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A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis

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Abstract

Thyroid hormones play an important role in the growth of the kidney and maintenance of its functions. Prolonged hypothyroidism is known to be accompanied by changes in renal morphology such as thickening of the glomerular and tubular basement membranes as well as increased mesangial matrix. Increased transcapillary leakage of plasma proteins leading to proteinuria and generalized edema is also a known complication of hypothyroidism. In particular, autoimmune thyroiditis is associated with proteinuria. Most previous reports of autoimmune thyroiditis with nephrotic syndrome have demonstrated mixed pathological morphology marked by predominant membranous glomerulopathy. Here we present a patient whose initial presentation with profound hypothyroidism and autoimmune thyroiditis was dominated by nephrotic syndrome secondary to type 1 membranoproliferative glomerulonephritis (MPGN). The association of MPGN and autoimmune thyroiditis is very rare.

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References

  1. Katz AI, Emmanouel DS, Lindheimer MD (1975) Thyroid hormone and the kidney. Nephron 15:223–249

    Article  CAS  Google Scholar 

  2. Tunbridge WM, Vanderpump MP (2000) Population screening for autoimmune thyroid disease. Endocrinol Metab Clin North Am 29:239–253

    Article  CAS  Google Scholar 

  3. Agras PI, Kinik ST, Cengiz N, Baskin E, Saatci U (2005) Autoimmune thyroiditis with associated proteinuria: Report of two patients. J Pediatr Endocrinol Metab 18:319–322

    Article  Google Scholar 

  4. Suher M, Koc E, Ata N, Ensari C (2005) Relation of thyroid disfunction, thyroid autoantibodies, and renal function. Ren Fail 27:739–742

    Article  CAS  Google Scholar 

  5. Weetman AP, Tomlinson K, Amos N, Lazarus JH, Hall R, McGregor AM (1985) Proteinuria in autoimmune thyroid disease. Acta Endocrinol (Copenh) 109:341–347

    Article  CAS  Google Scholar 

  6. Nishimoto A, Tomiyoshi Y, Sakemi T, Kanegae F, Nakamura M, Ikeda Y, Shimazu K, Yonemitzu N (2000) Simultaneous occurrence of minimal change glomerular disease, sarcoidosis and Hashimoto’s thyroiditis. Am J Nephrol 20:425–428

    Article  CAS  Google Scholar 

  7. Weetman AP, Pinching AJ, Pussel BA, Evans DJ, Sweny P, Rees AJ (1981) Membranous glomerulonephritis and autoimmune thyroid disease. Clin Nephrol 15:50–51

    CAS  PubMed  Google Scholar 

  8. Enriquez R, Sirvent AE, Amoros F, Andrada E, Cabezuelo JB, Reyes A (2002) IgA nephropathy and autoimmune thyroiditis. Clin Nephrol 57:406–407

    CAS  PubMed  Google Scholar 

  9. Grcevska L, Polenakovic M, Petrusevska G (2000) Membranous nephropathy associated with thyroid disorders. Nephron 86:534–535

    Article  CAS  Google Scholar 

  10. Illies F, Wingen AM, Bald M, Hoyer PF (2004) Autoimmune thyroiditis in association with membranous nephropathy. J Pediatr Endocrinol Metab 17:99–104

    Article  Google Scholar 

  11. Jordan SC, Buckingham B, Sakai R, Olson D (1981) Studies of immune-complex glomerulonephritis mediated by human thyroglobulin. N Engl J Med 304:1212–1215

    Article  CAS  Google Scholar 

  12. Valentin M, Bueno B, Gutierrez E, Martinez A, Gonzalez E, Espejo B, Torres A (2004) Membranoproliferative glomerulonephritis associated with autoimmune thyroiditis. Nefrologia 3:43–48

    Google Scholar 

  13. Ploth DW, Fitz A, Schnetzler D, Seidenfeld J, Wilson CB (1978) Thyroglobulin-anti-thyroglobulin immune complex glomerulonephritis complicating radioiodine therapy. Clin Immunol Immunopathol 9:327–334

