Abstract
Feingold’s syndrome is a recognised syndrome of organ maldevelopment. Renal abnormalities are not a consistent feature. We report the case of a girl with Feingold’s syndrome who had developed end-stage renal failure by the age of 6 years. We recommend that urinary tract imaging be carried out in all children suspected of having Feingold’s syndrome.
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References
Celli J, van Beusekom E, Hennekam RC, Gallardo ME, Smeets DF, de Cordoba SR, Innis JW, Frydman M, Konig R, Kingston H, Tolmie J, Govaerts LC, van Bokhoven H, Brunner HG (2000) Familial syndromic esophageal atresia maps to 2p23–p24. Am J Hum Genet 66:436–444
van Bokhoven H, Celli J, van Reeuwijk J, Rinne T, Glaudemans B, van Beusekom E, Rieu P, Newbury-Ecob RA, Chiang C, Brunner HG (2005) MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. Nat Genet 37:465–467
Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW (1992) Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev 6:2248–2257
Sawai S, Shimono A, Hanaoka K, Kondoh H (1991) Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes. New Biol 3:861–869
Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF (1992) Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev 6:2235–2247
Knoepfler PS, Cheng PF, Eisenman RN (2002) N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 16:699–712
Celli J, van Bokhoven H, Brunner HG (2003) Feingold syndrome: clinical review and genetic mapping. Am J Hum Genet 122:294–300
Frydman M, Katz M, Cabot SG, Soen G, Kauschansky A, Sirota L (1997) MODED: microcephaly-oculo-digito-esophageal-duodenal syndrome. Am J Med Genet 71:251–257
Piersall LD, Dowton SB, McAlister WH, Waggoner DJ (2000) Vertebral anomalies in a new family with ODED syndrome. Clin Genet 57:444–448
Büttiker V, Wojtulewicz J, Wilson M (2000) Imperforate anus in Feingold syndrome. Am J Med Genet 92:166–169
Acknowledgements
Work in the Department of Human Genetics was carried out with financial support from the “Maag Lever Darm Stichting” (MWO 05-71).
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Aslam, M., van Bokhoven, H. & Taylor, C.M. End-stage renal failure, reflux nephropathy and Feingold’s syndrome. Pediatr Nephrol 23, 159–161 (2008). https://doi.org/10.1007/s00467-007-0602-3
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DOI: https://doi.org/10.1007/s00467-007-0602-3