Skip to main content
Log in

Zollinger Ellison syndrome, treated with lansoprazole, during pregnancy

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Zollinger Ellison syndrome (ZES), an ulcerative disease of the upper gastrointestinal tract that involves the production of high levels of gastrin and gastric acid, is a rare, symptomatic, endocrine neoplastic disease.

Case

We report a rare case of gastrinoma that was first diagnosed during pregnancy in which the primary tumor was located in the liver. The ZES was well controlled with Zoton (Lansoprazole) following surgery. The patient had an uneventful pregnancy and delivery without significant complications.

Conclusions

The present case suggests that treatment with Zoton for ZES during pregnancy is safe and effective.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Jensen RT, Gardner JD (1993) Gastrinoma. In: Goi VLW, DiMango EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds) The pancreas: biology, pathophysiology and disease. Raven, New York, pp 931–978

    Google Scholar 

  2. Ellison EH, Wilson SD (1964) The Zollinger–Ellison syndrome: re-appraisal and evaluation of 260 registered cases. Ann Surg 160:512–530

    Article  PubMed  CAS  Google Scholar 

  3. Weber HC, Venzon DJ, Lin JT et al (1995) Determinants of metastatic rate and survival in patients with Zollinger–Ellison syndrome: a prospective long-term study. Gastroenterology 108:1637–1649

    Article  PubMed  CAS  Google Scholar 

  4. McGuigan JE (1998) Zollinger Ellison syndrome and other hypersecretory states. In: Feldman M, Sleineger MH, Scharschmidt BF (eds) Sleineger and Fordtran’s gastrointestinal disease: pathophysiology, diagnosis and management, 6th edn. WB Saunders, Philadelphia, pp 679–695

    Google Scholar 

  5. JE M (1998) Sleineger and Fordtran’s gastrointestinal disease: pathophysiology, diagnosis and management, 6th edn. WB Saunders, Philadelphia

    Google Scholar 

  6. McArthur KE, Richardson CT, Barnett CC, Eshaghi N, Semrud MJ, McClelland RN et al (1996) Laparotomy and proximal gastric vagotomy in Zollinger–Ellison syndrome: results of a 16-year prospective study. Am J Gastroenterol 91:1104–1111

    PubMed  CAS  Google Scholar 

  7. Lamers CBHW, Lind T, Moberg S et al (1984) Omeprazole in Zollinger–Ellison syndrome: effects of single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonist. N Engl J Med 310:758–761

    Article  Google Scholar 

  8. Metz DC, Jensen RT (1995) Advances in gastric antisecretory therapy in Zollinger–Ellison syndrome. In: Mignon M, Jensen RT (eds) Endocrine tumors of the pancreas: recent advances in research and management: frontiers of gastrointestinal research, vol 23. Karger, Basel, pp 240–257

  9. Ezeh UO, Narayan H (1996) Pregnancy does not offer protection against Zollinger–Ellison syndrome. Acta Obstet Gynecol Scand 75(3):302–304

    PubMed  CAS  Google Scholar 

  10. Harper MA, McVeigh JE, Thompson W, Ardill JE, Buchanan KD (1995) Successful pregnancy in association with Zollinger–Ellison syndrome. Am J Obstet Gynecol 173(3 Pt 1):863–864

    Article  PubMed  CAS  Google Scholar 

  11. Stewart CA, Termanini B, Stuliff VR, Corleto VD, Weber HC, Gibril F et al (1997) Management of Zollinger–Ellison syndrome in pregnancy. Am J Obstet Gyncol 176:224–233

    Article  CAS  Google Scholar 

  12. Diav-Citrin O, Arnon J, Shechtman S, Schaefer C, van Tonningen MR, Clementi M, De Santis M, Robert-Gnansia E, Valti E, Malm H, Ornoy A (2005) The safety of proton pump inhibitors in pregnancy: a multicentre prospective controlled study. Aliment Pharmacol Ther 21:269–275

    Article  PubMed  CAS  Google Scholar 

  13. Frick G, Bremme K, Sjogren C, Linden A, Uvnas-Moberg K (1990) Plasma levels of cholecystokinin and gastrin during the menstrual cycle and pregnancy. Acta Obstet Gynecol Scand 69:317–320

    PubMed  CAS  Google Scholar 

  14. Waddell WR, Leonsins AS, Zuidema GD (1959) Gastric secretory and other laboratory studies on two patients with Zollinger–Ellison syndrome. N Eng J Med 260:56–62

    Article  CAS  Google Scholar 

  15. Mentagen CN, Moeller MD, Klotz AP (1974) Protection by pregnancy. Zollinger–Ellison syndrome. J Kans Med Soc 75(2):379

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amit Mayer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mayer, A., Sheiner, E. & Holcberg, G. Zollinger Ellison syndrome, treated with lansoprazole, during pregnancy. Arch Gynecol Obstet 276, 171–173 (2007). https://doi.org/10.1007/s00404-007-0319-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-007-0319-3

Keywords

Navigation