    Article  CAS  Google Scholar 

  14. Dizdar O, Kahraman S, Genctoy G, Ertoy D, Arici M, Altun B, Yasavul U, Turgan C (2004) Membranoproliferative glomerulonephritis associated with type 1 diabetes mellitus and hashimoto’s thyroiditis. Nephrol Dial Transplant 19:988–999

    Article  Google Scholar 

  15. Mahjoub S, Ben Dhia N, Achour A, Zebidi A, Frih A, Elmay M (1991) Primary hypothyroidism and glomerular involvement. Ann Endocrinol (Paris) 52:289–292

    CAS  Google Scholar 

  16. Jordan SC, Johnston WH, Bergstein JM (1978) Immune complex glomerulonephritis mediated by thyroid antigens. Arch Pathol Lab Med 102:530–533

    CAS  PubMed  Google Scholar 

  17. Sato Y, Sasaki M, Kan R, Osaku A, Koyama S, Shibayama S, Sato M, Narumiya K, Takagi T, Kojima M (1989) Thyroid antigen-mediated glomerulonephritis in graves’ disease. Clin Nephrol 31:49–52

    CAS  PubMed  Google Scholar 

  18. Salomon MI, Di Scala V, Grishman E, Brener J, Churg J (1967) Renal lesions in hypothyroidism: A study based on kidney biopsies. Metabolism 16:846–852

    Article  CAS  Google Scholar 

  19. Montenegro J, Gonzalez O, Saracho R, Aguirre R, Gonzalez O, Martinez I (1996) Changes in renal function in primary hypothyroidism. Am J Kidney Dis 27:195–198

    Article  CAS  Google Scholar 

  20. Mooraki A, Broumand B, Neekdoost F, Amirmokri P, Bastani B (2003) Reversible acute renal failure associated with hypothyroidism: Report of four cases with a brief review of literature. Nephrology (Carlton) 8:57–60

    Article  Google Scholar 

  21. Lafayette RA, Costa ME, King AJ (1994) Increased serum creatinine in the absence of renal failure in profound hypothyroidism. Am J Med 96:298–299

    Article  CAS  Google Scholar 

  22. Singer MA (2001) Of mice and men and elephants: Metabolic rate sets glomerular filtration rate. Am J Kidney Dis 37:164–178

    Article  CAS  Google Scholar 

  23. Ford RV, Owens JC, Curd GW Jr, Moyer JH, Spurr CL (1961) Kidney function in various thyroid states. J Clin Endocrinol Metab 21:548–553

    Article  CAS  Google Scholar 

  24. Villabona C, Sahun M, Roca M, Mora J, Gomez N, Gomez JM, Puchal R, Soler J (1999) Blood volumes and renal function in overt and subclinical primary hypothyroidism. Am J Med Sci 318:277–280

    Article  CAS  Google Scholar 

  25. Derubertis FR Jr, Michelis MF, Bloom ME, Mintz DH, Field JB, Davis BB (1971) Impaired water excretion in myxedema. Am J Med 51:41–53

    Article  Google Scholar 

  26. Shankland SJ (2000) New insights into the pathogenesis of membranous nephropathy. Kidney Int 57:1204–1205

    Article  CAS  Google Scholar 

  27. Kerjaschki D (2000) Megalin/GP330 and pathogenetic concepts of membranous glomerulopathy (MGN). Kidney Blood Press Res 23:163–166

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Mount Sinai School of Medicine, One Gustave Levy Pl, P.O. Box 1664, New York, NY, 10029, USA

    Sevgi Gurkan & M. Jeffrey Saland

  2. Pathology, Mount Sinai School of Medicine, New York City, NY, USA

    Steven Dikman

Authors
  1. Sevgi Gurkan
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  2. Steven Dikman
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  3. M. Jeffrey Saland
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Correspondence to Sevgi Gurkan.

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Gurkan, S., Dikman, S. & Saland, M.J. A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis. Pediatr Nephrol 24, 193–197 (2009). https://doi.org/10.1007/s00467-007-0668-y

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  • DOI: https://doi.org/10.1007/s00467-007-0668-y

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