Abstract
We aim to compare the hyaluronic acid to fat graft myringoplasty (HAFGM) technique to a recently described modified-FGM (M-FGM) in the repair of tympanic membrane perforation (TMP). We also aim to evaluate the hearing level improvement postoperatively. We conducted a prospective study in an adult tertiary care center between 2012 and 2013. Adult patients presenting with simple TMP were operated on randomly using either HAFGM or M-FGM under local anesthesia in outpatients’ settings. Success was considered when complete closure is achieved. Audiometric parameters were evaluated pre and postoperatively. Twenty-four patients were included in the study (HAFGM: 10 patients and M-FGM: 14 patients). Complete closure was achieved in 80 % in HAFGM vs 42.8 % in the M-FGM (p = 0.03). The study was abandoned due to the low success rate in first 14 patients of the M-FGM group. The pure tone audiometry was improved postoperatively in the HAFGM only. The study was aborted because of the unsatisfactory obtained results using the MFGM. It also shows the beneficial effect of hyaluronic acid application to FGM for a successful TMP repair.
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References
Amoils CP, Jackler RK, Lustig LR (1992) Repair of chronic tympanic membrane perforations using epidermal growth factor. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 107(5):669–683
Sckolnick JS, Mantle B, Li J, Chi DH (2008) Pediatric myringoplasty: factors that affect success-a retrospective study. Laryngoscope 118(4):723–729
Saliba I (2008) Hyaluronic acid fat graft myringoplasty: how we do it. Clin Otolaryngol 33(6):610–614
Saliba I, Froehlich P (2011) Hyaluronic acid fat graft myringoplasty: an office-based technique adapted to children. Arch Otolaryngol Head Neck Surg 137(12):1203–1209
Saliba I, Knapik M, Froehlich P, Abela A (2012) Advantages of hyaluronic acid fat graft myringoplasty over fat graft myringoplasty. Arch Otolaryngol Head Neck Surg 138(10):950–955
Saliba I, Woods O (2011) Hyaluronic acid fat graft myringoplasty: a minimally invasive technique. Laryngoscope 121(2):375–380
Laurent TC, Fraser JR (1992) Hyaluronan. FASEB J Off Publ Fed Am Soc Exp Biol 6(7):2397–2404
Koc S, Akyuz S, Gurbuzler L, Aksakal C (2013) Fat graft myringoplasty with the newly developed surgical technique for chronic tympanic membrane perforation. Eur Arch Otorhinolaryngol 270(5):1629–1633
Ringenberg JC (1962) Fat graft tympanoplasty. Laryngoscope 72:188–192
Ailhaud G, Grimaldi P, Négrel R (1992) Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 12:207–233
Crandall DL, Hausman GJ, Kral JG (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4(2):211–232
Silverman KJ, Lund DP, Zetter BR, Lainey LL, Shahood JA, Freiman DG et al (1988) Angiogenic activity of adipose tissue. Biochem Biophys Res Commun 153(1):347–352
Chauvin K, Bratton C, Parkins C (1999) Healing large tympanic membrane perforations using hyaluronic acid, basic fibroblast growth factor, and epidermal growth factor. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 121(1):43–47
Güneri EA, Tekin S, Yilmaz O, Ozkara E, Erdağ TK, Ikiz AO et al (2003) The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation. Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 24(3):371–376
McCarty MF (1996) Glucosamine for wound healing. Med Hypotheses 47(4):273–275
Laurent C, Hellström S (1997) Extracellular matrix components reflect the dynamics of a healing tympanic membrane perforation—a histochemical study. Int J Biochem Cell Biol 29(1):221–229
Saliba I, Alzahrani M, Zhu T, Sylvain C (2013) Growth factor expression in hyaluronic acid fat graft myringoplasty. Laryngoscope. doi:10.1002/lary.24468
Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M et al (2010) Basic fibroblast growth factor combined with atelocollagen for closing chronic tympanic membrane perforations in 87 patients. Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 31(1):118–121
Bates DO, Jones ROP (2003) The role of vascular endothelial growth factor in wound healing. Int J Low Extrem Wounds 2(2):107–120
Rapala K (1996) The effect of tumor necrosis factor-alpha on wound healing. An experimental study. Ann Chir Gynaecol Suppl 211:1–53
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Alzahrani, M., Saliba, I. Hyaluronic acid fat graft myringoplasty vs fat patch fat graft myringoplasty. Eur Arch Otorhinolaryngol 272, 1873–1877 (2015). https://doi.org/10.1007/s00405-014-2982-x
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DOI: https://doi.org/10.1007/s00405-014-2982-x