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Clinical features of psoriatic uveitis in Japanese patients

  • Inflammatory Disorders
  • Published:
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Abstract

Purpose

To investigate the clinical features of psoriatic uveitis in Japanese patients.

Methods

Clinical features of 13 consecutive patients with psoriatic uveitis treated at our facility were retrospectively examined using medical records. In this study, we collected data about psoriasis type, uveitis laterality, onset type, HLA types, visual acuity, ocular inflammation localization, anterior segment findings, funduscopy findings, complications, recurrence, and medical treatments for uveitis and skin diseases.

Results

The cohort comprised ten males and three females (43.6 ± 7.1 years old), and types of psoriasis included psoriasis vulgaris (seven cases), psoriatic arthritis (four cases), pustular psoriasis (three cases) and psoriatic erythroderma (one case). Two cases represented complicated cases of pustular psoriasis and psoriatic arthritis. Seven cases were unilateral, and six cases were bilateral. All cases had acute non-granulomatous anterior uveitis, whereas panuveitis occurred in one case. Furthermore, macular edema and vascular leakage on fluorescein angiography occurred in four cases, and hyperemic disc occurred in two cases. Recurrence occurred in nine cases. In addition to topical corticosteroid treatment, eight cases underwent oral immunosuppressive treatment or biologics. All six cases undergoing HLA typing were HLA-A2 positive.

Conclusions

Cases of psoriatic uveitis in Japan appear to present with acute non-granulomatous uveitis; other symptoms may include macular edema, retinal vasculitis, or hyperemic disc.

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Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Ophthalmology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Rie Tanaka, Kazuyoshi Ohtomo & Toshikatsu Kaburaki

  2. Department of Ophthalmology, Tokyo Metropolitan Police Hospital, 4-22-1, Nakano, Nakano-ku, Tokyo, 164-8541, Japan

    Mitsuko Takamoto

  3. Department of Ophthalmology, Kawakita General Hospital, 1-7-3, Asagaya-kita, Suginami-ku, Tokyo, 166-8588, Japan

    Keiko Komae

  4. Department of Ophthalmology, Japan Community Health care Organization Tokyo Shinjuku Medical Center, 5-1, Tsukudocho, Shinjyuku-ku, Tokyo, 162-8543, Japan

    Yujiro Fujino

Authors
  1. Rie Tanaka
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  2. Mitsuko Takamoto
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  3. Keiko Komae
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  4. Kazuyoshi Ohtomo
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  5. Yujiro Fujino
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  6. Toshikatsu Kaburaki
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Corresponding author

Correspondence to Rie Tanaka.

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Tanaka, R., Takamoto, M., Komae, K. et al. Clinical features of psoriatic uveitis in Japanese patients. Graefes Arch Clin Exp Ophthalmol 253, 1175–1180 (2015). https://doi.org/10.1007/s00417-015-2968-4

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  • DOI: https://doi.org/10.1007/s00417-015-2968-4

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