Abstract
Although there are reports of myocardial infarction (MI) in patients with sickle cell diseases, an antemortem diagnosis of acute MI in a patient with compound heterozygous hemoglobin SC disease has not been reported. Herein, we present a patient with hemoglobin SC who suffered an acute MI. She had typical chest pain for myocardial ischemia, associated with ST elevations on the electrocardiogram (EKG) and elevations of cardiac injury markers diagnostic of infarction. The patient was treated with conventional therapies for acute coronary syndrome and also emergent red blood cell exchange. Interestingly, coronary angiography was completely normal in this patient. Potential mechanisms and management for acute MI in patients with sickle cell disease are discussed.
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Barrett O Jr, Saunders DE Jr, McFarland DE, Humphries JO (1984) Myocardial infarction in sickle cell anemia. Am J Hematol 16:139–147
Condon PI, Hayes RJ, Serjeant GR (1980) Retinal and choroidal neovascularization in sickle cell disease. Trans Ophthalmol Soc UK 100:434–439
Harlan JM (2000) Introduction: anti-adhesion therapy in sickle cell disease. Blood 95:365–367
Hebbel RP (1997) Adhesive interactions of sickle erythrocytes with endothelium. J Clin Invest 99:2561–2574
Hossein-Nia M, Nisbet J, Merton GK, Holt DW (1995) Spurious rises of cardiac troponin T. Lancet 346:1558
James TN (2000) Homage to James B. Herrick. A contemporary look at myocardial infarction and at sickle cell disease. Circulation 101:1874–1899
James TN, Riddick L, Massing GK (1994) Sickle cells and sudden death: morphologic abnormalities of the cardiac conduction system. J Lab Clin Med 124:507–520
Longenecker GL, Beyers BJ, Mankad VN (1992) Platelet regulatory prostanoids and platelet release products in sickle cell disease. Am J Hematol 40:12–19
Mansi IA, Rosner F (2002) Myocardial infarction in sickle cell disease. J Natl Med Assoc 94:448–452
Martin CR, Cobb C, Tatter D, Johnson C, Haywood LJ (1983) Acute myocardial infarction in sickle cell anemia. Arch Intern Med 143:830–831
Martin CR, Johnson CS, Cobb C, Tatter D, Haywood LJ (1996) Myocardial infarction in sickle cell disease. J Natl Med Assoc 88:428–432
McCormick WF (1988) Massive nonatherosclerotic myocardial infarction in sickle cell anemia. Am J Forensic Med Pathol 9:151–154
Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO III, Schechter AN, Galdwin MT (2002) Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 8:1383–1389
Rowley P, Enlanda D (1968) Hemoglobin S-C disease presenting as acute cor pulmonale. Am Rev Resp Dis 98:494–500
Saad STO, Arruda VR, Junqueira OOMD, Schelini FA, Coelho OB (1990) Acute myocardial infarction in sickle cell anemia associated with severe hypoxia. Postgrad Med J 66:1068–1070
Schechter AN, Galdwin MT (2003) Hemoglobin and paracrine and endocrine functions of nitric oxide. N Engl J Med 348:1483–1485
Schulman LN, Braunwald E, Rosenthal DS (1997) Hematological–oncological disorders and heart disease. In: Braunwald E (ed) Heart disease: a textbook of cardiovascular medicine, 5th edn. Saunders, Philadelphia, pp 1787–1788
Wun T, Paglieroni T, Rangaswami A, Franklin PH, Welborn J, Cheung A, Tablin F (1998) Platelet activation in patients with sickle cell disease. Br J Hematol 100:741–749
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Wang, H., Laslett, L.J., Richman, C.M. et al. Acute myocardial infarction in hemoglobin SC disease. Ann Hematol 83, 622–624 (2004). https://doi.org/10.1007/s00277-004-0907-2
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DOI: https://doi.org/10.1007/s00277-004-0907-2