Abstract
Purpose
The goal of this study was to analyse a possible association of admission blood glucose with hospital mortality of polytraumatised patients and to develop an outcome prediction model for this patient group.
Methods
The outcome of adult polytraumatised patients admitted to the University Hospital of Berne, Switzerland, between 2002 and 2004 with an ISS ≥ 17, and more than one severely injured organ system was retrospectively analysed.
Results
The inclusion criteria were met by 555 patients, of which 108 (19.5%) died. Hyperglycaemia proved to be an independent predictor for hospital mortality (P < 0.0001), following multiple regression analysis. After inclusion of admission blood glucose, the calculated mortality prediction model performed better than currently described models (P < 0.0001, AUC 0.924).
Conclusion
In this retrospective, single-centre study in polytraumatised patients, admission blood glucose proved to be an independent predictor of hospital mortality following regression analysis controlling for age, gender, injury severity and other laboratory parameters. A reliable admission blood glucose-based mortality prediction model for polytraumatised patients could be established. This observation may be helpful in improving the precision of future outcome prediction models for polytraumatised patients. These observations warrant further prospective evaluation.
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Acknowledgments
The authors thank Prof. Juerg Huesler and Mrs. Eliane Gut (Institute for Mathematical Statistics and Insurance Calculations of the University of Berne, Switzerland), and Dr. Franziska Schöni-Affolter (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) for their support in statistical data analysis.
Conflict of interest statement
This study was solely financially supported by departmental resources. No author has a conflict of interest that relates to the content discussed in this article.
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Kreutziger, J., Wenzel, V., Kurz, A. et al. Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients. Intensive Care Med 35, 1234–1239 (2009). https://doi.org/10.1007/s00134-009-1446-z
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DOI: https://doi.org/10.1007/s00134-009-1446-z