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Effects of orally administered moxaverine on ocular blood flow in healthy subjects

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Abstract

Background

To investigate the effect of orally administered moxaverine (Kollateral forte®) on ocular blood flow in young healthy subjects.

Methods

Sixteen healthy subjects (eight male/eight female) aged between 20 and 32 years were included in this placebo-controlled, double-masked, two-way crossover study. Volunteers received 900 mg moxaverine–hydrochloride administered orally in three equal doses or placebo identical in appearance on 2 study days. Outcome variables were measured at baseline and 5 h after first drug administration. Laser Doppler flowmetry was used to assess choroidal and optic nerve head blood flow. Blood velocities in the retrobulbar vessels were measured with color Doppler imaging.

Results

Neither moxaverine nor placebo changed mean arterial pressure or intraocular pressure. Neither moxaverine nor placebo had an effect on choroidal (moxaverine: by 9.5 ± 17.2 %, placebo 3.8 ± 18.8 %, p = 0.54 between groups) or optic nerve head blood flow (moxaverine: 4.8 ± 10.4 %, placebo: 1.8 ± 10.9 %, p = 0.52 between groups). Similarly, administration of moxaverine did not change blood flow velocities or calculated resistance index in the retrobulbar vessels compared to placebo.

Conclusion

The data of the present study indicate that orally administered moxaverine does not increase ocular blood flow. This is in contrast to previous findings, where parenteral administration of moxaverine lead to a significant increase in choroidal blood flow and blood flow velocities in the retrobulbar vessels. The reason for these differing results is unclear, but may be related to the low bioavailability after oral administration.

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Acknowledgements

The present study was supported by an unrestricted grant from Ursapharm Arzneimittel GmbH, Saarbruecken, Germany.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Doreen Schmidl, Michael Lasta, Agnes Boltz, Semira Kaya, Stefan Palkovits, Franz Prager, Leopold Schmetterer & Gerhard Garhofer

  2. Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria

    Berthold Pemp & Franz Prager

  3. Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria

    Agnes Boltz & Leopold Schmetterer

Authors
  1. Doreen Schmidl
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  2. Berthold Pemp
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  3. Michael Lasta
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  4. Agnes Boltz
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  5. Semira Kaya
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  6. Stefan Palkovits
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  7. Franz Prager
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  8. Leopold Schmetterer
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  9. Gerhard Garhofer
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Corresponding author

Correspondence to Gerhard Garhofer.

Additional information

The authors have no financial relationship with the organization that sponsored the research.

The authors have full control of all primary data, and they agree to allow Graefe's Archive for Clinical and Experimental Ophthalmology to review their data upon request.

ClinicalTrials.gov ID: NCT01629680

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Schmidl, D., Pemp, B., Lasta, M. et al. Effects of orally administered moxaverine on ocular blood flow in healthy subjects. Graefes Arch Clin Exp Ophthalmol 251, 515–520 (2013). https://doi.org/10.1007/s00417-012-2207-1

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  • DOI: https://doi.org/10.1007/s00417-012-2207-1

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