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PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?

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Abstract

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides are rare, but they can be triggered by chemicals, infections and drugs; among them, antithyroid drugs are common. Autoimmune disorders, such as vasculitis, are unusual, but serious complications of antithyroid therapy. Both propylthiouracil (PTU) and methimazole may induce ANCA-associated vasculitis. PTU-induced vasculitides may have different organ involvement patterns. Herein, we report four cases with ANCA-associated vasculitis with different clinical manifestations.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

    N. Şule Yaşar Bilge, Timuçin Kaşifoğlu & Cengiz Korkmaz

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  1. N. Şule Yaşar Bilge
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  2. Timuçin Kaşifoğlu
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  3. Cengiz Korkmaz
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Correspondence to N. Şule Yaşar Bilge.

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Bilge, N.Ş.Y., Kaşifoğlu, T. & Korkmaz, C. PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?. Rheumatol Int 33, 117–120 (2013). https://doi.org/10.1007/s00296-011-2280-5

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  • DOI: https://doi.org/10.1007/s00296-011-2280-5

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