lack of involvement of other organs and the histological and immunohistochemical findings.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chacon JI, Mollejo M, Munoz E et al (2002) Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients. Blood 100:1648–1654
Fredrickson TN, Harris AW (2000) B–lymphoid tumors. In: Fredrickson TN, Harris AW (eds) Atlas of mouse hematopathology. Harwood Academic, Amsterdam, Netherlands, pp 81–98
Fredrickson TN, Lennert K, Chattopadhyay SK et al (1999). Splenic marginal zone lymphomas of mice. Am J Pathol 154:805–812
Harris S (1970) The secret life of the harvest mouse. Hamlyn, London
Hartley JW, Chattopadhyay SK, Lander MR et al (2000) Accelerated appearance of multiple B cell lymphoma types in NFS/N mice congenic for ecotropic murine leukemia viruses. Lab Invest 80:159–169
Mateo M, Mollejo M, Villuendas R et al (1999) 7q31–32 allelic loss is a frequent finding in splenic marginal zone lymphoma. Am J Pathol 154:1583–1589
Morse HC 3rd, Kearney JF, Isaacson PG et al (2001a) Cells of the marginal zone—origins, function and neoplasia. Leuk Res 25:169–178
Morse HC 3rd, Qi CF, Chattopadhyay SK et al (2001b) Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice. Leuk Res 8:719–733
Morse HC 3rd, Anver MR, Fredrickson TN et al (2002) Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 100:246–258
O’Banion MK, Reichmann ME, Sundberg JP (1988) Cloning and characterization of a papillomavirus associated with papillomas and carcinomas in the European harvest mouse (Micromys minutus). J Virol 62:226–233
Shin MS, Fredrickson TN, Hartley JW et al (2004) High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas. Cancer Res 64:4419–4427
Southern HN (1957) The harvest mouse. In: Worden AN, Alastair G, Lane-Petter W (eds) The UFAW handbook on the care and management of laboratory animals, 2nd edn. The Universities Federation for Animal Welfare, London, pp 288–289
Sundberg JP, O’Banion MK, Shima A et al (1988) Papillomas and carcinomas associated with a papillomavirus in European harvest mice (Micromys minutus). Vet Pathol 25:356–361
Valli VE, Vernau W, De Lomrimer LP et al (2006) Canine indolent nodular lymphoma. Vet Pathol 43:241–256
Ward JM, Tadesse-Heath L, Perkins SN et al (1999) Splenic marginal zone B-cell and thymic T-cell lymphomas in p53-deficient mice. Lab Invest 1:3–14
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Doughty, R.W., Bowman, J. & Lightbody, C. Splenic marginal zone lymphoma in a European harvest mouse (Micromys minutus). Comp Clin Pathol 15, 263–266 (2006). https://doi.org/10.1007/s00580-006-0639-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00580-006-0639-x