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Transient complete remission of acute lymphoblastic leukemia in relapse after allogeneic bone marrow transplantation induced by donor leukocyte transfusions

  • Case report
  • Published:
Hematology and Cell Therapy

Abstract

We report the case of a young patient with refractory acute lymphoblastic leukemia relapse, after allogeneic bone marrow transplantation, who was treated by donor leukocyte infusions. We observed potent adoptive immunotherapy which produced a cytologic complete remission and total chimeric state. This was of short duration and the patient died of severe graft-versus-host disease. We present a short summary of the literature concerning acute lymphoblastic leukemia and donor leukocyte infusions.

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Authors and Affiliations

  1. Services d’Hématologie et de Biologie Clinique, Clinique Universitaire de Mont-Godinne, B-5530, Mont-Godinne, Belgium

    L. D’Hondt, C. Chatelain, C. Doyen, J. C. Osselaer & A. Bosly

  2. Service d’Hématologie, Cliniques Universitaires Saint-Luc, B-1200, Brussels, Belgium

    A. Ferrant

Authors
  1. L. D’Hondt
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  2. C. Chatelain
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  3. C. Doyen
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  4. J. C. Osselaer
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  5. A. Ferrant
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  6. A. Bosly
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D’Hondt, L., Chatelain, C., Doyen, C. et al. Transient complete remission of acute lymphoblastic leukemia in relapse after allogeneic bone marrow transplantation induced by donor leukocyte transfusions. Hematol Cell Ther 38, 353–354 (1996). https://doi.org/10.1007/s00282-996-0353-9

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  • DOI: https://doi.org/10.1007/s00282-996-0353-9

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